A5040381185- Bone Tissue Engineering Materials
- Advanced Polymer Synthesis and Characterization
- Advanced Nanomaterials in Catalysis
- Catalytic C–H Functionalization Methods
- Collagen: Extraction and Characterization
- Asymmetric Synthesis and Catalysis
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Chemical synthesis and alkaloids
- Hydrogels: synthesis, properties, applications
- Block Copolymer Self-Assembly
- Tea Polyphenols and Effects
- Nanoplatforms for cancer theranostics
- Polymer Surface Interaction Studies
- Dyeing and Modifying Textile Fibers
- Iron Metabolism and Disorders
- Nanoparticle-Based Drug Delivery
- Pickering emulsions and particle stabilization
- Wound Healing and Treatments
- Silk-based biomaterials and applications
- Dental Health and Care Utilization
- Analytical Chemistry and Chromatography
- Nanocomposite Films for Food Packaging
- Synthetic Organic Chemistry Methods
- Axial and Atropisomeric Chirality Synthesis
Sichuan University
2013-2025
Qingdao University
2019-2024
Affiliated Hospital of Qingdao University
2019-2024
Beijing Radiation Center
2021-2023
State Key Laboratory of Respiratory Disease
2019-2022
Guangzhou Medical University
2017-2022
National Health and Family Planning Commission
2022
Yuhuangding Hospital
2022
Soochow University
2020-2021
Lanzhou City University
2021
Skin injury is a common health problem worldwide, and the highly complex healing process poses critical challenges for its management. Therefore, wound dressings with salutary effects are urgently needed care. However, traditional dressing single function often fails to meet needs of repair, integration multiple functions has been required repair. Herein, Cu2+-chelated epigallocatechin gallate nanoparticles (EAC NPs), radical scavenging, inflammation relieving, bacteria restraining,...
Encapsulation of plant polyphenols with micro-/nano-carriers for enhanced bioavailability has been well documented, but the preparation these carriers and subsequent loading is a multiple process, which generally complicated potentially unexpected negative effects on bioactivity polyphenols. Here, we reported convenient method to assemble carrier-free polyphenol nanoparticles (NPs) based oxidative coupling polymerization. The effectiveness was assessed five different including pyrocatechol...
One phenazopyridine monohydrate (1·H2O), one cocrystal of with phthalimide (2), and three salts benzoic acid (3), 4-hydroxyphenylacetic (4), scaaharin (5) were synthesized, their structures determined by single crystal X-ray diffraction. The results dissolution experiments indicate that the solubility can be enhanced after formations salts, in which apparent value 5is approximately 9 times as large water, 4 is 10 hydrochloride (1·HCl) 0.1 M HCl aqueous solution. stability study demonstrate...
Various nanotechnologies have been extensively developed to prepare nanoparticles with different features for satisfying the requirements of diverse fields, but current achievements are confined material systems limited acquisition desirable properties. Here, we demonstrated a flexible strategy based on broad selectivity amines in condensation green tea polyphenol-EGCG (epigallocatechin gallate), formaldehyde, and rational design preparation versatile nanomaterials. With EGCG as sole system...
Regulating cell migration dynamics is of significance in tissue engineering and regenerative medicine. A 3D scaffold was created to provide various topographies based on a poly(ε-caprolactone) (PCL) self-induced nanohybrid shish-kebab structure, which consisted aligned PCL nanofibers spaced crystal lamellae grown the fibers. Electrospinning applied followed by crystallization. The results resembled natural collagen fibrils an extracellular matrix. This variable microstructure enabled control...
Recently, various nanotechnologies have been developed to improve the current photodynamic cancer therapy, which is generally associated with deficiencies of photosensitizers including poor solubility, inadequate activity, and high dark toxicity. Naturally resourced green tea polyphenols, especially (−)-epigallocatechin-3-gallate (EGCG), are well documented intrinsic antitumor activity. In this work, self-assembly EGCG-conjugated poly(ethylene glycol) (PEG) (EGP) chlorin e6 (Ce6) was...
The size of nanocarriers strongly affects their performance in biological systems, especially the capacity to overcome various barriers before delivering payloads destinations. However, optimum varies at different delivery stages cancer therapy due complicated tumor microenvironment. Relatively large particles are favored for long-term circulation vivo, while smaller contribute deep penetration into tissues. This dilemma stimulates development stimuli-responsive size-shrinking nanocarriers....
Acute kidney injury (AKI) is a common and lethal complication for inpatients in the intensive care unit. Accumulative evidence suggests that severe inflammation oxidative stress are major causes of AKI. Natural polyphenols with potent antioxidative anti-inflammation activities promising treatment AKI, but low bioavailability reduces their therapeutic efficacy vivo. Herein, we reported novel polyphenol-based nanomedicine comprising tea polyphenol nanocarrier insoluble small-molecule drug...
Hydrosilylation of terminal alkenes catalyzed by a scandium metalloligand supported Ni(0) complex were studied. The anti‐Markovnikov products obtained in 62~89% yield, along with the alkanes and 1,1,2,2‐tetraphenyldisilane as minor products. resting‐state complexes hydrosilylation reactions isolated characterized spectroscopic method X‐ray diffraction studies, which represent rare‐example silyl ions via Ni(0)→Sc(III) interaction. catalytic cycle was proposed to be redox neutral center,...
The current strategy using the assembly of medicines and active functional molecules to develop nanomedicines often requires both have a specific matched chemical molecular structure; however, this is difficult predict, execute, control in practical applications. Herein, we reported general solvent-mediated disassembly/reassembly for preparing based on epigallocatechin gallate (EGCG) molecules. polyphenol colloidal spheres (CSs) were self-assembled from condensed EGCG aqueous solution but...
Antioxidative, anti-inflammatory and targeted antibacterial resveratrol nanoparticle-loaded hydrogels (Res NPs/Gel) accelerate infected wound healing.
The understanding of the mineralization collagen for bone formation is a current key theme in tissue engineering and great relevance to fabrication novel biomimetic grafting materials. noncollagenous proteins (NCPs) play vital role are considered be responsible regulating intrafibrillar penetration minerals into fibrils by means their abundant polyanionic domains. In this study, alginate, as NCPs analogue, was introduced mediate self-assembly with simultaneous hydroxyapatite (HA) synthesis....
The noncovalent locking of nanostructured thermoresponsive polyion complexes can be achieved <italic>via</italic> polymerization-induced electrostatic self-assembly (PIESA) using an arginine-like cationic monomer.
Scalable synthesis of multicompartment polyion complex (PIC) systems has been achieved via visible light-initiated RAFT polymerization cationic monomer in the presence anionic diblock copolymer micelles water at 25 °C. This polymerization-induced hierarchical electrostatic self-assembly (hierarchical PIESA) implements structural hierarchy programmable to form PIC and their monolayer colloidal nanosheets nanocages. The play decisive roles such a PIESA access biologically relevant yet...