Yuan Le

ORCID: 0000-0002-0180-3804
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About
Contact & Profiles
Research Areas
  • Drug Transport and Resistance Mechanisms
  • Cancer-related molecular mechanisms research
  • Per- and polyfluoroalkyl substances research
  • Nausea and vomiting management
  • Berberine and alkaloids research
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Dental Anxiety and Anesthesia Techniques
  • Pancreatic function and diabetes
  • Birth, Development, and Health
  • Anesthesia and Pain Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Microbial Metabolism and Applications
  • Thyroid and Parathyroid Surgery
  • Helicobacter pylori-related gastroenterology studies
  • Fibroblast Growth Factor Research
  • Trauma and Emergency Care Studies
  • Genomics, phytochemicals, and oxidative stress
  • Adipose Tissue and Metabolism
  • Abdominal Trauma and Injuries
  • Aldose Reductase and Taurine
  • Gout, Hyperuricemia, Uric Acid
  • Heme Oxygenase-1 and Carbon Monoxide
  • Cancer, Hypoxia, and Metabolism
  • Drug Solubulity and Delivery Systems
  • Traditional Chinese Medicine Studies

Southwest Medical University
2020-2021

St. John's University
2016-2020

Jinzhou Medical University
2020

Nanjing Medical University
2015

Luohe Medical College
2014

Chenzhou First People's Hospital
2005

The incidence rate of thyroid carcinoma ranks ninth among human malignancies, and it accounts for the most frequent malignancy in endocrine-related tumors. This study aimed to investigate role long noncoding RNA (lncRNA) ZFAS1 metastasis papillary (PTC) potential molecular mechanisms. Both MMP3 were highly expressed PTC cell, as measured by q-PCR TCGA database. In addition, induced TPC-1 through inducing epithelial–mesenchymal transition (EMT) process. Besides, knockdown siRNA miR-373-3p...

10.1155/2021/9981683 article EN cc-by International Journal of Endocrinology 2021-06-21

Glucose transporter (Glut) 9 plays an important role in maintaining the homeostasis of uric acid body. Although physiologic functions Glut9 have been well established, regulation expression is less understood. In this study, we showed that mRNA and protein mouse liver kidney are female predominant. Ontogeny studies further revealed female-predominant only occurs adult mice, which primarily attributable to fact sustains females but gradually decreases males after it reaches peak level at day...

10.1124/jpet.116.237040 article EN Journal of Pharmacology and Experimental Therapeutics 2016-11-02

Abstract Epalrestat (EPS), an aldose reductase inhibitor, is widely prescribed to manage diabetic neuropathy. It generally believed that EPS beneficial patients because it can protect endothelial cells, Schwann or other neural cells from oxidative stress. However, several clinical studies revealed therapy led liver dysfunction, which limited its applications. Currently, the underlying mechanism by causes dysfunction unknown. This study aimed investigate responsible for EPS-induced injury. In...

10.1093/toxsci/kfx038 article EN Toxicological Sciences 2017-02-15

Perfluorinated compounds (PFCs), a group of persistent environmental pollutants, are frequently detected in human blood. Epidemiological and animal studies show that there positive associations between higher blood levels PFCs greater risk liver disorders, thyroid reproductive toxicity, immunotoxicity. Nuclear factor erythroid 2‐related (Nrf) 2, transcription can be activated by oxidative stress, electrophiles, accumulated p62 protein after autophagy repression, plays important...

10.1096/fasebj.2019.33.1_supplement.506.12 article EN The FASEB Journal 2019-04-01
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