A5024310218- Synthesis and biological activity
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cholinesterase and Neurodegenerative Diseases
- Nanomaterials for catalytic reactions
- Toxin Mechanisms and Immunotoxins
- Curcumin's Biomedical Applications
- Synthesis and Reactions of Organic Compounds
- Global Cancer Incidence and Screening
- Nanoparticles: synthesis and applications
- Nonlinear Optical Materials Research
- Synthesis of Organic Compounds
- Molecular Sensors and Ion Detection
- Alzheimer's disease research and treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Mercury impact and mitigation studies
- Graphene and Nanomaterials Applications
- Synthesis of heterocyclic compounds
- Chemistry and Chemical Engineering
- Gas Sensing Nanomaterials and Sensors
- Crystal structures of chemical compounds
- Advanced Photocatalysis Techniques
- Click Chemistry and Applications
- Andrographolide Research and Applications
Taibah University
2019-2024
University of Technology Malaysia
2019-2021
The novel coronavirus, COVID-19, caused by SARS-CoV-2, is a global health pandemic that started in December 2019. effective drug target among coronaviruses the main protease Mpro, because of its essential role processing polyproteins are translated from viral RNA. In this study, bioactivity some selected heterocyclic drugs named Favipiravir (1), Amodiaquine (2), 2'-Fluoro-2'-deoxycytidine (3), and Ribavirin (4) was evaluated as inhibitors nucleotide analogues for COVID-19 using computational...
For the first time, calcium oxide (CaO) and oxide/carbon (CaO/C) are prepared by thermal decomposition from eggshell coffee wastes as photocatalysts. The morphological, structural, chemical optical properties of nanopowders were investigated using a variety techniques. crystallite size for plane (111) increases 564.09 Å CaO to 1654.67 CaO/C, according XRD. CaO/C photocatalyst has high increase in light absorption visible spectrum. bandgaps 1.73 1.52 eV, respectively. After 35 min sunlight...
Using a simple approach, silver nanoparticles (Ag NPs) were synthesized from green coffee bean extract. The optical color change yellowish to reddish-brown of the green-produced Ag NPs was initially observed, which confirmed by UV-Visible spectrophotometer's surface plasmonic resonance (SPR) bands at 329 and 425 nm. functional groups coffee-capped (GC-capped studied using Fourier transform infrared spectrometer, revealing that had been capped phytochemicals, resulting in excellent stability,...
One of the worst diseases, cancer claims millions lives each year throughout world, necessitating creation novel treatments. In this study, we designed a series 1,3,4-thiadiazoles through reaction 2-(4-methyl-2-(2-(1-phenylethylidene)hydrazineyl)thiazole-5-carbonyl)-N-phenylhydrazine-1-carbothioamide (3) with proper hydrazonoyl halides. Using MTT assay, newly synthesized thiadiazoles' growth-inhibitory potential against liver cell line HepG2-1 was assessed. comparison to standard drug...
Owing to its broad spectrum biological activity, pyrimidines have been extensively employed as building blocks for synthesizing various drug mimic molecules. In the present work, a novel 2-hydrazineyl-5-(2-phenylhydrazineylidene)pyrimidine-4,6(1H,5H)-dione 3 was prepared and subsequently reacted with variety of substituted benzaldehyde derivatives 4a–c, 6, heteroaryl ketones namely, 2-acetylthiophene 8, acetophenone 10a, 2-acetylpyridine 10b, or 3-acetylindole 12 give respective hydrazones...
Honey-iQfood is an herbal supplement made of a mixture polyherbal extracts and wild honey. The traditionally claimed to improve various conditions related brain cells functions including dementia Alzheimer's disease. Glycogen synthase kinase-3 beta (GSK-3β) cyclin-dependent kinase 5 (CDK5) have been identified as being involved in the pathological hyperphosphorylation tau proteins, which leads formation neurofibrillary tangles causes Therefore, this study was conducted confirm traditional...
An efficient microwave-assisted one-step synthetic route toward Mannich bases is developed from 4-hydroxyacetophenone and different secondary amines in quantitative yields, via a regioselective substitution reaction. The reaction takes short time non-catalyzed reproducible on gram scale. environmentally benign methodology provides novel alternative, to the conventional methodologies, for synthesis of mono- disubstituted 4-hydroxyacetophenone. All compounds were well-characterized by FT-IR,...
(2021). Synthesis, molecular docking and biochemical analysis of aminoalkylated naphthalene-based chalcones as acetylcholinesterase inhibitors. Journal Taibah University for Science: Vol. 15, No. 1, pp. 781-797.
Andrographis paniculata is a herbal plant that has been used traditionally for decades to treat wide range of diseases. To this date, no research on the integration in silico, vitro, and vivo pharmacokinetics (PK) documented andrographolide (AG), primary bioactive compound A. paniculata. In study, we employed an silico approach predict physicochemical properties, metabolism, toxicity AG. PK properties were validated using vitro assays further tested Wistar rats. Based prediction, AG...
Abstract C 14 H 10 O 2 , triclinic, P 1̄ (no. 2), a = 7.498(3) Å, b 7.973(3) c 9.660(4) α 67.211(13)°, β 84.489(14)°, γ 72.224(14)°, V 506.8(4) Å 3 Z 2, R gt (F ) 0.0394, wR ref ( F 0.1135, T 100(2) K.
Background: In the world, one among most popular widely widespread medical illnesses is thyroid-disorder.People may suffer due to poor knowledge they have about symptoms and risk-factors.This article intends evaluate general population's awareness of thyroiddisorders in KSA.Methodology: A cross-sectional online survey with different sections based on 'yes', 'no' 'I don't know' questions was conducted amongst Saudi Arabia's public, using a pre-designed questionnaire.Statistical Packages for...