A5019065951- Plant biochemistry and biosynthesis
- Biochemical and biochemical processes
- Plant tissue culture and regeneration
- Phytochemicals and Antioxidant Activities
- Arsenic contamination and mitigation
- Plant Gene Expression Analysis
- Toxin Mechanisms and Immunotoxins
- Parkinson's Disease Mechanisms and Treatments
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Heavy Metal Exposure and Toxicity
- Edible Oils Quality and Analysis
- Phytochemistry and Biological Activities
- Biofuel production and bioconversion
- Heavy metals in environment
Rothamsted Research
2011-2024
Stellenbosch University
2020
University of Amsterdam
2020
• Inorganic arsenic (iAs) is a ubiquitous human carcinogen, and rice (Oryza sativa) the main contributor to iAs in diet. Methylated pentavalent As species are less toxic routinely found plants; however, it currently unknown whether plants able methylate As. Rice, tomato (Solanum lycopersicum) red clover (Trifolium pratense) were exposed iAs, monomethylarsonic acid (MMA(V)), or dimethylarsinic (DMA(V)), under axenic conditions. Rice seedlings also grown two soils nonsterile flooded...
Willow (Salix sp.) is a historically well-known herbal medicine that provided the lead compound (salicin) for discovery of aspirin, one most successful plant derived drugs in human medicine. During metabolomics screen 86 Salix species contained UK National Collection, we have discovered, isolated and fully characterised new natural salicinoid - salicin-7-sulfate. This molecule may important pharmacological actions need to be considered determining efficacy safety willow medicines.
Sinapine (sinapoylcholine) is an antinutritive phenolic compound that can account for up to 2% of seed weight in brassicaceous oilseed crops and reduces the suitability their protein-rich meal use as animal feed. biosynthesis draws on hydroxycinnamic acid precursors produced by phenylpropanoid pathway. The 4-vinyl derivatives several acids have industrial applications. For example, phenol (4-hydroxystyrene) a building block range synthetic polymers applied resins, inks, elastomers, coatings....
There is an intense search for natural compounds that can inhibit the oligomerization and fibrillation of α-synuclein (α-Syn), whose aggregation key to development Parkinson's disease (PD). Rosa damascena a medicinal herb widely used in Middle Eastern food, ceremonies, perfumes. The known contain many different polyphenols. Here we investigated existence α-Syn inhibitors R. extract. Different HPLC fractions extract were assessed toxicity assays. most active led formation more oligomers but...
The salicinoids are phenolic glycosides that characteristic secondary metabolites of the Salicaceae, particularly willows and poplars. Despite well-known pharmacology salicin, led to development aspirin >100 years ago, biosynthetic pathways leading have yet be defined. Here, we describe identification, cloning, biochemical characterization SpUGT71L2 SpUGT71L3-isozymic glycosyltransferases from Salix purpurea-that function in glucosylation ortho-substituted phenols. best substrate vitro was...
Willow (Salix spp.) is well known as a source of medicinal compounds, the most famous being salicin, progenitor aspirin. Here we describe isolation, structure determination, and anti-cancer activity cyclodimeric salicinoid (miyabeacin) from S. miyabeana dasyclados. We also show that capability to produce such dimers heritable trait how variation in structures natural miyabeacin analogues derived via cross-over Diels-Alder reactions pools ortho-quinol precursors. These transient ortho-quinols...
An investigation of phenolic glycosides extracted from Salix germplasm revealed that arbusculoidin (benzyl 1-O-β-d-glucopyranosyl-1-hydroxy-6-oxo-2-cyclohexenyl carboxylate) and its enolic 6-glycoside isomer, isoarbusculoidin, are widespread across the family. analysis natural hybrid species progeny a willow breeding programme demonstrated putative biosynthetic pathway leading to salicinoid family runs in parallel "benzyl"-based arbusculoidin. The introduction known Diels-Alder reaction...