A5043949075- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Treatment of Major Depression
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- BRCA gene mutations in cancer
- Ion channel regulation and function
- Cannabis and Cannabinoid Research
- Aortic Disease and Treatment Approaches
- RNA Research and Splicing
- Adenosine and Purinergic Signaling
- Metabolomics and Mass Spectrometry Studies
- Urologic and reproductive health conditions
- Traumatic Brain Injury Research
- Biochemical effects in animals
- RNA modifications and cancer
- Nicotinic Acetylcholine Receptors Study
- Restless Legs Syndrome Research
- Neuroscience of respiration and sleep
- Diabetic Foot Ulcer Assessment and Management
- Surgical Simulation and Training
- Neurological Complications and Syndromes
- Muscle and Compartmental Disorders
Duke University
2023-2025
Indiana University Bloomington
2022
Indiana University
2020
NMDA receptor antagonists have potential for therapeutics in neurological and psychiatric diseases, including neurodegenerative epilepsy, traumatic brain injury, substance abuse disorder (SUD), major depressive (MDD). (S)-ketamine was the first of a novel class antidepressants, rapid-acting to be approved medical use. The stereoisomer, (R)-ketamine (arketamine), is currently under development treatment-resistant depression (TRD). compound has demonstrated efficacy multiple animal models. Two...
Tumor hypoxia drives metabolic shifts, cancer progression, and therapeutic resistance. Challenges in quantifying have hindered the exploitation of this potential "Achilles' heel." While gene expression signatures shown promise as surrogate measures hypoxia, signature usage is heterogeneous debated. Here, we present a systematic pan-cancer evaluation 70 14 summary scores 104 cell lines 5,407 tumor samples using 472 million length-matched random signatures. Signature score choice strongly...
IntroductionPrimary vascular leiomyosarcomas are incredibly rare and have poor prognoses. The purpose of this study was to analyze surgical outcomes patients with primary inferior vena cava (IVC) leiomyosarcoma.MethodsRetrospective review IVC leiomyosarcoma resections performed at a single tertiary care hospital from 2014 2023. A total 13 cases were analyzed, which included 10 females 3 males. Presenting symptoms, tumor characteristics, operative management, post-operative complications,...
As our understanding of neurobiology has progressed, molecular analyses are often performed on small brain areas such as the medial prefrontal cortex (mPFC) or nucleus accumbens. The challenge in this work is to dissect correct area while preserving microenvironment be examined. In paper, we describe a simple, low-cost method using resources readily available most labs. This preserves nucleic acid and proteins by keeping tissue frozen throughout process. Brains cut into 0.5–1.0 mm sections...
Adolescence is an important phase in brain maturation, specifically it a time during which weak synapses are pruned and neural pathways strengthened. also of experimentation with drugs, including cannabis, may have detrimental effects on the developing nervous system. The cannabinoid type 1 receptor (CB
Abstract Genetic testing is becoming rapidly more accessible to the general populous either through or outside healthcare systems. Few large-scale studies have been carried out gauge public opinion in this growing area. Here, we undertook largest cross-sectional study on genetic UK. The primary purpose of identify differences attitudes toward across ethnic groups. A cohort 6500 individuals from a diverse population completed 72-item survey study. Responses between minority and white UK were...
As our understanding of neurobiology has progressed, molecular analyses are often performed on small brain areas such as the medial prefrontal cortex (mPFC) or nucleus accumbens. The challenge in this work is to dissect correct area while preserving microenvironment be examined. In paper, we describe a simple, low-cost method using resources readily available most labs. This preserves nucleic acid and proteins by keeping tissue frozen throughout process. Brains cut into 0.5–1.0 mm sections...
Aortic graft and endograft infections remain a significant source of morbidity mortality after abdominal aortic aneurysm repair. With excision extra-anatomic bypass, an infrarenal stump remains which can have suture line dehiscence catastrophic blowout. Treatment this is extremely challenging, especially for severely co-morbid patients who cannot undergo major surgery, or in with hostile abdomen. We present case study 74-year-old male found to aortoenteric fistula (AEF). This broadens...
Vascular leiomyosarcomas are rare tumors, particularly those arising from the inferior vena cava (IVC). The disease has a poor prognosis with surgical resection being only curative treatment option for patients. purpose of this study was to analyze outcomes patients leiomyosarcoma. There is limited data on management IVC leiomyosarcoma, specifically when ligate or reconstruct IVC; thus, we contributing literature tumor. present retrospective analysis leiomyosarcoma resections performed at...
Traumatic brain injury is a highly prevalent medical condition for which no medications specific the prophylaxis or treatment of as whole exist. The spectrum symptoms includes coma, headache, seizures, cognitive impairment, depression, and anxiety. Although it has been known years that inhibitory neurotransmitter g-amino-butyric acid (GABA) involved in TBI, novel therapeutics based upon this mechanism have introduced into clinical practice. We review neuroanatomical, neurophysiological,...