A5080158744- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal and related cancers
- Organ Donation and Transplantation
- Parathyroid Disorders and Treatments
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Genetic Syndromes and Imprinting
- Liver Disease and Transplantation
- Acute Kidney Injury Research
- Renal and Vascular Pathologies
- SARS-CoV-2 and COVID-19 Research
- Erythropoietin and Anemia Treatment
- Dialysis and Renal Disease Management
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
- Biomedical Research and Pathophysiology
- Transplantation: Methods and Outcomes
- Iron Metabolism and Disorders
- Cancer-related molecular mechanisms research
- Bone health and osteoporosis research
- Gene expression and cancer classification
- Cardiac Ischemia and Reperfusion
- Muscle and Compartmental Disorders
University of Veterinary Medicine Vienna
2018-2024
Harvard University
2016-2023
Brigham and Women's Hospital
2016-2023
University of Veterinary Medicine
2021
ORCID
2021
National Institute of Diabetes and Digestive and Kidney Diseases
2018-2020
National Institutes of Health
2018-2020
Krankenhaus der Elisabethinen
2008-2016
Medical University of Vienna
2008-2016
Pediatric Nephrology of Alabama
2013
Background Kidney injury is characterized by persisting inflammation and fibrosis, yet mechanisms which inflammatory signals drive fibrogenesis remain poorly defined. Methods RNA sequencing of fibrotic kidneys from patients with CKD identified a metabolic gene signature comprising loss mitochondrial oxidative phosphorylation expression concomitant increase in regulators enzymes glycolysis under the control PGC1 α MYC transcription factors, respectively. We modeled this switch vivo ,...
Abstract The endogenous repair process can result in recovery after acute kidney injury (AKI) with adaptive proliferation of tubular epithelial cells, but also lead to fibrosis and progressive disease. There is currently limited knowledge about transcriptional regulators regulating these programs. Herein we establish the enhancer super-enhancer landscape AKI by ChIP-seq uninjured repairing kidneys on day two ischemia reperfusion (IRI). We identify key transcription factors including HNF4A,...
Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney heart. Glioma-associated oncogene 1 expressing (Gli1
In Brief Background Increasing evidence accumulates on the central involvement of microRNAs (miRNAs) in disease pathophysiology. We identified distinctly deregulated miRNAs human renal allograft biopsies from patients undergoing acute cellular rejection, antibody-mediated rejection (ABMR), and delayed graft function (DGF). Methods Sixty-five posttransplantation kidney biopsy samples covering 41 cases with (15 vascular 15 interstitial 11 ABMR), 14 DGF cases, 10 protocol serving as controls...
Acute kidney injury (AKI) affects roughly 25% of all recipients deceased donor organs. The prevention post-transplant AKI is still an unmet clinical need. We prospectively collected zero-hour, indication as well protocol biopsies from 166 allografts between 2011 and 2013. In this cohort eight cases with ten matched without pathology serving control group were identified a follow-up biopsy within the first twelve days after engraftment. For set zero-hour subjected to genome wide microRNA mRNA...
Posttransplantation acute renal failure (ARF) occurs in roughly 25% of recipients organs from deceased donors. Inflammation the donor organ is associated with risk for ARF.To determine whether administering corticosteroids to donors reduces incidence and duration ARF more than placebo.Parallel, blocked randomized trial, performed between February 2006 November 2008, computer-generated randomization centralized allocation. Investigators were masked group assignment. (Controlled-trials.com...
Brain death-associated inflammatory response contributes to increased risk of impaired early liver allograft function, which might be counterbalanced by steroid pretreatment the organ donor. The aim this randomized controlled trial was elucidate whether donors improves prevents rejection and prolongs survival.A placebo-controlled blinded clinical performed in three different centers Austria Hungary between 2006 2008. Ninety deceased received either 1000 mg methylprednisolone or placebo 6h...
Several studies investigated the association of histologic scores donor kidney biopsies obtained before engraftment with posttransplant outcomes. Discrimination and goodness fit these scores, however, is low.Thus, we sought to identify elucidate performance molecular rather than markers for this purpose using whole genome gene expression microarray experiments.We identified 80 unique differentially regulated genes in 82 samples, showing no damage versus those damage, based on Chronic...
Transcription enhancers are genomic sequences regulating common and tissue-specific genes their disruption can contribute to human disease development progression.
The vast majority of glomerular filtrated phosphate is reabsorbed in the proximal tubule. Posttransplant phosphaturia common and aggravated by sirolimus immunosuppression. cause induced however remains elusive. Male Wistar rats received or vehicle for 2 7 days (1.5mg/kg). urine phosphate/creatinine ratio was higher serum lower treated rats, fractional excretion elevated renal tubular reabsorption reduced suggesting a hypophosphatemia. PTH rats. FGF 23 levels were unchanged at day but after...
Sequential echocardiography is routinely performed in patients with ESRD listed for transplantation. The benefit of this labor- and time-intensive measure, however, remains unclear. Thus, study elucidated the various obtained routine parameters that best predicted mortality graft survival after renal transplantation.This investigated 553 first transplant recipients Austrian Dialysis Transplant Registry between 1992 2011 who had echocardiographic analysis at transplantation survived least 1...
BACKGROUND The Rhesus (Rh) complex consists of a core comprising the Rh proteins (RhD/RhCE) and Rh‐associated glycoprotein (RhAG) with accessory chains (GPB, LW, CD47). Molecular defects RHAG gene may cause regulator null phenotype without antigen expression or mod decreased expression. STUDY DESIGN AND METHODS Blood samples donor strongly diminished antigens five family members were analyzed by serological phenotyping, flow cytometry, molecular testing, analysis candidate genes. RESULTS...
Biocompatibility of haemodialysis membranes is the most important quality criteria to enable long-term dialysis without major harmful effects. This study sought evaluate differences genomic signatures derived from peripheral blood mononuclear cells (PBMC) in patients undergoing treatment using two different dialyser membranes: one semi-synthetic and full-synthetic membrane.Microarray experiments were conducted PBMCs four stable before after comparing (Hemophan GFS Plus 16) (Hemoflow FX80)...
Background. Anaemia of chronic kidney disease is a well-studied comorbidity, but the molecular predictors post-transplant anaemia remain elusive. Methods. In this case-control study, 25 subjects with anaemia, defined as erythropoiesis-stimulating agent (ESA) requirement within first year, were matched to control recipients comparable demographics no using Austrian Dialysis and Transplant Registry. Genome-wide gene expression analyses deceased donor biopsies obtained immediately before...