A5101897739- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Stress Responses and Cortisol
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Protein Kinase Regulation and GTPase Signaling
- Cell Adhesion Molecules Research
- Genomics and Chromatin Dynamics
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Visual perception and processing mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Gaze Tracking and Assistive Technology
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Prostate Cancer Treatment and Research
- Drug-Induced Hepatotoxicity and Protection
- Clostridium difficile and Clostridium perfringens research
- Synthesis and biological activity
Sun Yat-sen University
2016-2024
City University of Hong Kong
2021-2023
China Pharmaceutical University
2021-2023
Shandong University of Traditional Chinese Medicine
2020
Abstract Background Targeted drugs are not quite effective for prolonging the survival of patients with gastric cancer due to off-target effects as well tumor immune escape mechanisms. Circular RNAs widely exist in regions biomarkers and can be developed drug targets. Methods Western blot, QRT-PCR, fluorescence situ hybridization, flow cytometry were used investigate function hsa_circ_0136666 promoting proliferation cells. Tissue immunofluorescence, enzyme-linked immunosorbent assay (ELISA),...
Protein lysine methyltransferases G9a and GLP, which catalyze mono- di-methylation of histone H3K9 nonhistone proteins, play important roles in diverse cellular processes. Overexpression or dysregulation GLP has been identified various types cancer. Here, we report the discovery a highly potent selective covalent inhibitor 27 G9a/GLP via structure-based drug design approach following structure–activity relationship exploration potency optimization. Mass spectrometry assays washout...
Although fear memory formation is essential for survival and fear-related mental disorders, the neural circuitry mechanism are incompletely understood. Here, we utilized trace conditioning to study of in mice. We identified entorhinal cortex (EC) as a critical component sensory signaling amygdala. adopted both loss-of-function gain-of-function experiments demonstrate that release cholecystokinin (CCK) from EC required formation. discovered CCK-positive neurons project lateral nuclei amygdala...
PRMT5 is a major type II protein arginine methyltransferase and plays important roles in diverse cellular processes. Overexpression of implicated various types cancer. Many efforts have been made to develop potent selective inhibitors, the most which usually derived from nucleoside structures. Here, we designed novel series non-nucleoside inhibitors through structure-aided drug design approach. SAR exploration metabolic stability optimization led discovery compound 41 as inhibitor with good...
Nuclear receptor receptor-related orphan γ (RORγ) is a ligand-dependent transcription factor and has been established as key player in castration-resistant prostate cancers (CRPC) by driving androgen (AR) overexpression, representing potential therapeutical target for advanced cancers. Here, we report the identification of first-in-class RORγ covalent inhibitor 29 via structure-based drug design approach following structure–activity relationship (SAR) exploration. Mass spectrometry assay...
Sodium tanshinone IIA sulphonate, a water-soluble derivative of IIA, has been proven to possess versatile biological properties, but its pharmacological effect on tracheal smooth muscle remains elusive. This paper presents study the relaxant and underlying mechanisms sodium sulphonate mouse muscle. The was evaluated in rings using mechanical recording system. Intracellular Ca2+ concentration measured primary cultured cells confocal imaging results showed that induced dose-dependent...
SH2 domains have been recognized as promising targets for various human diseases. However, targeting with phosphopeptides or small-molecule inhibitors derived from bioisosteres of the phosphate group is still challenging. Identifying novel to achieve favorable in vivo potency urgently needed. Here, we report feasibility STAT3-SH2 domain a boronic acid and identification highly potent inhibitor compound 7 by replacing carboxylic 4 acid. Compound shows higher binding affinity, better cellular...
The attentional effect on visual working memory (VWM) has been a heated research topic in the past two decades. Studies show that VWM performance for an attended item can be improved by cueing its two-dimensional (2D) spatial location during retention. However, few studies have investigated of selection three-dimensional setting, and it remains unknown whether depth information produce beneficial effects 2D representations similar to information. Here we conducted four experiments,...
The objective of the present work was to study role Cxcl1 in cerebral ischemia-reperfusion (I/R) injury and in-depth explore its pathogenesis.The expression based on public data analyzed. Then, we constructed an oxygen glucose deprivation/reoxygenation (OGD/R) model vitro using mice brain microvascular endothelial cells (BMECs) simulate I/R vivo.The results quantitative real-time polymerase chain reaction assay uncovered that showed higher while miR-429 lower BMECs damaged by OGD/R, whereas...
Abstract Although the neural circuitry underlying fear memory formation is important in fear-related mental disorders, it incompletely understood. Here, we utilized trace conditioning to study of memory. We identified entorhinal cortex (EC) as a critical component sensory signaling amygdala. Moreover, used loss function and rescue experiments demonstrate that release neuropeptide cholecystokinin (CCK) from EC required for formation. discovered CCK-positive neurons extend lateral nuclei...
Abstract Alteration of intestinal flora is usually associated with various gastrointestinal diseases.Microbial homeostasis can enhance host immune tolerance and regulate balance.Our previous studies have found that the peptidoglycan framework Lactococcus lactis ( L.lactis ),gram positive enhancer matrix particles (GEM),improved diversity significantly increased relative abundance Bacteroidetes in colitic mice.Of note, Bacteroides fragilis B.fragilis ) alleviate inflammation by promoting...