A5072188335- Ovarian cancer diagnosis and treatment
- Reproductive Biology and Fertility
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Sepsis Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- BRCA gene mutations in cancer
- Cancer Research and Treatments
- Viral-associated cancers and disorders
- S100 Proteins and Annexins
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Neutropenia and Cancer Infections
- Cancer-related molecular mechanisms research
Radboud University Nijmegen
2020-2024
Radboud University Medical Center
2020-2024
University Medical Center
2024
Netherlands Comprehensive Cancer Organisation
2021-2024
Hôpital Farhat Hached
2012
Objective: To assess the association between pretreatment thrombocytosis, anemia, and leukocytosis overall survival (OS) of advanced-stage EOC. Furthermore, to develop nomograms using established prognostic factors hematologic parameters predict OS advanced EOC patients. Methods: Advanced-stage patients treated January 1996 2010 in eastern Netherlands were included. Survival outcomes compared with without thrombocytosis (≥450,000 platelets/µL), anemia (hemoglobin level <7.5 mmol/L), or...
Epithelial ovarian cancer (EOC) patients undergoing splenectomy during cytoreductive surgery represent a small subgroup of patients. Splenic metastases or technical reasons due to extensive upper abdominal disease may require splenectomy. It has been hypothesized that as the spleen's antitumor immunologic functions inhibit growth, promote growth residual observed in other types murine studies. The few studies assessing impact on oncologic outcomes advanced stage EOC have reported...
Objective: The sepsis-induced inflammatory response may potentially affect malignant cells. Recently, a case of spontaneous regression histologically confirmed International Federation Gynecology and Obstetrics (FIGO) stage IIIC epithelial ovarian cancer (EOC) following sepsis was reported. aim our study to assess the impact on oncologic outcomes advanced-stage EOC patients. Methods: Gynecologic patients admitted Intensive Care Unit three centers between 2006 2019 were identified who...
To identify clinicopathologic factors predictive of early relapse (platinum-free interval (PFI) ≤6 months) in advanced epithelial ovarian cancer (EOC) first-line treatment, and to develop internally validate risk prediction models for relapse.All consecutive patients diagnosed with stage EOC between 01-01-2008 31-12-2015 were identified from the Netherlands Cancer Registry. Patients who underwent cytoreductive surgery platinum-based chemotherapy as initial treatment selected. Two models,...
<h3>Objective</h3> To identify clinicopathologic factors predictive of early relapse (i.e. a platinum-free interval (PFI) ≤6 months) in advanced epithelial ovarian cancer (EOC) first-line treatment, and to develop internally validate risk prediction models for relapse. <h3>Methods</h3> All consecutive patients diagnosed with EOC between 01-01-2008 31-12-2015 were identified from the Netherlands Cancer Registry. Patients who underwent debulking platinum-based chemotherapy as initial treatment...
<h3>Objectives</h3> Before using a prediction model in clinical practice, it is essential to externally validate on data not used during development. The objective was two risk models developed the Netherlands for early relapse advanced stage EOC patients an Australian nationwide cohort. <h3>Methods</h3> Advanced diagnosed between 01–01–2002 and 01–06–2006 were identified from Ovarian Cancer Study Outcomes of who underwent cytoreductive surgery platinum-based chemotherapy as primary...
<h3>Introduction/Background</h3> Recently, a case of spontaneous regression histologically confirmed FIGO stage IIIC EOC following sepsis was reported. Experimental studies reported that could induce an antitumor response in other cancers. Studies also shown the persistent immunosuppression seen patients lead to unfavorable oncologic outcomes cancer patients. The aim our pilot study assess impact on advanced <h3>Methodology</h3> Gynecologic admitted Intensive Care Unit (ICU) three centers...
<h3>Introduction/Background*</h3> Epithelial ovarian cancer (EOC) patients undergoing splenectomy during cytoreductive surgery represent a small subgroup of patients. Splenic metastases or technical reasons due to extensive upper abdominal disease may require splenectomy. However, there is limited knowledge on the impact long-term outcome Particularly, it has been hypothesized that as antitumor immunologic functions spleen inhibit growth, promote growth residual postoperative period observed...
<h3>Introduction/Background*</h3> While being recognized as negative prognostic factors for other malignancies (e.g. endometrial and cervical cancer), preoperative anemia leukocytosis have not been established EOC. Similarly, despite the accumulating evidence of thrombocytosis, it remains unclear whether significantly adds to prediction survival individual advanced stage EOC patients in relation more factors. The objective this study was assess impact aforementioned hematologic parameters...