Pyrazoles, thiazoles and fused have been reported to possess many biological activities. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides 3a,b (obtained from the reaction of ethyl 3-oxo-2-(2-arylhydrazono)butanoates 1a,b with thiosemicarbazide) could be transformed into a variety thiazolyl-pyrazole derivatives 6a-h, 10a-c, 15a-c, 17, 19 21 via their diversity hydrazonoyl chlorides as well bromoacetyl derivatives. Moreover, computational studies were carried out...

Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 'priority unstudied' conserved humans, providing varied...

Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 ‘priority unstudied’ conserved humans, providing varied...

Twelve bis-thiadiazole derivatives were synthesized in high yield via the reaction of 2,2′-terephthaloyl bis(N-phenylhydrazine carbothioamide) with a variety hydrazonoyl chlorides ethanol containing catalytic amounts TEA. All newly compounds characterized by physical and chemical tools (FT-IR, 1H NMR, 13C Mass spectrometry). Moreover, all novel screened for their antihypertensive α-blocking efficacy against to assess pharmaceutical significance. The encouraging promising results obtained...

Abstract 4‐Amino‐5‐mercapto‐4 H ‐1,2,4‐triazole derivative 1 was used as a key intermediate for the preparation of 1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazepine derivatives 5a‐d , 12a‐g and 16 via reactions with appropriate chalcones 2a‐d α,β‐unsaturated carbonitrile 9a‐g 13 respectively. The identity synthesized compounds elucidated their spectral data elemental analysis. Moreover, sedative‐hypnotic activity newly were evaluated showed excellent activities especially 12b 12f . Also, structure...

Method: A series of novel thiazole derivatives were synthesized in a good yield via reaction 2-(1-(4-methyl-2-phenylthiazol-5-yl)ethylidene)hydrazine carbothioamide with hydrazonoyl halides. The was performed the presence DABCO as an organocatalyst short times, easy workup, to excellent yields. structure newly products elucidated elemental analysis, spectral data and alternative routes whenever possible. Ten compounds evaluated for their anti-cancer activity against colon carcinoma cell line...

A new series derived from 4-(2-chloroacetyl)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one was synthesized, characterized and its pharmacological activity toward aromatase enzyme inhibition screened compared to the reference native ligand letrozole. The most active compound of 16, showing IC50 value 0.0023 ± 0.0002 μm letrozole with 0.0028 0.0006 μm. In addition, compounds 26 36 exhibit good activities close values 0.0033 0.0001 0.0032 0.0003 μm, respectively. Moreover, molecular...

COVID19 emerged as one of the biggest global public health crises in recent history. Many pharmaceutical companies have raced against time to develop a vaccine, so that pandemic can be brought under control. The aim current study was assess acceptance vaccine among general population Iraq. A cross-sectional conducted 1069 respondents from different states Iraq using questionnaires administered online. Though total 77.6% agreed take when available, majority (64.3%) said they would wait for...

Polycystic ovary syndrome (PCOS) is a popular illness in women after puberty age. It’s described via overdone androgen production, and ovulation unrest while elevating metabolic syndrome. PCOS was usually diagnosed by Ultrasound or blood test to check the androgens other hormone levels. There are many causes of having pathogenesis POCS which related abnormalities levels, insulin resistance, obesity, others. symptoms could include irregular periods, excess body hair, weight gain, oily skin,...

A new Schiff base, methyl (E)-(6-(((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4yl)imino)(phenyl)methyl)-1H-benzo[d]imidazol-2-yl)carbamate(L) has been synthesized from 4-aminoantipyrine and mebendazol. Metal complexes of the base were prepared metal ions MII = VO, Mn, Co, Ni, Cu, Zn, Cd Hg in alcoholic medium with mole ratio (M:L) (1:2). The have general composition [M(L)2Cl2].H2O, [(VO)(L)2(SO4)].H2O, [M(L)2(H2O)Cl].H2O, [Ni(L)2Cl].H2O. ligand all characterized by modern...

