Oxidative stress formation is pivotal in the action of environmental agents which trigger activation glial cells and neuroinflammation to stimulate compensatory mechanisms aimed at restoring homeostasis.This study sets demonstrate interplay fluoride (F) aluminium (Al) brain metabolism. Specifically, it reveals how oxidative impacts astrocytes (GFAP), mediates proinflammatory responses (microglia B-cells: CD68 CD 20 respectively) shows pattern lipid peroxidation following (or) treatment...

Fluoride and aluminium have been reported to cause severe alterations in the brain. However, their exact mechanisms of neurotoxic activities remain unknown.This study was designed investigate role fluoride neuronal transport, lysosomal, cell cycle protein acetylcholinesterase activities.Adult Wistar rats were given low high doses fluoride, a combination both with control group receiving distilled water for 30 days. Blood sera brain homogenates quantified alkaline phosphatase (biomarker...

Abstract Aluminum is a potent neurotoxin used in animal models of neurodegenerative diseases like Alzheimer’s disease (AD), which oxidative stress mediates tissue pathogenesis vivo. N-acetyl cysteine (NAC) glutathione precursor with reported antioxidant and neuroprotective potentials. Recent therapy for combating AD known to provide only symptomatic relief thus necessitating the discovery new drugs their mechanism action. This study was aimed demonstrate vivo effect NAC against aluminum (Al...

Anabolic Androgenic steroids (AAS) are abused and reports have been made on their deleterious effects various organs. It is imperative to report the mechanism of inducing oxidative tissue damage even in presence an intracellular antioxidant system by interaction between lipid peroxidation kidney. Twenty (20) adult male Wistar rats used were grouped into: A- Control, BOlive oil vehicle, C- 120 mg/kg AAS orally for three weeks, D- 7 days withdrawal group following mg/kg/ 21days intake. Serum...

Aim of the Study: Currently, reports linked neuropathological changes in Alzheimer’s Disease (AD) to be a risk factor depression. There is need develop natural therapeutics, with strong antioxidant property like Neem leaf, avert AD’s and behavioural using animal model induced by neurotoxin aluminium chloride. This study aimed at ascertaining depressive disorders AD while evaluating mechanism through which averts neurodegeneration fronto-cerebellar cortex possible behaviour. Methodology:...

Objective of the study: Anabolic androgenic steroids (AASs) unlawfully misused for their anabolic effects has deleterious major concerns in public health even presence endogenously produced antioxidants. This study is to evaluate interaction between AAS metabolites and superoxide dismutase (SOD) activity treatment abstinence. Materials Methods: Twenty (20) adult male Wistar used were divided into four (4) groups, A B served as positive negative control given normal saline olive oil...

Objective: To study the effect of aqueous extract dry fruits Piper guineense on male fertility parameters adult Sprague Dawley rats. Materials and Methods: 30 rats weighing between 120g -150g were used. They divided into three (3) groups. The control (group A), Short term treatment Group A (Group B) received 200 mg/kg for 4 weeks (28 days) long C) extracts 8 (56 days). Extract was given via gastric intubation. controls as well treated animals allowed free access to pelleted feed water ad...

The study's goal was to ascertain the contraceptive effects of Aqueous extract Carica papaya on female rats by assessing changes in body weight, estrous cycle, serum progesterone level and cyto-architecture Utero-ovarian tissue.We used twenty (20) healthy young Adult Female Albino rats. study ran for 7 21 days, respectively. Each group has their Experimental (treated 200mg/kg aqueous seed extract) Control (n=5). We determined daily phases frequencies cycles during administration extract....

To investigate the effects of acute and chronic aqueous garlic extract ingestion on testicular cellular integrity serum testosterone levels. Twenty (20) male Sprague-Dawley rats weighing an average 120 g were used. Animals divided into three groups. Group A served as control (10 for 28 56 d respectively), while treatment Groups B C given 200 mg/kg Allium sativum (garlic cloves) respectively. Histological analysis revealed presence all spermatogenic lineages, appearance proliferative...

Studies have raised the possibility that prolonged exposure to fluoride and aluminium in drinking water is capable of causing neurological impairments. Due possible chronic these substances their ability readily interact form a complex which crosses blood-brain barrier, it imperative assess neurotoxic effects. This study describes alterations nervous system as result treatment with 10 mg/kg sodium 200 chloride (AlCl3) for 21 days. Histological sections brain were stained Hematoxylin Eosin...

Traumatic brain injury (TBI) poses a significant risk to neurological function, primarily attributable oxidative stress. Our hypothesis suggests that honey, renowned for its high phenol and flavonoid content, exerts neuroprotective effects by mitigating This study aims assess honey's potential as an innovative therapeutic agent in TBI rat model, focusing on impact behaviour, lipid peroxidation, antioxidant enzyme activity. A total of twenty adult male Wistar rats were randomly divided into...