Fluorescent carbon nanoparticles (CNPs) 2−6 nm in size with a quantum yield of about ∼3% were synthesized via nitric acid oxidation soot, and this approach can be used for milligram-scale synthesis these water-soluble particles. These CNPs are nanocrystalline predominantly graphitic structure show green fluorescence under UV exposure. Nitric induces nitrogen oxygen incorporation into soot particles, which afforded water solubility light-emitting property; the isolation small particles from...

Fluorescent nanoparticle-based imaging probes have advanced current labelling technology and are expected to generate new medical diagnostic tools based on their superior brightness photostability compared with conventional molecular probes. Although significant progress has been made in fluorescent semiconductor nanocrystal-based biological imaging, the presence of heavy metals toxicity issues associated severely limited application potential these nanocrystals. Here, we report a carbon...

Glutathione (GSH) and oxidized glutathione (GSSG) control cellular function efficiency of anticancer therapy. Reliable detection GSH/GSSG is challenging due to their ultralow concentration (typically femtomolar concentrations) interference by other thiol-based molecules. Here, we report a "turn-off" surface enhanced Raman scattering (SERS)-based approach for reliable GSH GSSG. This exploits GSH-induced replacement probe from the γ-Fe2O3-Au followed Ag growth around that generates...

Although nanoparticle multivalency is known to influence their biological labeling performance, the functional role of largely unexplored. Here we show that folate receptor mediated cellular internalization mechanism 35–50 nm shifts from caveolae- clathrin-mediated endocytosis as increases 10 40 and results in difference subcellular trafficking. We have synthesized functionalized multivalent quantum dot (QD) with varied average numbers per QD between 110 [e.g., QD(folate)10, QD(folate)20,...

The focus of this study was to understand and unravel the interaction silver nanoparticles (AgNPs) with different types Deoxyribonucleic acid (DNA), mammalian bacterial, having base pair compositions. Binding spherical Calf thymus (CT) DNA, Escherichia coli (EC) DNA Micrococcus lysodeikticus (ML) has been studied gain insights into their mode specificity. Interaction AgNPs synthetic also carried out. On basis absorption, thermal melting, isothermal calorimetry viscosity studies, we could...

Nanoparticle-based probes are emerging as alternatives to molecular with several advantages. A variety of water-soluble functional nanoparticles and nanobioconjugates need be prepared tested for this research. Development appropriate coating chemistries is the key in deriving such nanoparticles. Herein we summarize different approaches those have developed compared them context currently available methods, synthesis soluble We focused on conventional ligand exchange, interdigited bilayer...

Although the "turn-on" fluorescence-based detection approach has been widely used in diverse fields, its implementation graphene-based organic pollutant is challenging. Water samples having a low quantity of pollutants poses appreciable challenges sensitive and reproducible detection. We have developed dextran-fluorescein functionalized graphene composite which can reproducibly detect like bisphenol A, 1-napthol, phenol, picric acid nanomolar to picomolar concentration via fluorescence...

In this paper, we report the synthesis of surface-engineered multifunctional Eu:Gd2O3 triangular nanoplates with small size and uniform shape via a high-temperature solvothermal technique. Surface engineering has been performed by one-step polyacrylate coating, followed controlled conjugation chemistry. This creates desired number surface functional groups that can be used to attach folic acid as targeting ligand on nanoparticle surface. To specifically deliver drug molecules in nucleus,...

Plasmonic−fluorescent composite nanoparticles are considered as unique, multifunctional nanoprobes for plasmon- and fluorescence-based imaging detection. However, their synthesis is challenging due to fluorescence quenching of the fluorophore by plasmonic particles most successful methods produce large size (diameter > 50 nm), which limit wider applications. Here we report 20−30 nm diameter plasmonic−fluorescent with reasonable quantum yield (12−16%). These composed 3−6 Au/Ag cores...

Water soluble graphene with various chemical- and biofunctionalities is essential for their different applications. However, exfoliated graphenes are insoluble in water oxide precipitate if they chemically reduced to graphene. We have developed a polyacrylate coating method then it into found that can improve the colloidal stability of both oxide. The coated has been characterized using XPS, FTIR, XRD micro-Raman spectroscopy. primary amine present on backbone used derive glucose...

Multifunctional ZnFe2O4 nanoparticles were successfully synthesized via thermolysis of Fe-oleate and Zn-oleate precursors. Monodisperse, single phase with an average particle size ∼22 nm, exhibiting green emission (λmax∼ 480 nm) ferromagnetism at room temperature (saturation magnetization 48.46 emu gm(-1)) have been formed by this novel approach. By appropriate surface functionalization, these materials converted into smart carriers hydrophobic (water insoluble) drug molecule-curcumin...

