A5024288132- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Diabetes Treatment and Management
- Hip and Femur Fractures
- Bariatric Surgery and Outcomes
- Diabetes Management and Research
- Tracheal and airway disorders
- Diverticular Disease and Complications
- Immunodeficiency and Autoimmune Disorders
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
- Pancreatic function and diabetes
- Management of metastatic bone disease
- Mindfulness and Compassion Interventions
- Inhalation and Respiratory Drug Delivery
- Sinusitis and nasal conditions
- Parvovirus B19 Infection Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Bone and Joint Diseases
- Pharmacology and Obesity Treatment
- Social Media in Health Education
- Breast Lesions and Carcinomas
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Nasal Surgery and Airway Studies
VA Tennessee Valley Healthcare System
2024
St. Michael's Hospital
2017-2023
University of Toronto
2023
Food and Nutrition Service
2023
Rush University Medical Center
2023
Yale University
2023
Unity Health Toronto
2022
Fred Hutch Cancer Center
2018
Cancer Research And Biostatistics
2017
Gold Coast Hospital
2015
A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications patients with cystic fibrosis (CF). We measured pH, clinical outcomes, and intestinal transit profiles G551D mutation before after treatment ivacaftor, a CF transmembrane regulator channel (CFTR) potentiator.Observational studies ivacaftor effectiveness were conducted United States Canada. subset subjects ingested wireless motility capsule (n=10) that measures vivo both therapy 1 month...
Hypercalcemia is a common complication of cancer with PTHrP an important mediator. Literature on the underlying causes PTHrP-mediated hypercalcemia, in both malignant and benign conditions, limited to small case series reports.The purpose this study was systematically identify large cases hypercalcemia document differences demographics clinical course between etiologies.This hospital-based, retrospective that identified subjects from 1999 2010 public hospital system Queensland, Australia....
Fifteen patients receiving standard thyroxine replacement therapy (100-200 micrograms daily) for primary hypothyroidism and who had persistently raised free concentrations in their serum were investigated to see whether the dose being given was too high. In addition usual thyroid hormone assays systolic time intervals (which indicate left ventricular contractility) calculated as accurate reflectors of tissue activity. All showed expected increased total concentrations; but mean...
To compare the risk of composite peripheral artery disease (PAD) surgical outcome, including revascularization and amputation procedures, between new users sodium-glucose cotransporter 2 inhibitors (SGLT2is) dipeptidyl peptidase 4 (DPP-4is). This retrospective cohort study U.S. veterans age ≥18 years with diabetes who received care from Veterans Health Administration was performed 1 October 2000 to 31 December 2021. Data were linked Medicare, Medicaid, National Death Index. New use SGLT2i or...
Background: Ivacaftor, the first CFTR modulator drug, leads to significant long-term improvement in lung function and weight gain. The mechanism as well impact of ivacaftor on weight, resting energy expenditure (REE) body composition remains be explored. Methods: This prospective observational study included 18 people with CF (pwCF) (age: median (range) 20 (6-58) years) carrying at least one gating mutation commencing ivacaftor. Assessments composition, REE laboratory investigations were...
ABSTRACT Sixteen patients with senile dementia of the Alzheimer type (SDAT) were compared 11 age‐matched normal subjects respect to their responses thyrotrophin (TSH) and prolactin (PRL) releasing hormone (TRH) challenge. Both groups showed a continuing rise in TSH response at 60 min, no difference was found between groups. A significantly exaggerated PRL 20 min SDAT group. There sexes either or response. These findings, albeit preliminary, may have implications for dopaminergic impairment SDAT.
2038 Background: Most GBM patients relapse within 1 year from diagnosis. Among who progress on standard temozolomide, the optimal therapy is unknown. Resistance to temozolomide partially mediated by DNA repair enzyme, O6-methylguanine-DNA methyltransferase (MGMT). Since MGMT may be depleted prolonged administration, dose-intense schedules overcome resistance in with recurrent GBM. Methods: This a phase 2 single arm study of 75-100 mg/m2/day for 21 days each 28-day cycle. Patients have first...
SWOG S0421 was a large randomized trial comparing docetaxel/prednisone plus placebo (DPP) to atrasentan over 12 cycles for patients with metastatic castration-resistant prostate cancer (mCRPC). The current report presents the PRO results this trial, an important secondary endpoint.The specified two primary endpoints. Palliation of worst pain based on Brief Pain Inventory (BPI), where 2 point difference is defined as clinically meaningful. Improvement functional status Functional Assessment...
Summary Resection of primary tumour is the management choice in patients with ectopic ACTH syndrome. However, tumours may remain unidentified or occult spite extensive efforts at trying to locate them. This can, therefore, pose a major issue as uncontrolled hypercortisolaemia can lead life-threatening infections. We present case 66-year-old gentleman syndrome from an multiple significant complications hypercortisolaemia. Ectopic nature his ACTH-dependent Cushing's was confirmed by...
<p dir="ltr">Objective: To compare the risk of composite peripheral artery disease (PAD) surgical outcome, including revascularization and amputation procedures, between new users sodium-glucose cotransporter-2 inhibitors (SGLT2i) dipeptidyl peptidase-4 (DPP4i). </p><p dir="ltr">Research Design Methods: Retrospective cohort U.S. Veterans > 18 years old with diabetes who received care from Health Administration 10/01/2000 to 12/31/2021. Data were linked Medicare,...
<p dir="ltr">Objective: To compare the risk of composite peripheral artery disease (PAD) surgical outcome, including revascularization and amputation procedures, between new users sodium-glucose cotransporter-2 inhibitors (SGLT2i) dipeptidyl peptidase-4 (DPP4i). </p><p dir="ltr">Research Design Methods: Retrospective cohort U.S. Veterans > 18 years old with diabetes who received care from Health Administration 10/01/2000 to 12/31/2021. Data were linked Medicare,...
Background: Hepatopulmonary syndrome (HPS) is a rare shunting lung disease that caused by liver disease.This complex entails high informational needs for patients and their caregivers.Aims: We sought to analyze existing web resources HPS patients, assess patients' caregivers' needs, develop evaluate tailored web-based educational resource this population.Methods: performed Google TM search HPS.We then administered an electronic assessment survey with [liver disease, intrapulmonary vascular...