A5088637676- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
Science Oxford
2023
University of Oxford
2023
Gdańsk Medical University
2022
Gdańsk University of Technology
2022
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. PSAM 4 -GlyR modular system based on α7 nicotinic acetylcholine and glycine receptors, which responds inert chemical ligands clinically approved drug varenicline. Here, we demonstrated efficacy this channel silencing both mouse by...
Abstract Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. PSAM 4 -GlyR modular system based on α7 nicotinic acetylcholine and glycine receptors, which responds inert chemical ligands clinically-approved drug, varenicline. Here, we demonstrated efficacy this channel silencing...