A5005850742- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Sports Performance and Training
- Muscle metabolism and nutrition
- Cardiac Health and Mental Health
- Long-Term Effects of COVID-19
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Magnesium in Health and Disease
- Telemedicine and Telehealth Implementation
- Ion Transport and Channel Regulation
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- COVID-19 and Mental Health
- Muscle activation and electromyography studies
- Genetics and Physical Performance
- Sports injuries and prevention
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Innovative Approaches in Technology and Social Development
- Diet and metabolism studies
- Doping in Sports
- Glycogen Storage Diseases and Myoclonus
Witten/Herdecke University
2020-2025
Helios Klinikum Krefeld
2024
Justus-Liebig-Universität Gießen
2011-2023
University of Münster
1997-2013
Institute for Sports Medicine
2004-2008
Max Planck Institute of Molecular Physiology
1993-2001
Exercise and its regulated molecules have myocardial protective effects against cardiac ischemia/reperfusion (I/R) injury. The muscle-enriched miR-486 was previously identified to be upregulated in the exercised heart, which prompted us investigate functional roles of I/R injury further explore potential contributing exercise-induced protection Our data showed that significantly downregulated heart upon Both preventive therapeutic interventions adeno-associated virus 9 (AAV9)-mediated...
Abstract Post-COVID-19 Syndrome (PCS) is a condition with multiple symptoms partly related to dysregulation of the autonomic nerve system. Assessment heart rate variability (HRV) using 24 h Holter-ECG may serve as surrogate characterize cardiac activity. A prospective study including 103 PCS patients (time after infection = 252 days, age 49.0 ± 11.3 years, 45.7% women) was performed and underwent detailed clinical screening, cardiopulmonary exercise testing, Holter monitoring. Data compared...
Intracellular Ca<sup>2+</sup>-changes not only participate in important signaling pathways but have also been implicated a number of disease states including acute pancreatitis. To investigate the underlying mechanisms an experimental model mimicking human gallstone-induced pancreatitis, we ligated pancreatic duct Sprague-Dawley rats and NMRI mice for up to 6 h studied intrapancreatic changes dynamics [Ca<sup>2+</sup>]<sub>i</sub> isolated acini. In contrast bile ligation, obstruction...
Abstract There is currently insufficient evidence about the reliable quantification of exercise load and athlete’s recovery management for monitoring training processes. Therefore, this test–retest study investigated reliability various subjective, muscle force, blood-based parameters in order to evaluate their suitability cycles. 62 subjects completed two identical 60-min continuous endurance bouts intermitted by a four-week period. Before, immediately after, three, 24 h after each bout,...
The aim of the study was to gain insight into time course whole-body electromyostimulation (WB-EMS)-induced inflammatory and endocrine factors over 72 h. Twelve healthy individuals (5 men, 7 women; 33.0 ± 12 years) randomly performed a single 20-minute high-intensity WB-EMS time- intensity-matched circuit training (CT) with 3-week wash-out period. Blood samples were taken pre- post-training at 1.5, 3, 24, 48 h after exercise assess creatine kinase (CK), myoglobin, creatinine, cell...
Abstract Aims The study investigated the association between self-reported physical fitness (SRPF) and mortality in 3,248 participants of Ludwigshafen Risk Cardiovascular Health (LURIC) with a mean follow-up 9.9 years. Methods SRPF was inquired using an 11-point Likert scale on paper-pencil questionnaire at enrolment we defined five distinct classes. Kaplan-Meier survival analysis Cox regression models were used to investigate mortality. Results Participants higher baseline had significantly...
Abstract Background Sarcopenia, defined as loss of muscle mass, quality, and function, is associated with reduced quality life adverse health outcomes including disability mortality. Electromyostimulation (EMS) has been suggested to attenuate the mass function in elderly, sedentary individuals. This study aimed investigate effects EMS on strength during 4 weeks inpatient medical rehabilitation. Methods Patients receiving rehabilitation diagnosed sarcopenia using bioimpedance analysis were...
Introduction: Post-COVID-19 syndrome (PCS) is a multisystemic disorder marked by impaired physical performance as one lead symptom. Since it has been suggested that endurance training part of medical rehabilitation may be effective in improving capacity PCS, this study aimed to compare different modes aerobic training. Methods: A total 110 PCS patients (49.3 ± 11.8 years; 38% women; time after infection = 260.2 127.5 days) underwent detailed clinical screening including symptom-limited...
A better understanding of the cellular and molecular mechanisms that are involved in skeletal muscle adaptation to exercise is fundamentally important take full advantage enormous benefits training offers disease prevention therapy. The aim this study was elucidate transcriptional signatures distinguish endurance-trained untrained muscles young adult males (24 ± 3.5 years). We characterized baseline differences as well acute exercise-induced transcriptome responses vastus lateralis biopsy...
Although the role of calcium (Ca2+) in signal transduction and pathobiology exocrine pancreas is firmly established, magnesium (Mg2+) remains unclear. We have characterized intracellular distribution Mg2+ response to hormone stimulation isolated mouse pancreatic acinar cells studied modulating Ca2+ signaling using microspectrofluorometry digital imaging Ca2+- or Mg2+-sensitive fluorescent dyes as well microelectrodes. Our results indicate that an increase concentrations reduced...
<h3>Background and objective</h3> High calcium concentrations are an established risk factor for pancreatitis. We have investigated whether increasing magnesium affect pathological signals premature protease activation in pancreatic acini, dietary or intraperitoneal administration affects the onset course of experimental <h3>Methods</h3> Pancreatic acini were incubated with up to 10 mM magnesium; [Ca<sup>2+</sup>]<sub>i</sub> (fura-2AM) intracellular (fluorogenic substrates) determined over...
Background The use of eHealth technology in cardiac rehabilitation (CR) is a promising approach to enhance patient outcomes since adherence healthy lifestyles and risk factor management during phase III CR maintenance often poorly supported. However, patients’ needs expectations have not been extensively analyzed inform the design such solutions. Objective goal this study was provide detailed perspective on most important functionalities include an solution assist them maintenance. Methods A...
Marathon running is an extreme physical activity, which determines cardiopulmonary adaption of athletes. Circular RNAs (circRNAs) as potential biomarkers in the blood stream have so far not been tested after such strenuous activities. In silico approaches were performed to identify candidate circRNA MBOAT2. Next, we demonstrated high stability and conservation MBOAT2 well its abundancy human plasma. addition Sanger sequencing specific head-to-tail junction, or back-splice site, established a...
Our study describes the long-term effects of electromyostimulation (EMS) on circulating miRNA levels. The observed increase functional myomiR-206 and -133a levels over 72 h suggests long-lasting muscle proliferation differentiation, whereas cardiovascular miRNAs appear unaffected. findings suggest that provide useful insight into regeneration processes after EMS may thus be used to optimize training effects.