A5019105551- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Kawasaki Disease and Coronary Complications
- Inflammatory Biomarkers in Disease Prognosis
- Inflammation biomarkers and pathways
- Venous Thromboembolism Diagnosis and Management
- Health disparities and outcomes
- Cardiovascular Function and Risk Factors
- Frailty in Older Adults
- COVID-19 and healthcare impacts
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Employment and Welfare Studies
- Cardiac Ischemia and Reperfusion
- Diabetes Treatment and Management
- Coronary Artery Anomalies
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Metabolism, Diabetes, and Cancer
Cardiovascular Research Foundation
2024-2025
Methodist Hospital
2024
Houston Methodist
2023-2024
Memorial Ankara Hospital
2020-2023
City Hospital
2021
City Clinical Hospital
2021
Sağlık Bilimleri Üniversitesi
2020-2021
Wellcome Sanger Institute
2017-2021
Beth Israel Deaconess Medical Center
2018-2020
Deaconess Hospital
2018-2020
The addition of a claims-based frailty metric to traditional comorbidity-based risk-adjustment models for acute myocardial infarction (AMI), heart failure (HF), and pneumonia improves the prediction 30-day mortality readmission. This may have important implications hospitals that tend care frail populations participate in Centers Medicare & Medicaid Services value-based payment programs, which use these risk-adjusted metrics determine reimbursement.To whether measures improved outcomes...
Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular being the main cause of death. Cells from HGPS patients accumulate progerin, permanently farnesylated, toxic form Lamin A, disrupting nuclear shape and chromatin organization, leading to DNA-damage accumulation senescence. Therapeutic approaches targeting farnesylation or aiming reduce progerin levels have provided only partial health...
Abstract Aims We sought to identify the prevalence and related outcomes of frail individuals undergoing transcatheter mitral valve repair aortic replacement (TAVR). Methods results Patients aged 65 older were included in study if they had at least one procedural code for or TAVR between 1 January 2016 31 December Centers Medicare Medicaid Services Provider Review database. The Hospital Frailty Risk Score, an International Classification Diseases, Tenth Revision (ICD-10) claims-based score,...
Financial stress (FS) during young adulthood may have lasting effects on financial security, physical health, and overall wellbeing. This study examines the burden, social determinants mental health consequences of experienced FS among adults in United States, based objective measures stress. We studied aged 18-26 years using pooled data from 2013-18 National Health Interview Survey. was assessed as an aggregate score (6-24) worry about six life tasks: paying for: monthly bills, housing...
Abstract Sphingosine-1-phosphate (S1P) is lipid messenger involved in the regulation of embryonic development, immune system functions, and many other physiological processes. However, mechanisms S1P transport across cellular membranes remain poorly understood, with several ATP-binding cassette family members spinster 2 (Spns2) member major facilitator superfamily known to mediate cell culture. Spns2 was also shown control activities zebrafish vivo play a critical role cardiovascular...
The aim of this study was to investigate the relation between native thiol/disulfide ratio (TDR) and severity coronary atherosclerosis as assessed by Syntax score (SXscore) in patients with non-ST elevation myocardial infarction (NSTEMI) who underwent angiography.A total 290 NSTEMI angiography, were included January August 2014. Baseline angiography determined SXscore. divided into two groups: one low SXscores (< 23) other high (≥ 23).TDR significantly lower (p < 0.001). In-hospital...
Background Monocyte to HDL-C ratio (MHR) represents a simple assessment method for inflammatory status. The aim of the present study was investigate whether MHR may be short-term and long-term prognostic value in ST-elevation myocardial infarction (STEMI) patients who have undergone primary percutaneous coronary intervention (PCI). Materials methods A total 682 consecutive STEMI underwent successful PCI between March 2013 September 2015 were included this study. Patients divided into groups...
We assessed the prognostic role of serum endocan level in patients with ST-segment elevation myocardial infarction (STEMI) and compared results a normal coronary angiography group. A total 133 were included study (88 STEMI 45 arteries). The SYNTAX score was determined based on baseline angiogram. Multivariate logistic regression analysis indicated that independently correlated presence STEMI. Moreover, high-sensitivity C-reactive protein (hsCRP), peak troponin I, left ventricular ejection...
Recent studies have emphasized the intricate relationship between obesity and psychological distress, unraveling complex interplay of biological, psychological, sociocultural factors. However, a conspicuous knowledge gap persists in understanding association severity particularly young adults, marked by limited empirical data.
Increased white blood cell (WBC) count is associated with increased mortality in patients ST-segment elevation myocardial infarction (STEMI). We aimed to evaluate predictive value of admission WBC mean platelet volume (MPV) ratio (WMR) on prognosis undergoing primary percutaneous coronary intervention (pPCI) for STEMI.A total 2,603 consecutive STEMI who underwent pPCI were recruited the study. Follow-up data obtained from digital records, patient files or by telephone interview patients,...
Background Prospectively collected frailty markers are associated with an incremental 1-year mortality risk after transcatheter aortic valve replacement (TAVR) compared comorbidities alone. Whether information on captured retrospectively in administrative billing data is similarly predictive of long-term TAVR unknown. We sought to characterize the prognostic importance factors as identified healthcare records comparison validated measures for prediction TAVR. Methods and Results Adult...
The aim of this study was to determine the hematologic parameter with highest diagnostic differentiation in identification massive acute pulmonary embolism (APE).A retrospective performed on patients diagnosing APE between June 2014 and 2016. All radiological laboratory parameters were scanned through electronic information management system hospital. PLR obtained from ratio platelet count lymphocyte count, NLR neutrophil WMR white blood cell mean volume ratio, MPR RPR red distribution width...
In the current study, we aimed to develop and validate a model, based on our nationwide centralized coronavirus disease 2019 (COVID-19) database for predicting death. We conducted an observational study (CORONATION-TR registry). All patients hospitalized with COVID-19 in Turkey between March 11 June 22, 2020 were included. developed model validated both temporal geographical models. Model performances assessed by area under curve-receiver operating characteristic (AUC-ROC or c-index), R2 ,...
Introduction Understanding the role of social determinants health as predictors mortality in adults with diabetes may help improve outcomes this high-risk population. Using population-based, nationally representative data, study investigated cumulative effect unfavorable on all-cause diabetes. Research design and methods We used data from 2013–2018 National Health Interview Survey, linked to Death Index through 2019, for ascertainment. A total 47 individual were categorize participants...