A5049475465- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Neurobiology and Insect Physiology Research
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- Ergonomics and Musculoskeletal Disorders
- Hippo pathway signaling and YAP/TAZ
- Gene Regulatory Network Analysis
- Genetics and Neurodevelopmental Disorders
- Occupational Health and Safety in Workplaces
- Ergonomics and Human Factors
Linköping University
2007-2023
Neuronal specification is often seen as a multistep process: earlier regulators confer broad neuronal identity and are followed by combinatorial codes specifying properties unique to specific subtypes. However, it still unclear whether early re-deployed in subtype-specific codes, patterning events act restrict the developmental potential of postmitotic cells. Here, we use differential peptidergic fate two lineage-related neurons Drosophila ventral nerve cord show how, feedforward mechanism,...
ABSTRACT The nervous system displays a daunting cellular diversity. Neuronal subtypes differ from each other in several aspects, including their neurotransmitter expression and axon projection. These aspects can converge, but also diverge, such that neurons expressing the same may project axons to different targets. It is not well understood how regulatory programs converge/diverge associate/dissociate cell fate features. Studies of Drosophila Tv1 have identified cascade, ladybird...
ABSTRACT The hypothalamus displays staggering cellular diversity, chiefly established during embryogenesis by the interplay of several signalling pathways and a battery transcription factors. However, contribution epigenetic cues to development remains unclear. We mutated polycomb repressor complex 2 gene Eed in developing mouse hypothalamus, which resulted loss H3K27me3, fundamental mark. This triggered ectopic expression posteriorly expressed regulators (e.g. Hox homeotic genes),...
Abstract Early‐life stress can result in life‐long effects that impact adult health and disease risk, but little is known about how such programming established maintained. Here, we show epigenetic memories be initiated the Drosophila embryo before major wave of zygotic transcription, higher‐order chromatin structures are established. An early short heat shock results elevated levels maternal miRNA reduced a subgroup genes stage 5 embryos. Using Dicer‐1 mutant, stress‐induced decrease one...
During cell cycle progression, the activity of CycE-Cdk2 complex gates S-phase entry. is inhibited by CDK inhibitors (CKIs) Cip/Kip family, which include human p21Cip1 and Drosophila Dacapo (Dap) proteins. Both CycE family proteins are under elaborate control via protein degradation, mediated Cullin-RING ligase (CRL) ubiquitin complexes. The CRL SCFFbxw7/Ago targets phosphorylated CycE, whereas Dap targeted CRL4Cdt2 complex, binding to PIP degron. role CRL-mediated degradation during CNS...
ABSTRACT The hypothalamus displays staggering cellular diversity, chiefly established during embryogenesis by the interplay of several signalling pathways and a battery transcription factors. However, contribution epigenetic cues to development remains unclear. We mutated Polycomb Repressor Complex 2 gene Eed in developing mouse hypothalamus, which resulted loss H3K27me3; fundamental repressor mark. This triggered ectopic expression posteriorly expressed regulators (e.g., Hox homeotic...
SUMMARY Early-life stress can generate persistent life-long effects that impact adult health and disease risk, but little is known of how such programming established maintained. Previous use the Drosophila strain w m4h show an early embryonic heat shock result in stable epigenetic alteration fly. To investigate potential role small non-coding RNA (sncRNA) initiation long-term effects, we here generated a fine timeline sncRNA expression during first 5 stages embryogenesis this strain....