A5040936991- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Single-cell and spatial transcriptomics
- Pregnancy and preeclampsia studies
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
Alberta Children's Hospital
2025
University of Calgary
2025
MRC Centre for Reproductive Health
2022-2023
University of Edinburgh
2022-2023
The Queen's Medical Research Institute
2022
Abstract The placenta is the critical interface between mother and fetus, consequently, placental dysfunction underlies many pregnancy complications. Placental formation requires an adequate expansion of trophoblast stem progenitor cells followed by finely tuned lineage specification events. Here, using single-cell RNA sequencing mouse during earliest phases differentiation, we identify gatekeepers cell state, notably Nicol1 , uncover unsuspected trajectories diversification as well...
Uterine adaptations driven by the steroid hormones estrogen and progesterone are pivotal for embryo implantation and, ultimately, a successful pregnancy. Here, we show in mice that genetic ablation of membrane lipid flippase Atp11a causes severe deficits this hormonal response profound defects morphological organization transcriptional profile uterine epithelial compartment where is expressed. -null cells lack tight junctions, luminal epithelium exhibits disruptions to cellular morphology....
Background Heavy menstrual bleeding affects one in four women and negatively impacts quality of life. The levonorgestrel-releasing intrauterine system is an effective long-term treatment but discontinued by many due to unpredictable bleeding, or adverse effects. selective progesterone receptor modulator ulipristal acetate used treat symptomatic fibroids efficacy for the symptom heavy irrespective presence fibroids, unknown. Objectives To determine whether more at reducing burden than after...