A5081648700- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Computational Drug Discovery Methods
- Liquid Crystal Research Advancements
- Synthesis and Biological Evaluation
- Conducting polymers and applications
- Click Chemistry and Applications
- biodegradable polymer synthesis and properties
- Photochromic and Fluorescence Chemistry
- Advanced Nanomaterials in Catalysis
- Nanocomposite Films for Food Packaging
- Dye analysis and toxicity
- Adsorption and biosorption for pollutant removal
- Organic Electronics and Photovoltaics
- Microwave-Assisted Synthesis and Applications
- Chemistry and Chemical Engineering
- Polymer Nanocomposite Synthesis and Irradiation
- Porphyrin and Phthalocyanine Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Nanoparticles: synthesis and applications
- solar cell performance optimization
- Ionic liquids properties and applications
- Surfactants and Colloidal Systems
- Synthesis and Properties of Aromatic Compounds
Islamic University of Madinah
2020-2025
University of Leicester
2014-2017
One crucial strategy for the treatment of breast cancer involves focusing on Vascular Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, development new inhibitors is utmost importance. In this study, novel 3-thiazolhydrazinylcoumarins were designed and synthesized via reaction phenylazoacetylcoumarin with various hydrazonoyl halides α-bromoketones. By using elemental spectral analysis data (IR, 1H-NMR, 13C-NMR, Mass), ascribed structures all newly compounds...
A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by subjection reactions carbothioamide derivative and hydrazonoyl chlorides (or α-haloketones). The cytotoxicity the compounds was evaluated against colon carcinoma cell line (HCT-116), liver (HepG2), breast (MDA-MB-231), demonstrated encouraging activity. Furthermore, when representative products assessed for toxicity normal cells, minimal toxic effects observed, indicating their potential safety use in...
Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an ecofriendly biopolymeric catalyst for synthesis of some novel thiazole thiadiazole derivatives. Thus, TCs used a promising basic biocatalyst preparation three new series thiazoles two thiadiazoles derivatives via reacting 2-(2-oxo-1,2-diphenylethylidene) hydrazine-1-carbothio-amide with various hydrazonoyl chlorides α-haloketones under mild ultrasonic irradiation. Also, their yield% estimated using in...
A novel catalytic approach for the synthesis of symmetric and asymmetric azines has been developed. The environmentally benign protocol was achieved via condensation 1-[(2-thienyl)ethylidene]hydrazine (1) with different aromatic aldehydes 2a–h acetyl heterocyclic compounds (4, 6, 8, 10, 12) in presence cellulose sulfuric acid (CSA) as green catalyst. These procedures offer an interesting method large-scale industrial manufacture due to their high percentage yield, mild reaction conditions,...
Green synthesis using L-proline as an organocatalyst is crucial due to its reusability, mild conditions, clean reactions, easy workup, high purity, short reaction times, and yields. However, existing methods often involve harsh conditions longer times. In this study, 2-cyano-N’-(2-cyanoacetyl)acetohydrazide (3) was prepared condensed with various benzaldehyde derivatives yield 2-cyano-N’-(2-cyano-3-phenylacryloyl)-3-phenylacrylohydrazide (5a–e, 7a,b) a grinding technique moist L-proline....
New homologues series of liquid crystalline materials namely, (E)-3-methoxy-4-[(p-tolylimino)methyl]phenyl 4-alkloxybenzoates (I-n), were designed and evaluated for their mesomorphic optical behavior. The prepared constitutes three members that differ from each other by the terminally attached alkoxy chain group, these vary between 6 12 carbons. A laterally OCH3 group is incorporated into central benzene ring in meta position with respect to ester moiety. Mesomorphic characterizations...
L-Proline organocatalyst was investigated as an efficient and environmentally benign catalyst for synthesis of some novel bioactive benzil bis(2-cyano-3-aryl-2-propenoylhydrazone) derivatives from reaction the bis(cyanoacetylhydrazone) with respective aldehydes. The reusability L-proline tested results revealed that recovered can be reused at least three additional times in subsequent reactions without significant decrease product yield. current protocol is very it provides mild reaction,...
A new set of laterally OCH3-substituted photoactive liquid crystalline analogues, 4-hexyloxy phenyl- imino-4ʹ-(3-methoxyphenyl)-4ʹ’-alkoxybenzoates, were synthesized and investigated for their mesomorphic behavior. The prepared constitutes five analogues that differ from each other by the terminally attached compact polar group. Characterization derivatives is conducted using differential scanning calorimetry (DSC), polarized optical microscopy (POM), UV-spectroscopy. Molecular structures...
One of the worst diseases, cancer claims millions lives each year throughout world, necessitating creation novel treatments. In this study, we designed a series 1,3,4-thiadiazoles through reaction 2-(4-methyl-2-(2-(1-phenylethylidene)hydrazineyl)thiazole-5-carbonyl)-N-phenylhydrazine-1-carbothioamide (3) with proper hydrazonoyl halides. Using MTT assay, newly synthesized thiadiazoles' growth-inhibitory potential against liver cell line HepG2-1 was assessed. comparison to standard drug...
Deep eutectic solvents are shown to be effective modifiers enable polyethylene blended with starch make a plastic which can more easily degraded.
Aminohydrazide cross-linked chitosan (CLCS) and its MWCNTs (CLCS/MWCNTs) were formulated utilized as a potent ecofriendly basic heterogeneous biocatalyst under ultrasonic irradiation for synthesis of two novel series benzil bis-aryldiazenylthiazoles bis-arylhydrazonothiazolones from the reaction bis-thiosemicarbazone with 2-oxo-N′-arylpropanehydrazonoyl chlorides ethyl 2-chloro-2-(2-phenylhydrazono) acetates, respectively. The chemical structures newly synthesized derivatives elucidated by...
Simple quaternary ammonium salts combined with glycols form effective modifiers that produce flexible thermoplastic starch which has mechanical properties comparable to some polyolefin plastics.
Owing to its broad spectrum biological activity, pyrimidines have been extensively employed as building blocks for synthesizing various drug mimic molecules. In the present work, a novel 2-hydrazineyl-5-(2-phenylhydrazineylidene)pyrimidine-4,6(1H,5H)-dione 3 was prepared and subsequently reacted with variety of substituted benzaldehyde derivatives 4a–c, 6, heteroaryl ketones namely, 2-acetylthiophene 8, acetophenone 10a, 2-acetylpyridine 10b, or 3-acetylindole 12 give respective hydrazones...
Abstract 4‐Amino‐5‐mercapto‐4 H ‐1,2,4‐triazole derivative 1 was used as a key intermediate for the preparation of 1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazepine derivatives 5a‐d , 12a‐g and 16 via reactions with appropriate chalcones 2a‐d α,β‐unsaturated carbonitrile 9a‐g 13 respectively. The identity synthesized compounds elucidated their spectral data elemental analysis. Moreover, sedative‐hypnotic activity newly were evaluated showed excellent activities especially 12b 12f . Also, structure...