A5089986265- Gastrointestinal motility and disorders
- Ion Transport and Channel Regulation
- Microscopic Colitis
- Magnesium in Health and Disease
- Renal function and acid-base balance
- Digestive system and related health
- Potassium and Related Disorders
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- Gastroesophageal reflux and treatments
- Parathyroid Disorders and Treatments
- Intestinal and Peritoneal Adhesions
- Esophageal and GI Pathology
- Diet and metabolism studies
- Aluminum toxicity and tolerance in plants and animals
- Pharmacological Receptor Mechanisms and Effects
- Cystic Fibrosis Research Advances
- Helicobacter pylori-related gastroenterology studies
- Hydrogen's biological and therapeutic effects
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antibiotics Pharmacokinetics and Efficacy
- Therapeutic Uses of Natural Elements
- Biliary and Gastrointestinal Fistulas
- Electrolyte and hormonal disorders
- Folate and B Vitamins Research
Baylor University Medical Center
2004-2021
University of California, San Diego
2002
Good Samaritan Medical Center
2002
The University of Texas Southwestern Medical Center
1990-1992
United States Department of Veterans Affairs
1984-1992
Southern Methodist University
1989
Wilford Hall Ambulatory Surgical Center
1986
University of California, San Francisco
1984
University of Texas Health Science Center at Dallas
1980
University of Sheffield
1980
The purpose of this study was to measure magnesium absorption over the wide range intakes which intestine may be exposed from food and/or magnesium-containing medications. Net measured in normal subjects after they ingested a standard meal supplemented with 0, 10, 20, 40, and 80 mEq acetate. Although increased each increment intake, fractional fell progressively (from 65% at lowest 11% highest intake) so that as function intake curvilinear. This absorption-intake relationship almost...
Whether ingested calcium is absorbed more efficiently from freely water-soluble salts than poorly soluble unclear. It also unknown whether better dairy products salts. Using a method by which the net absorption of can be accurately measured after single dose, we studied eight healthy fasting subjects they took 500-mg dose each five with various degrees water solubility and milk. The order administration agents given was randomly determined. mean (±SEM) absorption, in decreasing salts, 32±4...
Antacids used to decrease phosphorus absorption in patients with renal failure may be toxic. To find more efficient or less toxic binders, a three-part study was conducted. First, theoretical calculations showed that binding occurs the following order of avidity: Al3+ greater than H+ Ca2+ Mg2+. In presence acid (as stomach), aluminum can therefore bind better calcium magnesium. Second, vitro studies time required reach equilibrium varied from 10 min 3 wk among different compounds, depending...
The purpose of these studies was to gain insight into the pathophysiology pure osmotic diarrhea and caused by carbohydrate malabsorption. Diarrhea induced in normal volunteers ingestion polyethylene glycol (PEG), which is nonabsorbable, not metabolized colonic bacteria, carries no electrical charge. In PEG-induced diarrhea, (a) stool weight directly correlated with total mass PEG ingested; (b) contributed 40-60% osmolality fecal fluid, remainder being other solutes either dietary,...
We studied 16 patients with diabetes and fecal incontinence. The onset of incontinence coincided the chronic diarrhea in most patients. Episodes occurred when stools were frequent loose; however, 24-hour stool weights usually within normal limits. All had evidence autonomic neuropathy, one third steatorrhea. Incontinent diabetics a lower mean basal anal-sphincter pressure than 35 subjects (63 +/- 4 vs. 37 mm Hg; P less 0.001), reflecting abnormal internal-anal-sphincter function. increment...
Phosphorus binders are given to patients with renal failure increase gastrointestinal excretion of phosphorus. To determine the relative importance binding dietary as compared endogenous phosphorus and optimal dose schedule, we gave either 4.4 g calcium acetate (25 mmol calcium) or a placebo six normal subjects on each seven different schedules in randomized sequence. The net balance was determined by one-day lavage technique. After meal containing approximately 12 phosphorus, mean...
It has been known for more than 25 years that certain plant foods, such as kidney beans and wheat, contain a substance inhibits the activity of salivary pancreatic amylase. More recently, this antiamylase purified marketed use in weight control under generic name "starch blockers." Although approach to is highly popular, it never shown whether starch-blocker tablets actually reduce absorption calories from starch. Using oneday calorie-balance technique high-starch (100 g) meal (spaghetti,...
Hyperkalemia in patients with renal failure is frequently treated a cation exchange resin (sodium polystyrene sulfonate, hereafter referred to as resin) combination cathartic, but the effect of such therapy on serum potassium concentration has not been established. This study evaluates four single-dose resin-cathartic regimens and placebo 5 different test days six chronic failure. Dietary intake was controlled. Fecal output were measured for 12 h. Phenolphthalein alone caused an average...
The major purpose of this research was to gain insight into the effect carbohydrate malabsorption on fecal water output. To do we measured daily output total carbohydrate, reducing sugars, and organic acids (a product bacterial fermentation). Normal subjects were studied in their native state when diarrhea induced by mechanisms that did not involve malabsorption. Patients with syndrome also studied. We concluded that: (a) Excretion its breakdown products can be expressed as a single number...
To determine whether the antidiarrheal action of opiate drugs in humans is due to enhanced intestinal absorption rates, as suggested by recent experiments animals, or altered motility, traditionally thought, we studied effect therapeutic doses codeine on experimental diarrhea and rate water electrolytes normal human subjects. Our results show that (30-60 mg i.m.) markedly reduced stool volume during induced rapid intragastric infusion a balanced electrolyte solution. There was, however, no...