A5036184313- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
- Ovarian cancer diagnosis and treatment
- Religion and Society Interactions
- Opioid Use Disorder Treatment
- Pharmaceutical studies and practices
- Reproductive System and Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Pain Management and Opioid Use
- Metabolism, Diabetes, and Cancer
- Pregnancy and preeclampsia studies
- Pancreatic and Hepatic Oncology Research
- Bone health and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Intensive Care Unit Cognitive Disorders
- Microtubule and mitosis dynamics
- Frailty in Older Adults
- Religion, Ecology, and Ethics
- Hormonal Regulation and Hypertension
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Religion, Society, and Development
- Pharmacy and Medical Practices
- Primary Care and Health Outcomes
Royal Brisbane and Women's Hospital
2015-2025
The University of Queensland
2015-2025
Queensland Health
2022-2023
Women's Hospital
2020
Christ University
2020
Massey University
1974-2017
QIMR Berghofer Medical Research Institute
2015
UNSW Sydney
2001-2014
University of California, Irvine
2013
Princess Alexandra Hospital
2012
The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade. LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation disrupted LIFR mutant animals, which leads poor intrauterine nutrition but allows fetuses continue term. Fetal bone volume reduced greater than three-fold and number osteoclasts increased six-fold, resulting severe osteopenia perinatal bone. Astrocyte numbers are spinal cord...
Hypercalcemia is a common complication of cancer with PTHrP an important mediator. Literature on the underlying causes PTHrP-mediated hypercalcemia, in both malignant and benign conditions, limited to small case series reports.The purpose this study was systematically identify large cases hypercalcemia document differences demographics clinical course between etiologies.This hospital-based, retrospective that identified subjects from 1999 2010 public hospital system Queensland, Australia....
A potential consequence of systemic administration viral vectors is the inadvertent introduction foreign DNA into recipient germ cells. To evaluate safety in vivo recombinant adeno-associated virus (rAAV) mediated gene transfer approaches for hemophilia B, we explored risk germline transmission vector sequences following intramuscular (IM) injection rAAV four species male animals (mouse, rat, rabbit and dog). In biodistribution studies mice rats, there a dose-dependent increase likelihood...
In mammalian oocytes, meiosis arrests at prophase I. Meiotic resumption requires activation of Maturation-Promoting Factor (MPF), comprised a catalytic Cyclin-dependent kinase-1 (Cdk1) and regulatory subunit cyclin B, results in germinal vesicle breakdown (GVBD). Cyclic AMP (cAMP)-mediated Protein Kinase A (PKA) activity sustains arrest by inhibiting Cdk1. However, the link between PKA MPF inhibition remains unclear. Cdc25 phosphatases can activate Cdks removing inhibitory phosphates from...
ABSTRACT The pleiotropic cytokine leukemia inhibitory factor (LIF) is able to promote the growth of mouse primordial germ cells (PGCs) in culture. It unclear whether LIF acts directly on PGCs or indirectly via feeder embryonic somatic cells. To understand role PGC growth, we have carried out molecular and cell culture analyses investigate both ligand its receptor development. stimulate independently presence supporting hypothesis that their growth. We show here transcripts for low-affinity...
Hypercalcemia mediated by 1,25-dihydroxy vitamin D (calcitriol) is uncommon, with evidence on etiology limited to small case series or reports.The objective of the study was systematically identify a large cases calcitriol-mediated hypercalcemia and document presentation, demographics, clinical course across etiologies.The hospital-based, retrospective series, identifying subjects from 1999 through 2009 public hospital system in Queensland, Australia. All patients aged over 18 years were...
The new oral anticoagulants (NOAC) have been extensively studied in the clinical trial setting; however, concerns remain about safety of prescribing elderly and patients with renal impairment.The aim this study was to assess appropriateness NOAC a real-world setting terms patient selection compare demographics those included pivotal trials.One hundred seventy-six from three tertiary university teaching hospitals were identified over 3 months 2014.Median age cohort 74 years (interquartile...
