A5060238995- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Fibrosis and Remodeling
- RNA modifications and cancer
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Kruppel-like factors research
- Cardiovascular Effects of Exercise
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Peroxisome Proliferator-Activated Receptors
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
Medizinische Hochschule Hannover
2019-2025
Abstract Inflammation is a hallmark and potent driver of pathological vascular remodelling in atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown mixed results. As an alternative perspective on the conundrum chronic inflammation emerging evidence points towards small subset senescent cells as critical player central node driving Senescent belonging to various cell types are dominant source large array pro-inflammatory cytokines additional plaque...
Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular diseases, but detailed information about the intercellular lncRNA shuttling mechanisms heart is lacking. Here, we report an important crosstalk between cardiomyocytes and fibroblasts mediated by transfer of lncRNA-enriched extracellular vesicles (EVs) context cardiac ischemia. profiling identified two hypoxia-sensitive lncRNAs: ENSMUST00000122745 was predominantly found small EVs, whereas Neat1...
Accumulation of senescent cells is an increasingly recognized factor in the development and progression cardiovascular disease. Senescent different types display a pro-inflammatory matrix remodeling molecular program, known as 'senescence associated secretory phenotype' (SASP), which has roots (epi)genetic changes. Multiple therapeutic options (senolytics, anti-SASP senomorphics epigenetic reprogramming) that delete or ameliorate cellular senescence have recently emerged. Some drugs...
The senescence of vascular smooth muscle cells (VSMCs) has been implicated as a causal pro-inflammatory mechanism for cardiovascular disease development and progression atherosclerosis, the instigator ischemic heart disease. Contemporary limitations related to studying this cellular population senescence-related therapeutics are caused by lack specific markers enabling their detection. Therefore, we aimed profile phenotypical molecular signature senescent VSMCs allow reliable identification....
Marathon running is an extreme physical activity, which determines cardiopulmonary adaption of athletes. Circular RNAs (circRNAs) as potential biomarkers in the blood stream have so far not been tested after such strenuous activities. In silico approaches were performed to identify candidate circRNA MBOAT2. Next, we demonstrated high stability and conservation MBOAT2 well its abundancy human plasma. addition Sanger sequencing specific head-to-tail junction, or back-splice site, established a...
Deficient autophagy has been recently implicated as a driver of pulmonary fibrosis, yet bioinformatics approaches to study this cellular process are lacking. Autophagy-related 5 and 7 (ATG5/ATG7) critical elements macro-autophagy. However, an alternative ATG5/ATG7-independent macro-autophagy pathway was discovered, its regulation being unknown. Using proteome profiling analysis ATG7-deficient human fibroblasts, we aimed identify key microRNA (miR) regulators in autophagy. We have generated...
Myocardial fibrosis is a hallmark of the failing heart, contributing to most common causes deaths worldwide. Several microRNAs (miRNAs, miRs) controlling cardiac were identified in recent years; however, more global approach identify miRNAs involved missing.Functional miRNA mimic library screens applied human fibroblasts (HCFs) annotated inducing proliferation. In parallel, deep sequencing was performed after subjecting HCFs proliferating and resting stimuli, additionally enabling discovery...
Peripheral artery disease (PAD) is a significant burden, particularly among patients with severe requiring invasive treatment. We applied general Machine Learning (ML) workflow and investigated if multi-dimensional marker set of standard clinical parameters can identify in need vascular intervention without specialized intra-hospital diagnostics. This retrospective study involving stable PAD (sPAD, Fontaine Class I II, n = 38) unstable (unPAD, III IV, 18) therapeutic measures. ML algorithms...
Abstract The family of RNA-binding proteins (RBP) functions as a crucial regulator multiple biological processes and diseases. However, RBP function in the clinical setting idiopathic pulmonary fibrosis (IPF) is still unknown. We developed practical silico screening approach for characterization RBPs using multi-sources data information comparative molecular network bioinformatics followed by wet-lab validation studies. Data mining bulk RNA-Sequencing tissues patients with IPF identified...
Rescuing heterotopic heart transplantation (HHT) patients remains a challenge in the field. When 41-year-old patient was transferred to our service, we chose novel approach that is reported herein. The HHT had been performed over 20 years ago, and 2016, because of complications, listed for transplant with 1A status. For first time, SynCardia 50cc total artificial (TAH) (SynCardia Systems, LLC, Tucson, AZ) used an patient. Investigators attained approval use investigational device, as this...
Constant supply of oxygen is crucial for multicellular tissue homeostasis and energy metabolism in cardiac tissue. As a first response to acute hypoxia, endothelial cells (ECs) promote recruitment adherence immune the dysbalanced EC barrier by releasing inflammatory mediators growth factors, whereas chronic hypoxia leads activation transcription factor (TF) battery, that potently induces expression factors cytokines including platelet-derived (PDGF) vascular (VEGF). We report hypoxia-minded,...