The severe acute respiratory syndrome coronavirus 2 (SARS CoV2-CoV-2) viral outbreak in Wuhan (China) caused thousands of confirmed cases and deaths around the world. Severe pneumonia with failure death are ultimate consequence infection.This study aimed to evaluate regularly performed standard laboratory parameters that can assist COVID-19 case identification establish an effective approach help care management (COVID-19) patients.COVID-19 (n = 129) patients were hospitalized Suez Canal...

A new ligand of Schiff base (L") [methyl (E)-(6-((2-isonicotinoylhydrazineylidene) (phenyl) methyl) -1H - benzo[d]imidazol-2’-yl) carbamate] (3) was prepared from the reaction isoniazid (1) and mebendazole (2) in presence HBr (48%) ethanol. The complexes were metal ions M(II)=V, Mn, Co, Ni, Cu, Cd, Zn, Hg with ethanol acetone. All compounds characterized by FT-IR, 1H NMR,13C NMR, UV.Vis, Mass spectroscopy, magnetic susceptibility measurements, atomic absorption, thermal analyses, elemental...

In this work, A proposed block cipher algorithm is designed with multiple of 32 bits as a length performed in heterogonous dependent on the application field , Multiple 48 key are entered automatically used variable permutation, addition function and xor operation. single round to giving fast high security different Purposes. Another functions for purpose such Balance Function between balance fixed number initial permutation inverse Maps lookup table (map2,map3,map4 map5). Wave nonlinear...

Clp1 is a Cdc14-family phosphatase that reverses mitotic Cdk1 phosphorylation. Despite evolutionary conservation, 's mammalian orthologs do not share this function. Rather, higher eukaryotic Cdc14 enzymes act in DNA repair, ciliogenesis, and gene regulation. To examine if regulates expression, we compared the transcriptional profiles of cells lacking function to wildtype. Because

New mixed ligand complexes were prepared from 2-Amino-4-nitrophenol (HL1) with curcumin (HL2) and some metal ions M = [ Mn (II), Co Ni Zn Cd Hg(II)], 1:1:1 Molar ratio by using ethanol as a solvent. The characterized spectroscopic measurements (UV spectrum, IR mass spectrometry, atomic absorption) along chlorine content, magnetic sensitivity, melting point, elements analysis (C.H.N), molar conductivity. octahedral geometry was proposed for all according to the results obtained. biological...

Web service technology is one of the trend technologies in computer science now, and recently with rapid growth web services deployed same functionality, many researches proposed selection systems to automatically rank select optimum between candidates. However, role these limited at selecting optimal only, they did not introduce a direct solution step over failure situations real time out changing client application. In this work, we new automated supervision system based on Multi Agents...

Composite materials are commonly used in nearly every sector of civil and military industries, the idea reinforcement is not new, this study was done with fibers nanoparticles, aim research to effect silica Kevlar fiberglass on properties composite material contained epoxy resin. And phenol-formaldehyde (95% / 5%), respectively.

In the present work, proceeding ligand as well its complexes have been studied, through studying of effects temperature that ranges from (25o to 45oC) and a variety concentrations on molar conductivity values Arinus' law application. The limiting Ligand (L) [M(L)2Cl]Cl.H2O complex in different was measured, by which decomposition constant uniform are determined, thermo-dynamic parameters (i.e. ΔH, ΔG ΔS) had estimated then discussed. Results shown value is increased with increase decreased...

This study describes the synthesis of new Schiff base ligand (L') derived from isatin with 2- amino-6-methylbenzothaizole, also prepared mixed complexes curcumin (HL) and metal ions, give formula: [M(L)(L') Cl] where: M = [Mn, Co, Ni, Cu, Zn, Cd], With (M: HL: L') [1:1:1] in ethanol as a solvent. The all were characterized by spectroscopic measurements (IR, 1H,13C-NMR, UV-Vis, A.A., LC-mas), magnetic susceptibility, elemental microanalysis, molar conductivity, chloride content, melting...

Abstract Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 ‘priority unstudied’ conserved humans, providing...

Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants all 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 ‘priority unstudied’ conserved humans, providing varied...