A5019020152- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Pluripotent Stem Cells Research
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Advanced Breast Cancer Therapies
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Galectins and Cancer Biology
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Signaling Pathways in Disease
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2017-2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2019-2021
High-grade gliomas are the most prevalent and lethal primary brain tumors. They display a hierarchical arrangement with population of self-renewing highly tumorigenic cells called cancer stem cells. These thought to be responsible for tumor recurrence, which make them main candidates targeted therapies. Unbridled cell cycle progression may explain selective sensitivity some treatments. The members Cip/Kip family p21Cip1 p27Kip1 were initially considered as suppressors based on their ability...
Abstract Human embryonic and induced pluripotent stem cells (hESCs hiPSCs) are self-renewing human (hPSCs) that can differentiate to a wide range of specialized cells. Notably, hPSCs enhance their undifferentiated state self-renewal properties in hypoxia (5% O 2 ). Although thoroughly analyzed, implication death is not fully determined. In order evaluate the effect chemically mimicked on cell survival, we analyzed changes viability several aspects apoptosis triggered by CoCl...
Abstract The recurrence of Glioblastoma is partly attributed to the highly resistant subpopulation glioma stem cells. A novel therapeutic approach focuses on restoring apoptotic programs in these cancer cells, as they are often deregulated. BH3-mimetics, targeting anti-apoptotic Bcl-2 family members, emerging promising compounds sensitize cells antineoplastic treatments. Herein, we determined that most abundantly expressed Bcl-xL and Mcl-1, relevant regulating patient-derived cell survival....
The essentially unlimited expansion potential and the pluripotency of human embryonic stem cells (hESCs) make them attractive for cell-based therapeutic purposes. Although hESCs can indefinitely proliferate in culture, unlike transformed cancer cells, they are endowed with a cell-intrinsic property termed mitochondrial priming that renders highly sensitive to apoptotic stimuli. Thus, all attempts broaden insights into apoptosis may be helpful establishing pro-survival strategies valuable its...
Abstract The recurrence of Glioblastoma is partly attributed to the highly resistant subpopulation glioma stem cells. A novel therapeutic approach focuses on restoring apoptotic programs in these cancer cells, as they are often deregulated. BH3-mimetics, targeting anti-apoptotic Bcl-2 family members, emerging promising compounds sensitize cells antineoplastic treatments. Herein, we determined that most abundantly expressed Bcl-xL and Mcl-1, relevant regulating patient-derived cell survival....