A5008156406- Adipose Tissue and Metabolism
- Skin Protection and Aging
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- melanin and skin pigmentation
- Muscle Physiology and Disorders
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Genomics, phytochemicals, and oxidative stress
- Ginger and Zingiberaceae research
- Phytochemicals and Antioxidant Activities
- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Bee Products Chemical Analysis
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Bone Metabolism and Diseases
- Polysaccharides and Plant Cell Walls
- Mangiferin and Mango Extracts
- Liver physiology and pathology
- Hair Growth and Disorders
- Oral microbiology and periodontitis research
University of Connecticut
2019-2024
Pukyong National University
2024
Yonsei University
2011-2020
Xanthorrhizol, a natural compound isolated from Curcuma xanthorrhiza Roxb. (Java turmeric), has been reported to possess antioxidant and anticancer properties; however, its effects on metabolic disorders remain unknown. The aim of the present study was evaluate xanthorrhizol (XAN) C. extract (CXE) with standardized XAN hyperglycemia inflammatory markers in high-fat diet- (HFD-) induced obese mice. Treatment (10 or 25 mg/kg/day) CXE (50 100 significantly decreased fasting postprandial blood...
Peroxisome proliferator-activated receptors (PPARs), which are members of the nuclear hormone receptor superfamily, a family ligand-activated transcription factors that consist three isotypes (PPAR α, δ and γ). PPAR activity was previously thought to be limited lipid metabolism glucose homeostasis; however, intensive studies PPARα/γ in recent years have revealed their importance age-related inflammation photoaging as regulators cytokines, matrix metalloproteinases (MMPs) factor-kappa B...
Obesity, a chronic metabolic disorder, is characterized by enlarged fat mass and dysregulation of lipid metabolism. The medicinal plant, Boesenbergia pandurata (Roxb.) Schltr., has been reported to possess anti-oxidative anti-inflammatory properties; however, its anti-obesity activity unexplored. present study was conducted determine whether B. extract (BPE), prepared from rhizome parts, attenuated high-fat diet (HFD)-induced obesity in C57BL/6J mice. molecular mechanism investigated 3T3-L1...
The antiobesity effect of 5,7-dimethoxyflavone (DMF) was evaluated in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese C57BL/6J mice. accumulation lipid droplets triglycerides dose dependently suppressed by DMF through inhibition adipogenesis. downregulated the adipogenic transcription factors (peroxisome proliferator-activated receptor [PPAR]γ, CCAAT/enhancer binding protein [C/EBP]α, sterol regulatory element-binding protein-1c [SREBP-1c]) synthesis enzymes (fatty acid synthase...
Intrinsic skin aging is a complex biological phenomenon mainly caused by cellular senescence and mitochondrial dysfunction. This study evaluated the inhibitory effect of Kaempferia parviflora Wall ex. Baker ethanol extract (KPE) on H2O2-stimulated dysfunction both in vitro vivo. KPE significantly increased cell growth suppressed senescence-associated β-galactosidase activation. inhibited expression cell-cycle inhibitors (p53, p21, p16, pRb) stimulated activators (E2F1 E2F2). H2O2-induced...
Muscle atrophy, which is characterized by a decrease in muscle mass, function, and protein content, can be caused aging, disease, physical inactivity. Red bean or Adzuki (Vigna angularis) has been consumed as an edible legume. possesses various functional properties, such antidiabetes, antiaging, anti-inflammatory, anticancer, hepatoprotective activities. However, little known about its potential inhibitory effect on atrophy. In this study, we investigated the of red extract (RBE) atrophy...
Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) stimulates mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression matrix metalloproteinases (MMPs) inflammatory cytokines. The current study aimed assess anti-photoaging activity Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment...
Abstract Carotenoids are natural pigments utilized as colourants and antioxidants across food, pharmaceutical cosmetic industries. They exist in carbon chain lengths of C 30 , 40 45 50 with variants being the most common. Bacterioruberin (BR) its derivatives part less common carotenoid group, synthesized primarily by halophilic archaea. This study analysed compositional characteristics BR extract (BRE) isolated from ‘ Haloferax marinum ’ MBLA0078, a archaeon seawater near Yeoungheungdo...
Obesity, a metabolic disorder caused by an imbalance between energy intake and expenditure, is accompanied with fat accumulation skeletal muscle atrophy. Kaempferia parviflora Wall. ex Baker, also called black ginger, known to increase physical fitness performance improve metabolism. In this study, we investigated whether extract (KPE) alleviates both obesity atrophy using ob/ob mice. Wild‐type C57BL/6J mice were provided normal diet ad libitum, orally given KPE at dose of 100 mg/kg/day or...
Exercise enhances mitochondrial biogenesis in skeletal muscle. Increased function and content can contribute to the improvement muscle benefits of exercise by increasing response energy demands. The effect standardized Kaempferia parviflora extract (KPE) on performance was accessed L6 myotubes C57BL/6J mice. KPE significantly activated peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) increased density myotubes. also upregulated expression transcription factors for...
Panduratin A, a prenylated chalcone compound, has anti-obesity, anti-bacterial, anti-cancer, anti-inflammatory, and anti-oxidative activities. However, its preventive effect on muscle atrophy not been studied. The purpose of this study was to evaluate the inhibitory panduratin A investigate molecular mechanisms in tumor necrosis factor-alpha (TNF-α)-treated L6 rat skeletal cells. restored myotube diameter reduced by TNF-α. At level, elevated phosphatidylinositol 3 kinase/Akt/mammalian target...
Epigenetic regulation in macrophages plays a crucial role the inflammatory response of cells. We investigated macrophage histone deacetylase 4 (HDAC4) diet-induced obesity and non-alcoholic steatohepatitis using macrophage-specific Hdac4 knockout mice (Hdac4MKO ). floxed control (Hdac4fl/fl ) Hdac4MKO were fed regular chow diet or an obesogenic high-fat/high-sucrose/high-cholesterol (HF/HS/HC) for 12 weeks. The loss Hdac4, compared with Hdac4fl/fl control, aggravated inflammation liver white...
The goal of this study was to determine the role histone deacetylase 9 (HDAC9) in development diet-induced metabolic dysfunction-associated steatohepatitis (MASH) and white adipose tissue (WAT) dysfunctions.
In the present study, effect of standardized Boesenbergia pandurata (Roxb.) Schltr. (fingerroot) ethanol extract on exercise endurance was investigated in L6 rat skeletal muscle cells and C57BL/6J mice. Standardized B. (BPE) increased mitochondrial mass stimulated mRNA expression peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) vitro. BPE also elevated key factors biogenesis function, which are activated by PGC-1α, such as estrogen-related α (ERRα), nuclear...