A5018684122- Congenital heart defects research
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Cardiac Fibrosis and Remodeling
- Bone Metabolism and Diseases
- Fibroblast Growth Factor Research
- Cellular Mechanics and Interactions
- Stress Responses and Cortisol
- Apelin-related biomedical research
- Hydrology and Drought Analysis
- Kruppel-like factors research
- Nitrogen and Sulfur Effects on Brassica
- Nuclear Receptors and Signaling
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Aeolian processes and effects
- Climate variability and models
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Zebrafish Biomedical Research Applications
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Protein purification and stability
Iran Meteorological Organization
2025
Max Planck Institute for Molecular Biomedicine
2022-2025
University of Münster
2022
Max Planck Institute for Heart and Lung Research
2016-2021
Baqiyatallah University of Medical Sciences
2019
Max Planck Society
2016
Tehran University of Medical Sciences
2013
University of Tehran
2010
Abstract Endothelial cells (ECs) respond to shear stress by aligning in the direction of flow. However, how ECs flow complex vivo environments is less clear. Here we describe an endothelial-specific transgenic zebrafish line, whereby Golgi apparatus labelled allow for analysis endothelial polarization. We find that most polarize within 4.5 h after onset vigorous blood and, manipulating cardiac function, observe flow-induced EC polarization a dynamic and reversible process. Based on its role...
Trabeculation is crucial for cardiac muscle growth in vertebrates. This process requires the Erbb2/4 ligand Neuregulin (Nrg), secreted by endocardium, as well blood flow/cardiac contractility. Here, we address two fundamental, yet unresolved, questions about trabeculation: why does it initially occur ventricle and not atrium, how modulated flow/contractility. Using loss-of-function approaches, first show that zebrafish Nrg2a required trabeculation, using a protein-trap line, find expressed...
Complex interplay between cardiac tissues is crucial for their integrity. The flow responsive transcription factor KLF2, which expressed in the endocardium, vital cardiovascular development but its exact role remains to be defined. To this end, we mutated both klf2 paralogues zebrafish, and while single mutants exhibit no obvious phenotype, double display a novel phenotype of cardiomyocyte extrusion towards abluminal side. This requires contractility correlates with mislocalization...
Abstract Zebrafish regenerate damaged myocardial tissue very effectively. Hence, insights into the molecular networks underlying zebrafish heart regeneration might help develop alternative strategies to restore human cardiac performance. While TGF-β signaling has been implicated in regeneration, role of its individual ligands remains unclear. Here, we report opposing expression response during two genes, mstnb and inhbaa , which encode family ligands. Using gain-of-function (GOF)...
Despite great strides in understanding cardiac trabeculation, many mechanistic aspects remain unclear. To elucidate how cardiomyocyte shape changes are regulated during this process, we engineered transgenes to label their apical and basolateral membranes. Using these tools, observed that compact-layer cardiomyocytes clearly polarized while delaminating have lost polarity. The transgene also enabled the imaging of constriction real time. Furthermore, found Neuregulin signaling blood...
Declining bone mass is associated with aging and osteoporosis, a disease characterized by progressive weakening of the skeleton increased fracture incidence. Growth lifelong homeostasis rely on interactions between different cell types including vascular cells mesenchymal stromal (MSCs). As these involve Notch signaling, we have explored whether treatment secreted ligand proteins can enhance osteogenesis in adult mice. We show that bone-targeting, high affinity version Delta-like 4, termed...
ABSTRACT Cardiomyocyte proliferation is crucial for cardiac growth, patterning and regeneration; however, few studies have investigated the behavior of dividing cardiomyocytes in vivo. Here, we use time-lapse imaging beating hearts combination with FUCCI system to monitor proliferating developing zebrafish. Confirming vitro observations, sarcomere disassembly, as well changes cell shape volume, precede cardiomyocyte cytokinesis. Notably, zebrafish embryos young larvae mostly divide parallel...
Abstract This paper revealed the intensifying transboundary dust events in southeastern Turkmenistan near border of Iran, using long-term spatial and statistical data (1980–2023). study introduced definition a new source storms, which is called Sarakhs-Badkhyz region, apart from Karakum Kyzylkum deserts. The mentioned with surface area 100,000 km 2 located northeastern Iran. remotely sensed investigation this was supported local international re-analyzed datasets (e.g., IRIMO, Eumetsat,...
<title>Abstract</title> Blood vessels provide a versatile and adaptable transport system, but recent work has established that endothelial cells, which form the innermost lining of vascular network, are also source molecular signals controlling behavior other cell types in surrounding tissue. Pericytes another essential component vessel wall, comparably little is known about their signaling interactions with populations during organ growth patterning. Here, we have used tissue-specific...
Cardiomyopathies are a group of common heart disorders that affect numerous people worldwide. Left ventricular non-compaction (LVNC) is structural disorder the wall, categorized as type cardiomyopathy mostly caused by genetic disorders. Genetic variations underlying causes developmental deformation wall and resultant contractile insufficiency. Here, we investigated family with several affected members exhibiting LVNC phenotype. By whole-exome sequencing (WES) three members, identified novel...
Mood disorder is one of the complications stroke. The inability to cope with stress also a prognosis depression and anxiety. aim this study assess response system in post stroke patients. Twelve healthy controls (HC) twelve post-stroke patients after filling State-Trait Anxiety Inventory completed Trier Social Stress Test (TSST) which induces acute stress. Salivary samples were collected determine salivary cortisol levels ECG record taken four times (before, right stress, two recoveries: 20...