A5076926419- CRISPR and Genetic Engineering
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Cellular transport and secretion
- Pluripotent Stem Cells Research
- Retinal Development and Disorders
- Autonomous Vehicle Technology and Safety
- Reproductive Health and Contraception
- Molecular Biology Techniques and Applications
- Library Science and Administration
- Renal and Vascular Pathologies
- Ectopic Pregnancy Diagnosis and Management
- Digital and Cyber Forensics
- Clostridium difficile and Clostridium perfringens research
- ICT in Developing Communities
- Renal function and acid-base balance
- Probiotics and Fermented Foods
- Hepatitis B Virus Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Risks and Factors
- Genetics, Aging, and Longevity in Model Organisms
- Web and Library Services
- CAR-T cell therapy research
- Gastrointestinal motility and disorders
- Ethics and Social Impacts of AI
University of California, Los Angeles
2023-2024
Weill Cornell Medicine
2022
Cornell University
2016-2022
Rockefeller University
2016-2019
Government of British Columbia
2019
Tri-Institutional PhD Program in Chemical Biology
2016
University of Tasmania
2015
The complex role of the gut microbiome in pathogenesis gastrointestinal (GI) disorders is an emerging area research, and there considerable interest understanding how diet can alter composition function microbiome. Prebiotics probiotics have been shown to beneficially modulate microbiome, which underlies their potential for benefit GI conditions. Formulating specific recommendations public regarding these dietary supplements has difficult due significant heterogeneity between strains, doses,...
Calcific aortic valve disease (CAVD) is heritable, as revealed by recent GWAS. While polymorphisms linked to increased expression of CACNA1C - encoding the CaV1.2 L-type voltage-gated Ca2+ channel and signaling are associated with CAVD, whether influx through druggable causes CAVD unknown. We confirmed association between in surgically removed valves from patients. extended our studies a transgenic mouse model that mimics within interstitial cells (VICs). In young mice maintained on normal...
Radiotherapy as definitive treatment for invasive cervical cancer during pregnancy causes spontaneous abortion in most cases. Surgical evacuation of the uterus is indicated when does not occur, exposing patients to additional morbidity. Two Latin American women, diagnosed with FIGO stage IB2 at approximately 15 weeks gestation, underwent radiotherapy radiosensitizing chemotherapy. After intrauterine fetal demise was detected, both women induction misoprostol. Results included one complete...
Abstract Objectives Little is known about how physical contact at birth and early caregiving environments influence the colonization of infant gastrointestinal microbiome. We investigated with caregivers within first 2 weeks life relates to composition microbiome in a sample U.S. infants ( n = 60). Methods Skin‐to‐skin were surveyed postpartum. Stool samples collected from weeks, 2, 6, 12 months age underwent 16S rRNA sequencing as proxy for Associations between alpha beta diversity,...
Amid rapid technological change and shifting economic activities, the population of many rural British Columbia communities now requires greater development digital skills. Today's public libraries offer a range services and, therefore, represent significant resource for developing such This study identifies extent to which are promoting technology skills in communities. A qualitative content analysis was conducted on program promotional messaging from library websites Columbia. Results...
ABSTRACTBritish colonists treated Tasmanian Aborigines abominably during the early decades of nineteenth century. Indeed, colonization resulted in near annihilation this ancient and unique people. Their fate, which understandably provokes feelings sympathy anger, has strongly influenced literature on 'Black War'. The are usually portrayed as helpless victims ruthless, even genocidal colonists. This dichotomy, however, is a gross over-simplification. By dehumanizing heartless murderers we...
Our aging society is confronted with a dramatic increase in patients suffering from dementias, such as Alzheimer's disease (AD), for which no mechanism-based cures are available. Animal models, although useful understanding aspects of AD pathology, do not capture key the and have limited use developing treatments. A human model that reproducibly develops disease-relevant molecular pathology cortical neurons would enhance functional studies improve screening drug development. Recent advances...
CRISPR/Cas9 allows sequence-specific gene editing in many organisms and is a promising tool to generate models of human diseases, e.g. pluripotent stem cells (iPSCs). introduces double stranded breaks (DSBs) with high efficiency locus specificity, which are typically repaired by non-homologous end-joining (NHEJ) resulting nonspecific indel mutations, useful for generating knockouts. In rare cases, DSBs can also be homology-directed repair (HDR) using DNA template, such as an introduced...