A5029074402- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Laser Design and Applications
- Medical Imaging and Pathology Studies
- Anesthesia and Pain Management
- Medical Malpractice and Liability Issues
- Anesthesia and Sedative Agents
- Advanced MRI Techniques and Applications
- Bone and Joint Diseases
- Ethics in medical practice
- Ethics and Legal Issues in Pediatric Healthcare
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Sexual Differentiation and Disorders
- Chemistry and Stereochemistry Studies
- Medical Imaging Techniques and Applications
- Pelvic and Acetabular Injuries
- Medical and Biological Sciences
- Chemical Reactions and Isotopes
- Climate Change and Health Impacts
- Anesthesia and Neurotoxicity Research
- Palliative Care and End-of-Life Issues
- Atomic and Molecular Physics
- Healthcare Decision-Making and Restraints
University Hospitals Sussex NHS Foundation Trust
2014-2025
Royal Sussex County Hospital
2011-2020
Sports Medicine Australia
2020
Princess Royal Hospital
2020
Southern Connecticut State University
2018
British Orthopaedic Association
2015
Peterborough and Stamford Hospitals NHS Foundation Trust
2015
The University of Melbourne
2007-2013
Austin Health
2013
University of Sussex
2008-2013
Summary 1. There should be protocol‐driven, fast‐track admission of patients with hip fractures through the emergency department. 2. Patients require multidisciplinary care, led by orthogeriatricians. 3. Surgery is best analgesic for fractures. 4. Surgical repair occur within 48 hours hospital admission. 5. and anaesthesia must undertaken appropriately experienced surgeons anaesthetists. 6. high‐quality communication between clinicians allied health professionals. 7. Early mobilisation a key...
Summary Increasing numbers of elderly patients are undergoing an increasing variety surgical procedures. There is age‐related decline in physiological reserve, which may be compounded by illness, cognitive decline, frailty and polypharmacy. Compared with younger patients, the at relatively higher risk mortality morbidity after elective (especially) emergency surgery. Multidisciplinary care improves outcomes for patients. Protocol‐driven integrated pathways guide effectively, but must...
The Earth's mean surface temperature is already approximately 1.1°C higher than pre-industrial levels. Exceeding a 1.5°C rise by 2050 will make global adaptation to the consequences of climate change less possible. To protect public health, anaesthesia providers need reduce contribution their practice makes warming. We convened Working Group 45 with recognised interest in sustainability, and used three-stage modified Delphi consensus process agree on principles environmentally sustainable...
We re-analysed prospective data collected by anaesthetists in the Anaesthesia Sprint Audit of Practice (ASAP 1) order to describe associations with linked outcome data.Mortality was 165/11,085 (1.5%) 5 days and 563/11,085 (5.1%) 30 after surgery not associated anaesthetic technique (general vs spinal, or without peripheral nerve blockade).The risk death increased as blood pressure fell: odds ratio (95% CI) for mortality within 0.983 (0.973-0.994) each mmHg intra-operative increment systolic...
Summary Large observational studies of accurate data can provide similar results to more arduous and expensive randomised controlled trials. In 2012, the National Hip Fracture Database extended its dataset include ‘type anaesthesia’ fields. We analysed 65 535 patient record sets determine differences in outcome. Type anaesthesia was recorded 59 191 (90%) patients. Omitting patients who received both general spinal or whom an uncertain type recorded, there no significant difference either...
Concise guidelines are presented for the preparation and conduct of anaesthesia surgery in patients undergoing cemented hemiarthroplasty hip fracture. The Working Party specifically considered recent publications highlighting complications occurring during peri-operative period 1, 2. advice is based on previously published clinical studies.
The care of the elderly with hip fractures and their outcomes might be improved resources targeted by accurate calculation risks mortality morbidity. We used a multicentre national dataset to evaluate recalibrate Nottingham Hip Fracture Score Surgical Outcome Risk Tool. split 9,017 fracture cases from Anaesthesia Sprint Audit Practice into derivation validation data sets logistic regression derive new model co-efficients for death at 30 postoperative days. area (95% CI) under receiver...
