A5010499310- Antibiotic Resistance in Bacteria
- RNA and protein synthesis mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Antibiotic Use and Resistance
- Antimicrobial agents and applications
- RNA modifications and cancer
- Tuberculosis Research and Epidemiology
- Genomics and Phylogenetic Studies
- Antimicrobial Resistance in Staphylococcus
University of Leeds
2016-2018
The dissemination of MBLs compromises effective use many β-lactams in the treatment patients with life-threatening bacterial infections. Predicted global increases prevalence MBL-producing carbapenem-resistant Enterobacterales (CRE) are being realized, yielding infections that untreatable existing therapies including newly approved β-lactam/β-lactamase inhibitor combinations. Developing MBL inhibitors (MBLIs) now is essential to address growing threat CRE pose patients.
Bacterial biofilms represent a major impediment to healing in chronic wounds and are largely refractory the antibacterial agents currently used wound management. From repurposing screen of compounds considered safe for topical application humans, we report identification personal care product preservatives bronopol bronidox as broad-spectrum antibiofilm potential candidates reducing biofilm burden wounds.Antibiofilm activity was assessed by viable counting against single-species...
The post-transcriptional modifier tRNA-(N1G37) methyltransferase (TrmD) has been proposed to be essential for growth in many Gram-negative and Gram-positive pathogens, however previously reported inhibitors show only weak antibacterial activity. In this work, optimisation of fragment hits resulted compounds with low nanomolar TrmD inhibition incorporating features designed enhance bacterial permeability covering a range physicochemical space. resulting lack significant activity suggests that...