In this study, we report a facile synthetic route for the transition of anatase TiO2 nanocube to nanospindle with coexposed {001} and {101} facets on reduced graphene oxide (rGO) platform. Initially, nanocubes/graphene suspension in an ethanol–water solvent mixture was hydrothermally treated at 180 °C various reaction durations perform situ growth simultaneous reduction rGO. All composites resulted formation surface heterojunction formed by embedded rGO sheet. Interestingly, it observed that...

Although it is now well recognized that plasmonic gold/silver nanoparticle based aggregates having electromagnetic hot spots are responsible for high sensitivity in surface-enhanced Raman spectroscopy (SERS), the yield and reproducible production of such nanostructures challenging limit their practical application. Here we show a graphene oxide (GO) approach generating stable with from colloidal nanoparticles leads to highly reproducible, sensitive SERS wide range molecules enhancement...

Although microfluidic approach is widely used in various point of care diagnostics, its implementation surface enhanced Raman spectroscopy (SERS)-based detection challenging. This because SERS signal depends on plasmonic nanoparticle aggregation induced generation stable electromagnetic hot spots and currently available platform this condition difficult to adapt. Here we show that can be adapted using simple paper based system where both the nanomaterials analyte are mobile phase. allows...

Resin immobilized stable, spherical CuO nanoparticles prepared in the presence of cyclodextrin (CD) act as catalysts for liquid phase alcohol oxidation air. The catalytic activity nanocomposites and its green chemistry approach make it superior to related resin-bound Cu(0) nanocomposite. effect chain length electron-donating or -withdrawing groups influence product yield. exhibit good reusability, simple workup procedure, a straightforward aldehyde formation.

Functionalization of gold nanorods is a key issue for their biomedical application, and currently it performed via either electrostatic interaction or thiol based strategy. We have developed polyacrylate coating chemistry that can be used in deriving variety functional with high colloidal stability. The processes introduce primary amines, fluorescein, poly(ethylene glycol) (PEG) on the nanorod surface one step process. While fluorescein incorporation produce fluorescent nanorods, amine...

Multivalency of nanoparticle and associated cooperative binding with biological interface is an important aspect in the development based bioimaging probes. However, preparation such a nanobioconjugate controlled number biomolecules per nanoparticle, typically between 1 100, challenging. Here we report generalized two-step bioconjugation method to prepare nanobioconjugates varied average 100 that can be applied different nanoparticles biomolecules. Following this approach have successfully...

A simple low temperature colloid-chemical synthetic method is reported for size controlled synthesis of hydrophobic silicon nanoparticles in the 1–10 nm range. These show dependent tunable visible emission from blue to red with fluorescence quantum yield range 6–13%. can be subjected extensive surface chemistry without significant loss their properties. The as-synthesized emitting have been transformed into water soluble functional nanoprobes 18 hydrodynamic diameter and 5% used as...

Background and Objectives: The elicitation of a host’s immune−inflammatory responses to overcome oral bacterial biofilm challenges is mediated by numerous cytokines. We explored the role three such cytokines, viz. interleukin (IL)-17, 18 21, measuring their levels in gingival crevicular fluid (GCF) Indian individuals with healthy gingiva, chronic gingivitis, or periodontitis. Materials Method: Ninety systemically were enrolled study on basis predefined criteria categorized into groups 30...

Abstract Folate‐functionalized quantum dots, gold/silver nanoparticles, and magnetic dots have been synthesized used as fluorescence, dark‐field, dual‐imaging probes for the detection of cancer cells tissues. A very efficient generalized folate‐functionalization method has developed various amine‐terminated nanoparticles. The advantages presented approach are that it can be to synthesize a wide range folate‐functionalized nanoparticles number folate molecules per nanoparticle controlled...

We report here ligand-exchange-based synthesis of magnetic-plasmonic and magnetic-fluorescent hybrid nanoparticles such as gamma-Fe(2)O(3)-QD, gamma-Fe(2)O(3)-Au, gamma-Fe(2)O(3)-Ag. In this approach the surface ligands hydrophobic gamma-Fe(2)O(3) are replaced by terminal amine/carboxylate functional groups core-shell type hydrophilic QD/Au/Ag nanoparticle, with a resultant water-soluble nanoparticle. These materials exhibit good colloidal stability, retain property each component...