A5043250449- Cellular transport and secretion
- Pain Mechanisms and Treatments
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Phylogenetic Studies
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- Forensic and Genetic Research
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Retinal Development and Disorders
- EEG and Brain-Computer Interfaces
- Biomedical and Engineering Education
- Microtubule and mitosis dynamics
- Biotechnology and Related Fields
- Heat shock proteins research
- Axon Guidance and Neuronal Signaling
- Protein Structure and Dynamics
- Nicotinic Acetylcholine Receptors Study
- Nerve injury and regeneration
- Lysosomal Storage Disorders Research
- Autism Spectrum Disorder Research
University of Cambridge
2021-2024
UK Dementia Research Institute
2021-2024
University of Verona
2021-2024
University of Oxford
2021-2023
Al-Neelain University
2018-2023
Science Oxford
2023
University of Sussex
2018
Cell functions rely on intracellular transport systems distributing bioactive molecules with high spatiotemporal accuracy. The endoplasmic reticulum (ER) tubular network constitutes a system for delivering luminal solutes, including Ca2+, across the cell periphery. How ER structure enables this nanofluidic is unclear. Here, we show that membrane-localized reticulon 4 (RTN4/Nogo) sufficient to impose neurite outgrowth inhibition in human cortical neurons while acting as an morphoregulator....
Abstract Neuroscience research in Africa remains sparse. Devising new policies to boost Africa’s neuroscience landscape is imperative, but these must be based on accurate data outputs which largely lacking. Such reflect the heterogeneity of environments across continent’s 54 countries. Here, we analyse publications affiliated with African institutions between 1996 and 2017. Of 12,326 PubMed indexed publications, 5,219 show clear evidence that work was performed led by African-based...
Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native conformation, whilst eliminating misfolded, aggregation prone species. underlies pathologies including neurodegeneration. Aggregates' formation antagonised molecular chaperones, with cytoplasmic machinery resolving insoluble protein aggregates. However, it unknown whether an analogous disaggregation system exists in the Endoplasmic Reticulum (ER) where ~30% of proteome synthesised. Here we...
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. PSAM 4 -GlyR modular system based on α7 nicotinic acetylcholine and glycine receptors, which responds inert chemical ligands clinically approved drug varenicline. Here, we demonstrated efficacy this channel silencing both mouse by...
Abstract Introduction Pain in patients with rheumatoid arthritis (RA) is an unmet clinical need. Targeting joint inflammation disease modifying antirheumatic drugs (DMARDs) has not resulted the anticipated reduction pain for many patients. This can partly be explained by concept of central sensitisation whereby spinal and supraspinal pathways have a lower threshold activation leading to increased perception pain. Synovial stromal cells such as fibroblasts are also thought play role through...
Cell and tissue functions rely on an elaborate intracellular transport system responsible for distributing bioactive molecules with high spatiotemporal accuracy. The tubular network of the Endoplasmic Reticulum (ER) constitutes a delivery luminal solutes it stores, including Ca 2+ , across cell periphery. physical nature factors underlying ER's functioning as fluidics are unclear. Using improved ER visualisation methodology combined optogenetic dynamics imaging, we observed that is modulated...
Mitochondria are maternally inherited cell organelles with their own genome, and perform various functions in eukaryotic cells such as energy production cellular homeostasis. Due to inheritance manifold biological roles health disease, mitochondrial genetics serves a dual purpose of tracing the history well disease susceptibility human populations across globe. This work requires comprehensive catalogue commonly observed genetic variations DNAs for all regions throughout world. So far,...
Several challenges contribute to Africa’s trailing position in the global production of knowledge. Decades focused work through international and local programmes have thus far been unable lift continent onto its scientific feet. To learn more about strengths weaknesses neuroscience research carried out on today, that would enable development robust focusing specific needs, a strategy is required extract information contributions African laboratories. Nigeria, most populous nation, among top...
Abstract Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. PSAM 4 -GlyR modular system based on α7 nicotinic acetylcholine and glycine receptors, which responds inert chemical ligands clinically-approved drug, varenicline. Here, we demonstrated efficacy this channel silencing...
Abstract Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native three-dimensional conformation with high fidelity whilst eliminating misfolded, aggregation-prone species. While protein aggregates can contribute pathologies exemplified Alzheimer’s and Parkinson’s diseases, abundance normally minimised molecular chaperones such as HSP70/90, which promote folding drive the recycling of aberrantly folded Cytoplasmic (e.g. HSP70/40) resolve insoluble...
Abstract Introduction Mitochondria are maternally inherited cell organelles with their own genome, and perform various functions in eukaryotic cells such as energy production cellular homeostasis. Due to inheritance manifold biological roles health disease, mitochondrial genetics serves a dual purpose of tracing the history well disease susceptibility human populations across globe. This work requires comprehensive catalogue commonly observed genetic variations DNAs for all regions...