A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding carbohydrazide 2 with various carbonyl compounds. Also, dehydrative-cyclocondensation active methylene compounds or anhydrides gave the respective pyarzole pyrazine derivatives. The structures newly synthesized established based on spectroscopic evidences and their alternative syntheses. Additionally, anti-viral activity all products was tested against SARS-CoV-2 main protease (Mpro) using...

A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by subjection reactions carbothioamide derivative and hydrazonoyl chlorides (or α-haloketones). The cytotoxicity the compounds was evaluated against colon carcinoma cell line (HCT-116), liver (HepG2), breast (MDA-MB-231), demonstrated encouraging activity. Furthermore, when representative products assessed for toxicity normal cells, minimal toxic effects observed, indicating their potential safety use in...

Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H-indoles 3a,b. Also, new [1,3,4]thiadiazoles 12a,b, [1,2,4]triazoles 15a,b and [1,3,4]oxadiazoles 19a,b, with indole moieties, were prepared by cyclization 1-[(2-methyl-1H-indole)-3-carbonyl]thiosemicarbazides 8a,b under microwave irradiation using...

In recent years, nanotechnology has become a considerable research interest in the area of preparation nanocatalysts based on naturally occurring polysaccharides. Chitosan (CS), as biodegradable and biocompatible polysaccharide, is successfully utilized an ideal template for immobilization metal oxide nanoparticles. this study, zinc nanoparticles have been doped within chitosan matrix at dissimilar weight percentages (5, 10, 15, 20, 25 wt.% CS/ZnO) fabricated by using simple solution casting...

A novel series of bis- (Abdelhamid et al., 2017, Banerjee 2018, Bharanidharan 2022)thiadiazoles was synthesized from the reaction precursor dimethyl 2,2'-(1,2-diphenylethane-1,2-diylidene)-bis(hydrazine-1-carbodithioate) and hydrazonyl chlorides in ethanol under ultrasonic irradiation. Spectral tools (IR. NMR, MS, elemental analyses, molecular dynamic simulation, DFT LUMO HOMO) were used to elucidate structure isolated products. Molecular docking for precursor, 3 ligands 6a-i two COVID-19...

A novel catalytic approach for the synthesis of symmetric and asymmetric azines has been developed. The environmentally benign protocol was achieved via condensation 1-[(2-thienyl)ethylidene]hydrazine (1) with different aromatic aldehydes 2a–h acetyl heterocyclic compounds (4, 6, 8, 10, 12) in presence cellulose sulfuric acid (CSA) as green catalyst. These procedures offer an interesting method large-scale industrial manufacture due to their high percentage yield, mild reaction conditions,...

Reactions of ethylidenethiosemicarbazide 3 with DMAD 4 or substituted methylenemalononitriles 8 gave thiazolidin-4-one 6 1,3-thiazine derivatives (10, 11), respectively.Also, treatment hydrazonoyl halides 12a-i, -haloketones 15a-d, and chloroacetic acid 18 afforded the corresponding arylazothiazoles 14a-i, thiazoles 17a-d, thiazolin-4-one derivative 20, respectively.The structures synthesized products were confirmed by IR, 1 H NMR, 13 C NMR mass spectral techniques.The anticancer activity...

Novel N-arylpyrazole-containing enaminones 2a,b were synthesized as key intermediates. Reactions of with active methylene compounds in acetic acid the presence ammonium acetate afforded substituted pyridine derivatives 5a-d. Enaminones also reacted aliphatic amines such hydrazine hydrate and hydroxylamine hydrochloride to give bipyrazoles 8a,b pyrazolylisoxazoles 9a,b, respectively. On other hand, treatment a heterocyclic amine its diazonium salt yielded respective...

Highly efficient one-pot solvent-free grinding method was reported for synthesis of chalcones 3a-j, 5a,b, 7 and bis-chalcones 9, 11. Cyclodehydration 11 3 with hydrazine derivatives under solvent- free afforded bis-pyrazolines 12a,b, 13a,b pyrazoline 14a-g, respectively. In a similar manner, hydroxylamine hydrochloride the employed reaction conditions gave bis-isoxazolines 15, 16 isoxazoline 17a-e, The antioxidant activity selected products studied using 1,1-diphenyl-2-picrylhydrazyl radical...

A chitosan-MgO hybrid nanocomposite was prepared using a simple chemical precipitation method and characterized Fourier transform spectroscopy (FTIR), elemental analysis (EDX), scanning electron microscopy (SEM). The served as powerful ecofriendly basic catalyst under microwave irradiation in the synthesis of two novel series 5-arylazo-2-hydrazonothiazoles 4a⁻j 2-hydrazono[1,3,4]thiadiazoles 8a⁻d, incorporating sulfonamide group. structures synthesized products were elucidated by spectral...

