A5071990660- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Microbial Metabolic Engineering and Bioproduction
- Plant tissue culture and regeneration
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Biomedical Text Mining and Ontologies
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Protein Structure and Dynamics
- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
- Machine Learning in Bioinformatics
University College London
2021-2023
Institute of Structural and Molecular Biology
2023
University of Warwick
2018
Plants differ from animals in their capability to easily regenerate fertile adult individuals terminally differentiated cells. This unique developmental plasticity is commonly observed nature, where many species can reproduce asexually through the ectopic initiation of organogenic or embryogenic programs. While organ-specific epigenetic marks are not passed on during sexual reproduction, fate asexual reproduction and implications for clonal progeny remain unclear. Here we report that...
Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 'priority unstudied' conserved humans, providing varied...
Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 ‘priority unstudied’ conserved humans, providing varied...
Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark ageing. Rearrangements challenging to detect in non-dividing cell populations, because they reflect individually rare, heterogeneous events. The genomic distribution de novo cells, their dynamics during ageing, remain therefore poorly characterized. Studies instability ageing have focussed on mitochondrial DNA, small genetic...
Abstract Plants differ from animals in their capability to easily regenerate fertile adult individuals terminally differentiated cells [1]. This unique developmental plasticity is commonly observed nature where many species can reproduce asexually through the ectopic initiation of organogenic or embryogenic programs [2, 3]. However, it not currently known if this reprogramming coupled a global epigenomic resetting, what impact has on phenotype clonal progeny. Here we show that plants...
Abstract Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 ‘priority unstudied’ conserved humans, providing...
Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants all 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 ‘priority unstudied’ conserved humans, providing varied...
Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe broad cues on protein functions. assayed colony-growth phenotypes to measure the fitness of deletion mutants 3509 non-essential genes 131 conditions different nutrients, drugs, stresses. These analyses exposed 3492 mutants, including 124 ‘priority unstudied’ conserved humans, providing varied...