A5070211261- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Sirtuins and Resveratrol in Medicine
- Click Chemistry and Applications
- Cardiovascular Disease and Adiposity
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Prenatal Substance Exposure Effects
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Synthesis and Biological Evaluation
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Chemical Synthesis and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Synthesis and Reactions of Organic Compounds
- Coenzyme Q10 studies and effects
- Phytochemicals and Antioxidant Activities
- Cardiac Ischemia and Reperfusion
- Autophagy in Disease and Therapy
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Signaling Pathways in Disease
- Nephrotoxicity and Medicinal Plants
- Calcium signaling and nucleotide metabolism
Agriculture and Agri-Food Canada
2010-2022
University of Manitoba
2011-2021
St. Boniface Hospital
2010-2021
John Wiley & Sons (United States)
2020
Triangle
2020
Indianapolis Zoo
2020
Kentucky Science Center
2020
University of Winnipeg
2018
Rajiv Gandhi Centre for Biotechnology
2013
University of Kerala
2013
The objective of this study was to examine the effectiveness resveratrol in lowering blood glucose presence standard antidiabetic treatment patients with type 2 diabetes, a randomized placebo-controlled double-blinded parallel clinical trial. A total 66 subjects diabetes were enrolled and randomly assigned intervention group which supplemented at dose 1 g/day for 45 days control received placebo tablets. Body weight, pressure, fasting glucose, haemoglobin A1c, insulin, homeostatic...
BackgroundCardiac hypertrophy is a compensatory enlargement of the heart in response to stress such as hypertension. It beneficial reducing placed on heart. However, when chronic nature, it becomes pathological and leads cardiac dysfunction failure. Current treatments for hypertension failure have proven but are not highly specific associated with side effects. Accordingly, there an important need alternative strategies provide safe effective treatment.
Small arteries from the spontaneously hypertensive rat (SHR) exhibit abnormal stiffness and geometry. This study investigated effects of resveratrol, a polyphenol found in foods such as red grapes, on small SHR.Wistar-Kyoto (WKY) rats SHR were treated with resveratrol (2.5 mg/kg/day) for 10 weeks. Mesenteric artery segments (third-order branches) mounted pressure myograph, vascular geometry mechanical properties calculated lumen media dimensions measured at incremental intraluminal...
Abstract Background In ancient times, plants were recognized for their medicinal properties. Later, the arrival of synthetic drugs pushed it to backstage. However, from being merely used food, are now been widely explored therapeutic value. The current study explores potential skin and flesh extracts a hard-necked Rocambole variety purple garlic in preventing cardiomyocyte hypertrophy cell death. Methods Norepinephrine (NE) was induce adult rat cardiomyocytes pretreated with extracts. Cell...
The purpose of this study was to examine the efficacy an aqueous wild blueberry extract and five polyphenol fractions on in vitro model heart disease. Adult rat cardiomyocytes were pretreated with fractions, then exposed norepinephrine (NE). Cardiomyocyte hypertrophy, cell death, oxidative stress, apoptosis cardiomyocyte contractile function as well activities calpain, superoxide dismutase (SOD) catalase (CAT) measured treated without NE fraction (BF). Four prevented death hypertrophy...
We previously reported that resveratrol, a polyphenol found in red grapes, attenuated changes small artery geometry and stiffness, as well cardiac hypertrophy function the spontaneously hypertensive rat (SHR). However, addition to grapes contain variety of bioactive polyphenols such catechins, anthocyanins, flavonoids. Therefore, we investigated effects grape consumption SHR. Wistar-Kyoto (WKY) rats SHR were treated with freeze-dried powder for 10 weeks. Dilatory, geometry, stiffness...
Cyanidin 3-<italic>O</italic>-glucoside prevents ET1-induced cardiomyocytes hypertrophy and fibroblast differentiation<italic>in vitro</italic>and cardiac abnormalities in SHR.
Obesity is a leading cause of cardiovascular disease. It directly affects heart structure and function contributes to failure. Diet major factor involved in the development obesity along with genetic factors. We examined effects monounsaturated polyunsaturated fatty acid-rich oils on cardiac diet-induced rodent model (DIO). Obese prone (OP) rats were fed high-fat diet (HF; 55% kcal) for 12 weeks; Sprague-Dawley commercial chow served as control. Echocardiography was performed assess all at...
Hypertension is a global health concern for which novel treatment strategies are necessary. The aim of this study to evaluate the efficacy resveratrol (trans-3, 5, 4′-trihydroxystilbene, polyphenol present in grapes) controlling blood pressure participants diagnosed with prehypertension and stage 1 hypertension. In randomized, crossover, double-blinded, placebo-controlled study, 50 (diastolic systolic pressure, 80–89 mmHg 120–139 mmHg, respectively) hypertension systolic, 90–99 140–159 will...
Prenatal ethanol (EtOH) exposure is known to induce adverse effects on fetal brain development. Docosahexaenoic acid (DHA) has been shown alleviate these by up-regulating antioxidant mechanisms in the brain. The liver first organ receive enriched blood after placental transport. Therefore, it could be negatively affected EtOH, but no studies have assessed of DHA liver. This study examined maternal intake status and gene expression key enzymes glutathione system prenatal EtOH exposure....
Diaminothiazoles are novel cytotoxic compounds that have shown efficacy toward different cancer cell lines. They show potent antimitotic and antiangiogenic activity upon binding to the colchicine-binding site of tubulin. However, mechanism action diaminothiazoles at molecular level is not known. Here, we a reversible tubulin with fast conformational change allows lead diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino)thiazole] cause mitotic block. also suppresses microtubule...
Cardiac hypertrophy is the compensatory enlargement of heart aimed at reducing stress induced by either pressure overload or volume (VO); however, sustained leads to cardiac dysfunction. We hypothesize that dysfunction which develops due VO will be associated with abnormalities in sarcoplasmic reticulum (SR) function. Volume was rats aortocaval shunt surgery (‘VO rats’). Echocardiographic measurements were used compare structure and function control rats. The SR isolated from left...
Foods and food bioactives have shown to be effective in preventing some human disease conditions. In this study, we examined the effects of carrot powder, rich carotenoids, as a dietary supplement for prevention cardiac anomalies streptozotocin (STZ) induced type 1 diabetic rats. Male Wistar rats were fed either control or powder containing diet 3 weeks. Type diabetes was with STZ injection (65 mg/kg body weight) half each group. All continued on their respective further 9 Cardiac structural...
In this study, we tested the potential cardioprotective effects of phytoalexin resveratrol (Rsv) on primary adult rat cardiac fibroblasts (CF), myofibroblasts (MF) and cardiomyocytes. Adult CF cardiomyocytes were isolated from male 10-week old Sprague–Dawley rats, cultured for either 24 h (cardiomyocytes) or 48 (CF) before treatments. To isolate MF, trypsinized after in culture, seeded fresh plates prior to treatment. All three cells then treated a further with range Rsv doses. cell...
Long-chain saturated fatty acids, especially palmitic acid (PA), contribute to cardiomyocyte lipotoxicity. This study tests the effects of PA on adult rat contractile function and proteins associated with calcium regulating contraction relaxation. Adult cardiomyocytes were pretreated resveratrol (Resv) then treated PA. For reversal study, incubated prior treatment Resv. Cardiomyocyte contractility, ratio rod- round-shaped cardiomyocytes, Hoechst staining used measure functional morphological...