A5055461728- Immune Cell Function and Interaction
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Plant nutrient uptake and metabolism
- Diet, Metabolism, and Disease
- Child Nutrition and Water Access
- Biological Research and Disease Studies
- Nutrition, Genetics, and Disease
- Animal Genetics and Reproduction
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- Digestive system and related health
- Polyamine Metabolism and Applications
- Genetic Associations and Epidemiology
- Viral gastroenteritis research and epidemiology
- Trace Elements in Health
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- FOXO transcription factor regulation
- Genomics and Rare Diseases
- Growth Hormone and Insulin-like Growth Factors
National Institute of Cancer Research and Hospital
2020
National Institute of Cardiovascular Diseases
2018
The cytotoxic T-lymphocyte antigen-4 (CTLA4) is essential in controlling T cell activity within the immune system. Thus, uncovering molecular dynamics of single nucleotide polymorphisms (SNPs) CTLA4 gene critical. We identified non-synonymous SNPs (nsSNPs), examined their impact on protein stability, and sequences associated with them human gene. There were 3134 (rsIDs) our study. Out these, 186 missense variants (5.93%), 1491 intron (47.57%), 91 synonymous (2.90%), while remaining...
Single nucleotide polymorphisms (SNPs) are one of the most common determinants and potential biomarkers human disease pathogenesis. SNPs could alter amino acid residues, leading to loss structural functional integrity encoded protein. In humans, members minichromosome maintenance (MCM) family play a vital role in cell proliferation have significant impact on tumorigenesis. Among MCM members, molecular mechanism how missense complex component 6 (MCM6) contribute DNA replication tumor...
In humans, FOXP gene family is involved in embryonic development and cancer progression. The FOXP4 (Forkhead box protein P4) belongs to this family. plays a crucial role oncogenesis. Single nucleotide polymorphisms are biological markers common determinants of human diseases. Mutations can largely affect the function corresponding protein. Therefore, molecular mechanism nsSNPs needs be elucidated. Initially, SNPs were extracted from dbSNP database total 23124 was found, where 555...
Type 2 diabetes (T2D) has earned widespread recognition as a primary cause of death, disability, and increasing healthcare costs. There is compelling evidence that hereditary factors contribute to the development T2D. Clinical trials in T2D have mostly focused on genes single nucleotide polymorphisms (SNPs) protein-coding areas. Recently, it was revealed SNPs located noncoding areas also play significant impact disease vulnerability. It required for cell type-specific gene expression....
Type 2 diabetes (T2D) is one of the major metabolic disorders in humans caused by hyperglycemia and insulin resistance syndrome. Although significant genetic effects on T2D pathogenesis are experimentally proved, molecular mechanism South Asian Populations (SAPs) still limited. Hence, current research analyzed two Gene Expression Omnibus (GEO) 17 Genome-Wide Association Studies (GWAS) datasets associated with SAP to identify DEGs (differentially expressed genes). The identified were further...
Amino acid transporters (AATs) are essential membrane proteins that transfer amino acids across cells. They necessary for plant growth and development. The lysine histidine transporter (LHT) gene family in maize (Zea mays) has not yet been characterized. According to sequence composition phylogenetic placement, this study found 15 LHT genes the genome. ZmLHT scattered plasma membrane. also analyzed evolutionary relationships, structures, conserved motifs, 3D protein structure, a...
Background & aimsAcute Respiratory Infections (ARI) is a global health problem. Zinc stimulates immune responses and prevents infections. The present study reports the serum zinc level in children with acute respiratory infections, also addresses influences of sociodemographic factors, nutritional status care facility on prevalence infections.MethodsThe was conducted among selected one hundred seven ARI-children under five years age, who were admitted into or attending at outpatient...
Diabetes mellitus (DM) and thyroid dysfunction are the common disorders in human being diabetes many cases is found to be associated with disordered function. This evaluation study was conducted at Z. H Sikder Women’s Medical Collage Hospital (Pvt) Ltd., Gulshan branch, Dhaka, Bangladesh. In this 140 healthy non-diabetic subjects diabetic were investigated for fasting blood sugar (FBS), total triidothyronine (T3), thyroxin (T4), free (FT3), thyroxine (FT4) stimulating hormone (TSH). Out of...
The biodiversity has experienced a significant increase in heavy metal contamination, which direct impact on aquatic environments. Industrial wastewater, municipal waste, burning fossil fuels, mining, and pesticides are the main sources of pollution. Due to its ability produce amount biomass high level stress tolerance, Spirodela polyrhiza (S. polyrhiza) is known as phytoremediation plant. Because their rapid development, simplicity harvesting, potential remove metals from wastewater S....
Background: Global burden of cancer is increasing day by day.As a consequence growing, and ageing population, an important part this increase predicted to concern developing countries like Bangladesh.We have very limited data regarding issue.Aim the study: The aim study was find out profile geriatric cancers in National Institute Cancer Research Hospital, (NICRH), Dhaka, Bangladesh during 2012 2014.Methodology: It retrospective using hospital based registry records from January December...