A5060735114- Business and Management Studies
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Financial Reporting and Valuation Research
- Synthesis and Catalytic Reactions
- Chromatin Remodeling and Cancer
- Academic Research in Diverse Fields
- Histone Deacetylase Inhibitors Research
- Agricultural and Food Sciences
- Economic Theory and Policy
- Ubiquitin and proteasome pathways
- Chemical Reactions and Isotopes
- Corporate Social Responsibility Reporting
- Epigenetics and DNA Methylation
- Rural Development and Agriculture
- Microtubule and mitosis dynamics
- Environmental Sustainability in Business
- Auditing, Earnings Management, Governance
- Environmental Sustainability and Education
- Innovation Policy and R&D
- Consumer Retail Behavior Studies
- Sugarcane Cultivation and Processing
- Cancer Mechanisms and Therapy
- Multiple Myeloma Research and Treatments
Universidade Federal de Goiás
2023
Universidade Federal de Uberlândia
2018-2023
AstraZeneca (United States)
2013-2019
Centrosome amplification is observed in many human cancers and has been proposed to be a driver of both genetic instability tumorigenesis. Cancer cells have evolved mechanisms bundle multiple centrosomes into two spindle poles avoid multipolar mitosis that can lead chromosomal segregation defects eventually cell death. KIFC1, kinesin-14 family protein, plays an essential role centrosomal bundling cancer cells, but its function not required for normal diploid division, suggesting KIFC1...
Abstract AKT1E17K mutations occur at low frequency in a variety of solid tumors, including those the breast and urinary bladder. Although this mutation has been shown to transform rodent cells culture, it was found be less oncogenic than PIK3CA epithelial cells. Moreover, therapeutic potential AKT inhibitors human tumors with an endogenous is not known. Expression exogenous copies MCF10A increased phosphorylation its substrates, induced colony formation soft agar, lesions mammary fat pad...
BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent gene amplifications. Despite previously described cancer dependencies, it unclear whether amplification events oncogenic in HGSOC. We find that physiologically relevant levels expression isoforms non-transformed ovarian cells result cellular transformation. Transcriptional profiling...
Esta pesquisa busca evidenciar relações entre o ambiente macroeconômico e os indicadores econômico-financeiros dos segmentos empresariais listados na Brasil, Bolsa Balcão (B3). Destaca-se a importância do analista das demonstrações contábeis em considerar aspectos desse ambiente, seja para compreensão de determinados indicadores, ou até mesmo identificação possíveis tendências. Os índices Liquidez, Rentabilidade Estrutura Capital empresas brasileiras listadas B3 foram avaliados por meio uma...
Em virtude de um cenário global marcado pela competição, em que as empresas têm aprimorado seus produtos e processos com o propósito permanecerem no mercado almejando expansão para atender a padrões cada vez mais elevados exigência dos consumidores, Pesquisa Desenvolvimento (P&D) é uma ferramenta eficaz essas entidades por promover aperfeiçoamento inovação. Posto isso, esta pesquisa objetiva verificar se investimento P&D resulta Value Relevance capitais das do setor energia elétrica...
O Brasil ocupa a terceira posição no ranking de importação trigo e tem esse grão como o segundo maior produto em participação na pauta geral importações. Assim, torna ainda mais importante atenção quanto à volatilidade do preço internacional trigo, fim compreender melhor comportamento transmissibilidade para um planejamento eficiente dos agentes cadeia produtiva. Nesse sentido, este estudo por objetivo analisar transmissão os preços domésticos desse seus derivados Brasil. Para atingir...
Abstract The bromodomain and extra-terminal (BET) protein, BRD4 functions as a transcriptional co-activator through recruitment of regulatory complexes to acetylated chromatin. Among all malignancies, the most focal, recurrent gene amplification occurs in high-grade serous ovarian cancer (HGSOC). Despite elucidation dependencies cancer, it is unclear whether can result oncogenic activity, hence serve patient selection strategy for BET inhibitors. To assess potential HGSOC, we assayed...
As escolhas contábeis previstas no CPC 28 (IAS 40) podem afetar as demonstrações das empresas e consequentemente influenciar usuários externos que utilizam para fins de tomada decisão por apresentar mudança procedimento contábil quanto a mensuração propriedades investimento: valor justo ou custo histórico. Uma vez atividades locadoras imóveis estão voltadas ativos investimento, pressupõe-se estas são principais interessadas nas 28. Diante disso, o presente estudo tem objetivo mensurar os...
Abstract Deregulation of the PRC2 components EZH2, SUZ12, and EED plays critical roles in driving aberrant hypermethylation H3K27 tumorigenicity many solid hematological malignancies. Although SAM competitive small molecule inhibitors EZH2 show promising clinical activity PRC2-dependent cancers, preclinical data suggests that resistance can be acquired through secondary mutations abrogate drug target engagement. To address these limitations, we have designed several hetero-bifunctional...
