A5021814563- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Historical and modern epidemiology studies
- PARP inhibition in cancer therapy
- RNA Interference and Gene Delivery
- Advanced Electron Microscopy Techniques and Applications
- MicroRNA in disease regulation
- Biochemical and Molecular Research
- Single-cell and spatial transcriptomics
- Cytomegalovirus and herpesvirus research
Kettering University
2022-2024
Memorial Sloan Kettering Cancer Center
2022-2024
Abstract Glioblastoma is a malignant disease with dire prognosis and in urgent need of improved therapeutics. We identify small compound, Gliocidin, that kills glioblastoma cells while sparing replicative mouse embryonic fibroblasts. Gliocidin activity reveals de novo purine synthesis pathway metabolic vulnerability caused by indirect inhibition inosine monophosphate dehydrogenase 2 (IMPDH2). mediated IMPDH2 blockade reduces intracellular guanine nucleotide levels causing imbalance,...
Abstract A number of studies have described an essential role cancer stem cells (CSC) in glioblastoma (GBM) progression and recurrence based on isolation by candidate markers. However, a systematic evaluation the proposed CSC paired human primary recurrent has been lacking whether they represent unified cell type with conserved features over tumor evolution is unresolved. In this study, we used patient derived xenografts (PDX) to investigate status these patients following therapeutics...