<h3>ABSTRACT</h3> Single-cell genomics are enabling technologies, but their broad clinical application remains challenging. We report an easily adaptable approach for single-cell transcriptome and T cell receptor (TCR)-sequencing, matched whole-genome sequencing from tiny, frozen specimens. achieve similar quality biological outputs while reducing artifactual signals compared to data fresh tissue samples. Profiling sequentially collected melanoma samples the KEYNOTE-001 trial, we resolve...
In Brief BACKGROUND: Operating rooms contribute significantly to the increasing volumes and costs of hospital waste. Little is known, however, about doctors' views waste recycling despite their potential influence in improving programs. We surveyed held by anesthesiologists Australia, New Zealand, England regional or metropolitan public private practice. asked following: (1) What proportion consider operating room be important? (2) do respondents identifiable barriers preventing recycling?...
Periprosthetic fractures have considerable clinical implications for patients and financial healthcare systems. This study aims to determine the burden of periprosthetic lower upper limbs in England identify any factors associated with differences treatment outcome.A national, observational study.England.All individuals admitted hospital between 1 April 2015 31 December 2018.Mortality, length stay, change rate admissions.We analysed Hospital Episode Statistics data using International...
Abstract This article lays out the reasons we have for objecting to certain differences between what individuals and in how they relate one another. Our aim is show that there a plurality of be concerned with such not simply absolute amount each individual has considered independently. Furthermore, argue against limited focus on income inequality. Other forms inequality can also matter.
Summary The aim of this audit was to investigate process, personnel and anaesthetic factors in relation mortality among patients with proximal femoral fractures. A questionnaire used record standardised data about 1195 fracture admitted 22 hospitals contributing the Hip Fracture Anaesthesia Network over a 2‐month winter period. Patients were demographically similar between (mean age 81 years, 73% female, median ASA grade 3). However, there wide variation time from admission operation (24–108...
<h3>Background</h3> Several recent studies have demonstrated the use of single nucleotide polymorphism (SNP) arrays for investigation intellectual disability, developmental delay, autism or congenital abnormalities. In addition to LogR 'copy number' data, these provide SNP genotyping data gene level autozygosity mapping, estimating low levels mosaicism, assessing long continuous stretches homozygosity (LCSH), detection uniparental disomy, and 'autozygous' regions. However, there remains...
Summary Significant recent interest has focussed on improving outcomes after emergency laparotomy. This retrospective database analysis estimated the annual incidence and associated inpatient costs of laparotomy in England. Demographic, process outcome data were collected for all patients undergoing Brighton two calendar years (2009–2010). Cost assumed £16 per minute theatre time, £282 day ward bed £1382 critical care costs. National was confirmed from Hospital Episode Statistics Office...
The 2018 Intergovernmental Panel on Climate Change (IPCC) Special Report Global Warming of 1.5°C (SR15) makes sobering reading 1. At the current rate, global warming is likely to reach above pre-industrial levels between 2030 and 2052, this result in far-reaching effects, including: climate change; sea level rise; loss biodiversity; health problems; food water shortage; mass migration; geopolitical insecurity. Adaptation these challenges remains possible below a rise 1.5°C, but would become...
BACKGROUND: Hypotension during anesthesia for surgery hip fracture is common and associated with myocardial injury, stroke, acute kidney delirium. We hypothesized that maintaining intraoperative blood pressure close to patients’ preoperative values would reduce these complications compared usual care. METHODS: A pilot feasibility patient- assessor-blinded parallel group randomized controlled trial. People unilateral aged ≥70 years capacity give consent before were eligible. Participants...
Microarray genome analysis is realising its promise for improving detection of genetic abnormalities in individuals with mental retardation and congenital abnormality. Copy number variations (CNVs) are now readily detectable using a variety platforms major challenge the distinction pathogenic from ubiquitous, benign polymorphic CNVs. The aim this study was to investigate replacement time consuming, locus specific testing microdeletion microduplication syndromes microarray analysis, which...
Abstract Here we report on a family with an inherited rearrangement of chromosome 8q, dir ins(8)(q24.11q13.3q21.13). Individuals the abnormality, which does not appear to be associated deletion material, have manifestations both tricho‐rhino‐phalangeal syndrome (TRPS) and branchio‐oto (BOS). TRPS has been linked previously deletions involving 8q24.11→q24.13, but none described patients in this part 8q had characteristics BOS. The presence breakpoint 8q24.11 without apparent suggests that...