Recently, Strontium oxide (SrO) nanoparticles (NPs) and hybrids outperformed older commercial catalysts in terms of catalytic performance. Herein, we present a microwave-assisted easy situ solution casting approach for the manufacture strontium doped within naturally occurring polymer, chitosan (CS), at varying weight percentages (2.5, 5, 10, 15, 20 wt.% SrO/chitosan). To construct new hybrid material as thin film, produced nanocomposite solutions were cast petri dishes. The aim research was...

Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus, present work, acetylthiophene was used as a building block to synthesize series of thiazole-bearing thiophene derivatives. The structures synthesized were elucidated based on elemental analysis spectral measurements. cytotoxic activities evaluated against MCF-7 tumor cells compared cisplatin reference drug,...

The study focuses on green methodologies in synthetic organic chemistry, emphasizing the use of thiamine hydrochloride (Vitamin B1) as an eco-friendly catalyst for synthesizing hydrazono-thiazolones. These compounds serve versatile core units with various therapeutic activities, including anti-HIV, anti-tubercular, antifungal, antiviral, and anticancer properties. Building prior research involving sustainable barium oxide-chitosan nanocomposite catalysts, this novel approach contributes to...

Recent synthesis and utilization of enamines as precursors for heterocyclic carbocyclic compounds are reviewed.Two general synthetic routes preparation based on condensation addition reactions.Enamines azaenamines can be used building blocks carbocyclic, fiveand six-membered well fused compounds.Me R O Scheme 4 DMF-DMA NMe 2 12 13A xylene 13BThe reaction methyl function in 2-butenenitriles 14 carbonitriles 15-17 with proceeds much faster is generally conducted refluxing toluene 6 h yields,...

A novel approach to the synthesis of triazolo [4,3-b][1,2,4,5]tetrazines 5a-f and [3,4b][1,3,4]thiadiazines 10a-g has been developed via reactions 4-amino-5-methyl-1,2,4-triazole-3(2H)-thione 1 with hydrazonoyl halides 2a-f 8a-g, respectively using chitosan as a basic catalyst under microwave irradiation.The structure products was established based on elemental spectral analyses.Further evidence for assigned is alternative synthesis.Also mechanism studied discussed.

Coupling of 2-cyanoacetyl-1-methyl-1H-pyrrole (1) with diazonium salts 1,4-benzenediamine (2), 2,6-dichlorobenzene-1,4-diamine (4), and benzidine (6) afforded bis-arylhydrazononitriles 3, 5, 7, respectively.Also, coupling 1 [1,2,4]triazole-3-diazonium sulfate (8) gave the respective [1,2,4] triazolo[5,2,4]triazine derivative 11.On other hands, treatment 2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-3-mercapto-3-(phenylamino)acrylonitrile (12) hydrazonoyl chlorides 13a-h in dioxane, presence chitosan...

A novel series of 1-aryl-N-[4-phenyl-5-(arylazo)thiazol-2-yl)methanimines has been synthesized via the condensation 2-amino-4-phenyl-5-arylazothiazole with various aromatic aldehydes. The imines were characterized by spectroscopic techniques, namely 1H and 13C-NMR, FTIR, MS, Elemental Analysis. molecular comparative docking study for 3a-f was calculated, reference to two approved drugs, Molnupiravir Remdesivir, using 7BQY (Mpro; PDB code 7BQY; resolution: 1.7 A°) under identical conditions....

A solution casting technique was applied to prepare a binary poly (vinyl alcohol)/Al2O3 nanocomposite. The structural properties of nanocomposite were investigated using Fourier-transform infrared spectra, field emission scanning electron microscope, energy dispersive X-ray analyses, and diffraction. hybrid PVA/Al2O3 film exhibited conspicuous catalytic performance for synthesis thiazole derivatives under mild reaction conditions. Moreover, the optimization efficiency reusability this have...

Copper oxide-chitosan nanocomposite was synthesized simply via simple solution casting method and characterized by different analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM), Thermogravimetric analysis (TGA). The copper oxide content in the prepared film estimated from Energy-dispersive (EDS) sample found to be 12.57 wt%. From XRD pattern, average particle size calculated using...

Abstract magnified image The reaction between 3‐amino‐2,3‐dihydro‐7,9‐dimethyl‐2‐thioxo‐pyrido[3′,2′:4,5]thieno[3,2‐ d ]‐pyrimidin‐4(1 H )‐one 4 or its 2‐methylthio derivative 5 with hydrazonoyl halides 6 in dioxane the presence of triethylamine under reflux has followed heterocyclization to yield pyrido[3″,2″:4′,5′]‐thieno[3′,2′:4,5]pyrimido[2,1‐ c ][1,2,4,5]tetrazin‐6(4 )‐ones 9 . On other hand, compound sodium ethoxide at room temperature led formation hydrazonothioate compounds 10 latter...