A5001367467- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Boron Compounds in Chemistry
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Graphene and Nanomaterials Applications
- Plant biochemistry and biosynthesis
University of Kent
2018-2020
Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapted vincristine (UKF-NB-3rVCR1) doxorubicin (UKF-NB-3rDOX20). Doxorubicin-loaded displayed increased activity UKF-NB-3rVCR1 UKF-NB-3rDOX20 cells relative solution, but not cells. were re-sensitised by nanoparticle-encapsulated level more pronounced...
Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer cells. Drug encapsulation into nanoparticles has been shown to bypass efflux-mediated drug resistance, but there also conflicting results. To investigate whether easy-to-prepare made well-tolerated polymers may circumvent transporter-mediated...
Abstract Nanoparticles are under investigation as carrier systems for anti-cancer drugs. They have been shown to accumulate in cancer tissues through the enhanced permeability and retention (EPR) effect, reduce toxicity non-target tissues, protect drugs from preliminary inactivation. However, nanoparticle preparations not commonly compared their effects at cellular level. Here, we prepared doxorubicin-loaded nanoparticles based on poly(lactic- co -glycolic acid) (PLGA), polylactic acid...
Willow (Salix spp.) is well known as a source of medicinal compounds, the most famous being salicin, progenitor aspirin. Here we describe isolation, structure determination, and anti-cancer activity cyclodimeric salicinoid (miyabeacin) from S. miyabeana dasyclados. We also show that capability to produce such dimers heritable trait how variation in structures natural miyabeacin analogues derived via cross-over Diels-Alder reactions pools ortho-quinol precursors. These transient ortho-quinols...
Abstract Resistance to systemic drug therapies is a major reason for the failure of anti-cancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapted vincristine (UKF-NB-3 r VCR 1 ) doxorubicin DOX 20 ). Doxorubicin-loaded displayed increased activity cells relative solution, but not cells. were resensitised by nanoparticle-encapsulated level more pronounced resistance phenotype than...