Abstract Background Use of long-acting, reversible contraceptives has increased over the past 20 years, but an understanding how they could influence cancer risk is limited. Methods We conducted a nested case-control study among national cohort Australian women (n = 176 601 diagnosed with between 2004 and 2013; 882 999 matched control individuals) to investigate associations levonorgestrel intrauterine system, etonogestrel implants, depot-medroxyprogesterone acetate compared these results...
Oncostatin M (OSM) is a member of the interleukin-6 family cytokines, and we have reported previously that murine OSM receptor β subunit (OSMR) was expressed in some neurons adult trigeminal dorsal root ganglia (DRGs) perineonatal hypoglossal nucleus. In present study, investigated development OSMR-positive DRGs OSM-deficient mice. situ hybridization revealed began to appear at postnatal day 0 (P0) reached level P14. mice, vanilloid 1 (VR1)- P2X3-positive small-sized were significantly...
Little data is in existence about the most cost-effective primary treatment for Graves' disease. We performed a cost-utility analysis comparing radioactive iodine (RAI), anti-thyroid drugs (ATD) and total thyroidectomy (TT) as first-line therapy disease England Australia.We used Markov model to compare lifetime costs benefits (quality-adjusted life-years (QALYs)). The included efficacy, rates of relapse major complications associated with each treatment, alternative second-line therapies....
The prevalence of gestational diabetes is increasing in Australia.Non-pharmacological intervention with dietary measures and exercise the mainstay therapy most cases, but insulin increasingly necessary to achieve adequate glycaemic control some women.Basal-bolus optimal management strategy, needs be individualised.Although there mounting evidence for efficacy safety metformin, lack long-term follow-up data has prevented it from being recommended by experts field.women need because their...
Abstract Background Rituximab is a monoclonal antibody directed against B cells and increasingly used to treat variety of autoimmune conditions. Most published evidence reporting the successful use rituximab in off‐label indications has empirically high‐dose regimen (either 375 mg/m 2 weekly for 4 weeks, or 1000 mg × 2), which approved course treatment lymphoma rheumatoid arthritis patients. Aims The aims this report are review indications, outcomes adverse events low‐dose (500 twice, given...
Abstract Background and Aim People with new‐onset diabetes mellitus (diabetes) could be a possible target population for pancreatic cancer surveillance. However, distinguishing caused by from type 2 remains challenging. We aimed to develop validate model predict among women diabetes. Methods conducted retrospective cohort study Australian newly diagnosed diabetes, using first prescription of anti‐diabetic medications, sourced administrative data, as surrogate the diagnosis The outcome was...
The COVID-19 pandemic has impacted the management of non-communicable diseases in health systems around world. This study aimed to understand impact on diabetes medicines dispensed Australia. Publicly available data from Australia’s government subsidised program (Pharmaceutical Benefits Scheme), detailing prescriptions by month patients, drug item code and patient category, was obtained January 2016 November 2020. focused used care (Anatomical Therapeutical Chemical level 2 = A10). Number...
Surgery for epithelial ovarian cancer (EOC) may activate stress-inflammatory responses that stimulate tumor growth and increase metastatic growth. Animal in vitro studies have shown inhibition of the catecholamine-induced inflammatory response via beta-adrenergic receptor blockade has antitumor potential EOC. However, observational reported mixed results. We assessed whether beta-blocker (BB) use at time primary surgery was associated with improved survival a large population-based study.
Digital transformation in healthcare improves the safety of health systems. Within our service, a new digital hospital has been established and two wards from neighbouring paper-based transitioned into hospital. This created an opportunity to evaluate impact complete on medication safety. Here we discuss transition voluntarily reported incidents prescribing errors. study utilises interrupted time-series design takes place across as they paper Two data sources are used assess impacts errors:...