A5016585592- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Collagen: Extraction and Characterization
- Tissue Engineering and Regenerative Medicine
Washington State University Spokane
2020-2022
Georgia Highlands College
2020
Abstract Background Breast cancer cells invading the connective tissues outside mammary lobule or duct immerse in a reservoir of extracellular matrix (ECM) that is structurally and biochemically distinct from their site origin. The ECM spatial network proteins, which not only provide physical support but also serve as bioactive ligands to cells. It becomes evident dimensional, mechanical, structural, biochemical properties are all essential mediators many cellular functions. To better...
Modeling human breast tissue architecture is essential to study the pathophysiological conditions of breast. We report that normal mammary epithelial cells grown in extracellular matrix (ECM) hydrogel formed acini structurally similar those and pig tissues. Type I, II, III V collagens were commonly identified human, pig, mouse ECM. Mammary on certain types or combinations four at levels elasticity. Comparison collagen species tumor ECM revealed common distinct sets within two Elevated...
Tissue extracellular matrix (ECM) is a structurally and compositionally unique microenvironment within which native cells can perform their natural biological activities. Cells grown on artificial substrata differ biologically phenotypically from those tissue microenvironment. Studies examining human ECM structures the biology of in corresponding are lacking. Such investigations will improve our understanding about pathophysiological conditions for better clinical care. We report here normal...