A5015383416- Neuroscience and Neuropharmacology Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reaction Mechanisms
- Analytical Chemistry and Chromatography
- Molecular spectroscopy and chirality
- Aldose Reductase and Taurine
- Synthesis and Biological Evaluation
- Fatty Acid Research and Health
- Chemical Reactions and Mechanisms
- Ion channel regulation and function
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Receptor Mechanisms and Signaling
- Phytoestrogen effects and research
- Nicotinic Acetylcholine Receptors Study
- Synthesis and Characterization of Heterocyclic Compounds
- Cannabis and Cannabinoid Research
- Synthesis and biological activity
- Analytical Methods in Pharmaceuticals
- Quinazolinone synthesis and applications
- Cholinesterase and Neurodegenerative Diseases
- Organic and Inorganic Chemical Reactions
- GABA and Rice Research
- Antibiotics Pharmacokinetics and Efficacy
- Mercury impact and mitigation studies
- Prenatal Substance Exposure Effects
University of Modena and Reggio Emilia
2006-2017
Azienda Unita' Sanitaria Locale Di Modena
2016
University of Chieti-Pescara
2000-2006
University of Milan
1990
Abstract Introduction Cannabis sativa L. is a powerful medicinal plant and its use has recently increased for the treatment of several pathologies. Nonetheless, side effects, like dizziness hallucinations, long‐term effects concerning memory cognition, can occur. Most alarming lack standardised procedure to extract cannabis. Indeed, each galenical preparation an unknown chemical composition in terms cannabinoids other active principles that depends on extraction procedure. Objective This...
A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators kainate-activated currents in primary cultures cerebellar granule neurons. Substitution different groups at the 3-position benzothiadiazine ring distinguished between positive negative modulatory properties.
We show that the pseudoperoxidase activity of ferrylmyoglobin (MbIV) promotes oxidative degradation doxorubicin (DOX), an anticancer anthracycline known to induce severe cardiotoxicity. MbIV, formed in vitro by reacting horse heart MbIII with H2O2, caused disappearance spectrum DOX at 477 nm and appearance UV-absorbing chromophores indicated opening its tetracyclic ring. Electron spray ionization mass spectrometry analyses DOX/MbIV ultrafiltrates showed resulted formation 3-methoxyphthalic...
The potential therapeutic benefit of compounds able to activate AMPA receptors (AMPAr) has led the search for new AMPAr positive modulators. On basis crystallographic data benzothiadiazines binding mode in S1S2 GluA2 dimer interface, a set 5-aryl-2,3-dihydrobenzothiadiazine type been synthesized and tested. Electrophysiological results suggested that 5-heteroaryl substituents on benzothiadiazine core like 3-furanyl 3-thiophenyl dramatically enhance activity as modulators with respect IDRA21...
Abstract: Pregnant Sprague‐Dawley rats were treated by gavage with a single dose of 8 mg/kg methyl mercury on gestational day 15. Offspring control and killed at 14, 21 60 days age. The binding characteristics muscarinic receptors labelled in cortical membrane preparation 3 H‐L‐quinuclidinyl benzilate studied together the assessment level same brain area. Furthermore, performance passive avoidance tasks was evaluated weeks old rats. Perinatal exposure to significantly reduced maximum number...
5-Arylbenzothiadiazine type compounds acting as positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-PAMs) have received particular attention in the past decade for their nootropic activity and lack excitotoxic side effects direct agonists. Recently, our research group has published synthesis biological 7-chloro-5-(3-furanyl)-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (1), one most active benzothiadiazine-derived AMPA-PAMs...
Abstract A stopped‐flow bidimensional recycle HPLC (sf‐BD‐rHPLC) configuration has been used to investigate simultaneously the stereo and chemical stability of labile chiral compounds. The single enantiomers a racemate can be separated on column (first dimension) each one trapped in achiral (second that works as reactor.By filling with appropriate aqueous buffers it is possible evaluate enantiomer toward buffer itself. It was reaction products formed where they are by second six valve port....
On-column stopped flow multidimensional HPLC (sfMDHPLC) and dynamic high-performance liquid chromatography were applied to investigate the influence of alkyl substituents at sulfonamidic amino moieties benzothiadiazine 1,1-dioxide derivatives on hydrolysis enantiomerization rate constants. The data obtained indicate presence pyrrolo substituent 3,4 positions rings inhibits hydrolysis, whereas occurs in acidic medium. Hydrolysis rates are quite similar for two benzothiadiazines methyl...
Abstract Benzothiadiazines differently substituted at the sulfonamidic nitrogen atom, stereogenic carbon atom and anilinic have been synthesized fully characterized. Enantioseparation of these compounds has revealed rapid on‐column enantiomerization. The recently developed software DCXplorer successfully applied to calculate enantiomerization kinetic parameters. Enantiomerization barriers 3‐phenyl benzothiadiazines, calculated in this work, indicated a higher rate suggesting that aromatic...