A5093797294- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- T-cell and B-cell Immunology
- FOXO transcription factor regulation
University of Science and Technology
2024
The cytotoxic T-lymphocyte antigen-4 (CTLA4) is essential in controlling T cell activity within the immune system. Thus, uncovering molecular dynamics of single nucleotide polymorphisms (SNPs) CTLA4 gene critical. We identified non-synonymous SNPs (nsSNPs), examined their impact on protein stability, and sequences associated with them human gene. There were 3134 (rsIDs) our study. Out these, 186 missense variants (5.93%), 1491 intron (47.57%), 91 synonymous (2.90%), while remaining...
In humans, FOXP gene family is involved in embryonic development and cancer progression. The FOXP4 (Forkhead box protein P4) belongs to this family. plays a crucial role oncogenesis. Single nucleotide polymorphisms are biological markers common determinants of human diseases. Mutations can largely affect the function corresponding protein. Therefore, molecular mechanism nsSNPs needs be elucidated. Initially, SNPs were extracted from dbSNP database total 23124 was found, where 555...
Forkhead box protein P4 (FOXP4) is also called hFKHLA, positioning 6p21.1 and play a crucial role in oncogenesis. FOXP4 gene belongs to subfamily P of the forkhead (FOX) transcription factor family it consists other different three proteins. Mutations can largely affect function corresponding protein. Therefore, molecular mechanism nsSNPs need be elucidated. Firstly, were extracted from dbSNP database total 23124 SNPs was found, where 555 non-synonymous, 20525 intron, 1114 non-coding...