A5012637586- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Immune Response and Inflammation
- Immune cells in cancer
- Chemokine receptors and signaling
- Reproductive System and Pregnancy
- RNA modifications and cancer
Hull York Medical School
2019-2020
University of York
2019-2020
Abstract Despite extensive mapping of long noncoding RNAs in immune cells, their function vivo remains poorly understood. In this study, we identify over 100 that are differentially expressed within 24 h Th1 cell activation. Among those, show suppression Malat1 is a hallmark CD4+ T activation, but its complete deletion results more potent responses to infection. This because Malat1−/− and Th2 cells express lower levels the immunosuppressive cytokine IL-10. vivo, reduced IL-10 expression...
Beyond sex hormone and chromosome-driven mechanisms, little is known about cell intrinsic mediators of immune sexual dimorphism. We show that Malat1 required for appropriate cytokine expression in female but not male Th2 cells. deficiency impairs vitro differentiation naïve CD4+ T cells from mice, characterised by transcriptome-wide effects suppression expression, particularly IL10. Mechanistically, Malat1-/- mice demonstrate altered early activation kinetics, followed impairment the gene...
Background: The human immune system provides remarkable protection from a plethora of pathogens, but can cause damage when activated for prolonged time (as inpersistent infections) or against self (autoimmunity). Therefore, mechanisms downregulation and control are imperative. There is little data on how the controlled in healthy individuals. We recently described novel population white blood cells that constitutively produce immunomodulatory cytokine interleukin-10 (IL-10). Our objective...