A5025690733- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
Translational Therapeutics (United States)
2018-2021
University of Pennsylvania
2018-2021
Target (United States)
2018
Drug delivery by nanocarriers (NCs) has long been stymied dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which adsorbed onto the RBCs transfer from to first downstream of intravascular injection. RH improves for wide range viral vectors. For example, injected intravenously increases liposome organ, lungs, ~40-fold compared with free NCs. Intra-carotid...