A5005272789- Neuroendocrine regulation and behavior
- Zebrafish Biomedical Research Applications
- Anesthesia and Neurotoxicity Research
- Neurotransmitter Receptor Influence on Behavior
- Animal Behavior and Reproduction
- Fluoride Effects and Removal
- Evolutionary Psychology and Human Behavior
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Fish Ecology and Management Studies
- Genetic and Environmental Crop Studies
- Bone Metabolism and Diseases
- Death Anxiety and Social Exclusion
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Cell Image Analysis Techniques
- Neurological disorders and treatments
- Biomedical and Engineering Education
- Circadian rhythm and melatonin
- African Botany and Ecology Studies
- Genetics, Bioinformatics, and Biomedical Research
- Parkinson's Disease Mechanisms and Treatments
- Garlic and Onion Studies
- Obsessive-Compulsive Spectrum Disorders
- Neurogenesis and neuroplasticity mechanisms
Instituto Gulbenkian de Ciência
2015-2023
University of Calgary
2022
Bingham University
2013-2015
Olabisi Onabanjo University
2014
Emotional contagion is the most ancestral form of empathy. We tested to what extent proximate mechanisms emotional are evolutionarily conserved by assessing role oxytocin, known regulate empathic behaviors in mammals, social fear zebrafish. Using oxytocin and receptor mutants, we show that both necessary sufficient for observer zebrafish imitate distressed behavior conspecific demonstrators. The brain regions associated with homologous those involved same process rodents (e.g., striatum,...
Oxidative stress formation is pivotal in the action of environmental agents which trigger activation glial cells and neuroinflammation to stimulate compensatory mechanisms aimed at restoring homeostasis.This study sets demonstrate interplay fluoride (F) aluminium (Al) brain metabolism. Specifically, it reveals how oxidative impacts astrocytes (GFAP), mediates proinflammatory responses (microglia B-cells: CD68 CD 20 respectively) shows pattern lipid peroxidation following (or) treatment...
Abstract Neuroscience research in Africa remains sparse. Devising new policies to boost Africa’s neuroscience landscape is imperative, but these must be based on accurate data outputs which largely lacking. Such reflect the heterogeneity of environments across continent’s 54 countries. Here, we analyse publications affiliated with African institutions between 1996 and 2017. Of 12,326 PubMed indexed publications, 5,219 show clear evidence that work was performed led by African-based...
Fluoride and aluminium have been reported to cause severe alterations in the brain. However, their exact mechanisms of neurotoxic activities remain unknown.This study was designed investigate role fluoride neuronal transport, lysosomal, cell cycle protein acetylcholinesterase activities.Adult Wistar rats were given low high doses fluoride, a combination both with control group receiving distilled water for 30 days. Blood sera brain homogenates quantified alkaline phosphatase (biomarker...
Although aggression is more prevalent in males, females also express aggressive behaviors and specific ecological contexts can be than males. The aim of this work to assess sex differences characterize the patterns neuronal activation social-decision making network (SDMN) response intra-sexual both male female zebrafish. Adult fish were exposed social interaction with a same-sex opponent all behavioral displays, latency, time resolution quantified. After conflict resolution, brains sampled...
The alarm substance in fish is a pheromone released by injured individuals after predator attack. When detected other fish, it triggers fear/defensive responses, such as freezing and erratic movement behaviours. Such responses can also help the shoal to modulate their own behaviours: decreasing fear response if conspecifics have not (social buffering) or triggering contagion). Response variation these social phenomena likely depend on sex. Because males higher-risk life-history strategies...
Objective: To study the effect of aqueous extract dry fruits Piper guineense on male fertility parameters adult Sprague Dawley rats. Materials and Methods: 30 rats weighing between 120g -150g were used. They divided into three (3) groups. The control (group A), Short term treatment Group A (Group B) received 200 mg/kg for 4 weeks (28 days) long C) extracts 8 (56 days). Extract was given via gastric intubation. controls as well treated animals allowed free access to pelleted feed water ad...
Background: fourth generation antipsychotics have been implicated in the blockade of calcium signalling through inhibition dopamine receptive sites on dopaminergic D2 Receptor (D3R). As a result abnormal associated with D2R inhibition, changes occur motor and memory neural axis leading to observed behavioural deficits after prolonged haloperidol. Thus, Vitamin D3 receptor (VD3R), controlling striatum can be targeted relief neurological symptoms haloperidol (-D2R) induced PD. Aim: This study...
Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of receptive sites on D2-receptor (D2R). As result D2R inhibition, calcium-linked neural is affected and seen as decline mo-tor-cognitive function after prolonged haloperidol use treatment psychotic disorders. In this study, we have elucidated relationship between haloperidol-induced tardive motor cortex (M1), basal nucleus (CPu), prefrontal (PFC) hippocampus (CA1). Also,...
To investigate the effects of acute and chronic aqueous garlic extract ingestion on testicular cellular integrity serum testosterone levels. Twenty (20) male Sprague-Dawley rats weighing an average 120 g were used. Animals divided into three groups. Group A served as control (10 for 28 56 d respectively), while treatment Groups B C given 200 mg/kg Allium sativum (garlic cloves) respectively. Histological analysis revealed presence all spermatogenic lineages, appearance proliferative...
Abstract Emotional contagion is the most ancestral form of empathy that relies on simple perception-action mechanisms, top which more complex forms empathic behaviors, such as consolation and helping, have evolved. Here we tested to what extent proximate mechanisms emotional are evolutionary conserved by assessing role oxytocin, known regulate behaviors in mammals, social fear zebrafish, represents an divergent line tetrapods, within vertebrates. Using mutants for ligand fish oxytocin...