Resumo: A política tecnológica faz parte central da agenda econômica nos países desenvolvidos e dos emergentes, visando gerar capacidade motivar investimentos privados. O objetivo deste estudo foi analisar o reflexo das políticas de incentivo à inovação no desempenho financeiro empresas do setor automobilístico listadas na Brasil, Bolsa Balcão (B3). pesquisa descritiva, natureza quali-quantitativa, realizou coleta dados base Economática®, sites B3. Este enfatiza as ações inovativas...
Objective: Magazine Luiza, founded in November 1957, a national retail icon, started 2011 at B3, with exponential growth the valuation of its shares. This case provides following pedagogical objectives: a) to promote problem analysis, propose and inquire decisions regarding valuation; b) stimulate reflection between theory that supports evaluation purposes way it should be developed applied; c) expand ability relate theoretical assumptions their adequacy reality.
 Methodology: The...
<p>Supplementary Figure 1: Expression of signalling proteins in MCF10A-AKT1WT and MCF10A-AKT1E17K cells grown the presence or absence doxycycline; Supplementary 2: Colony formation soft agar using MCF10A expressing AKT1E17K, AKT1WT, ERBB2V659E RFP under a tet-inducible promoter 1 μg/mL 3: Histograms showing frequencies colonies various diameters; 4: Detection AKT1E17K mutation HBC-x2 xenograft tissue; 5: Effect AKT inhibitors, AZD5363 MK-2206 on pathway biomarkers growth MGH-U3 vitro.</p>
<p>This file contains the supplementary figure legends</p>
Purpose -To identify the relationship between characteristics of board directors and probability dissemination social responsibility reports.Theoretical framework -Considering central role in mitigating conflicts interest, study is based on stakeholder-agency theory.Design/methodology/approach -The sample included 250 companies listed Brazilian Stock Exchange (B3).The data used were collected "Relate or Explain" Report, Economática®, CVM Reference Form, then operationalized using a binary...
<div>Abstract<p>AKT1<sup>E17K</sup> mutations occur at low frequency in a variety of solid tumors, including those the breast and urinary bladder. Although this mutation has been shown to transform rodent cells culture, it was found be less oncogenic than PIK3CA epithelial cells. Moreover, therapeutic potential AKT inhibitors human tumors with an endogenous AKT1<sup>E17K</sup> is not known. Expression exogenous copies MCF10A increased phosphorylation its...
O objetivo do estudo foi analisar a mensuração dos custos e precificação produtos setor de hortifrúti, propor um modelo preço venda específico para os deste setor. Realizou-se caso em empresa supermercadista, onde pode-se observar o modus operandi da composição precificação, por meio observação direta entrevista com gestor. Os principais resultados demonstram que fixos são parametrizados pelo sistema gestão (ERP) considerando média relação entre as despesas gerais faturamento. variáveis...
Abstract Mutations of MAPK1 E322K are observed in ∼8% cervical ∼1% and head neck cancer but there is currently little evidence their impact on the ERK pathway. This study evaluated mutation pathway output feedback using an inducible system pTRIPZ MCF10A immortalised cells. Expression following doxycycline induction reduced RSK phosphorylation T359/S363 increased pELK1 S383. DUSP6 protein levels were also expressing mutant compared to WT. Pathway was determined mRNA MEK signature (Dry et al....
Abstract KIFC1, a kinesin-14 family protein, plays an essential role in centrosomal bundling, strategy employed by cancer cells to avoid multipolar mitosis the presence of amplified centrosomes. However, its function is not required for normal diploid cell division, suggesting that KIFC1 attractive therapeutic target human cancers. We have recently reported first small molecule inhibitor AZ82 [1]. binds specifically KIFC1/microtubule (MT) binary complex, and inhibits MT-stimulated enzymatic...
Abstract Aberrant fibroblast growth factor (FGF) signaling has been implicated in tumorgenesis and chemoresistance a number of cancer types including lung, breast, gastric, endometrial as well others. The small molecule FGF receptor (FGFR) kinase inhibitor, AZD4547, is currently Phase I/II clinical development (gastric, squamous lung breast cancer) to test the FGFR amplified tumor-driven hypothesis. Our aim was identify characterize additional genetic subtypes based on reported aberrations...
<div>Abstract<p>AKT1<sup>E17K</sup> mutations occur at low frequency in a variety of solid tumors, including those the breast and urinary bladder. Although this mutation has been shown to transform rodent cells culture, it was found be less oncogenic than PIK3CA epithelial cells. Moreover, therapeutic potential AKT inhibitors human tumors with an endogenous AKT1<sup>E17K</sup> is not known. Expression exogenous copies MCF10A increased phosphorylation its...
<p>This file contains the supplementary figure legends</p>
<p>Supplementary Figure 1: Expression of signalling proteins in MCF10A-AKT1WT and MCF10A-AKT1E17K cells grown the presence or absence doxycycline; Supplementary 2: Colony formation soft agar using MCF10A expressing AKT1E17K, AKT1WT, ERBB2V659E RFP under a tet-inducible promoter 1 μg/mL 3: Histograms showing frequencies colonies various diameters; 4: Detection AKT1E17K mutation HBC-x2 xenograft tissue; 5: Effect AKT inhibitors, AZD5363 MK-2206 on pathway biomarkers growth MGH-U3 vitro.</p>