A5086427429- Atherosclerosis and Cardiovascular Diseases
- Mast cells and histamine
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Muscle Physiology and Disorders
- Cholesterol and Lipid Metabolism
- Endometrial and Cervical Cancer Treatments
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Aortic Thrombus and Embolism
- Pluripotent Stem Cells Research
- Inflammasome and immune disorders
- Psoriasis: Treatment and Pathogenesis
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Cervical Cancer and HPV Research
- Neurogenesis and neuroplasticity mechanisms
Charles River Laboratories (Netherlands)
2023
Brigham and Women's Hospital
2020-2022
Harvard University
2022
Centre for Human Drug Research
2015-2019
Leiden University
2014-2019
University of Patras
2011
Inflammasomes are multiprotein complexes, and their activation has been associated with cardiovascular disease. Inflammasome leads to secretion of caspase-1 by innate immune cells, resulting in the interleukin-1β. Recently, a potent selective inhibitor NLRP3 inflammasome, MCC950, was described. In this study, we investigated effect MCC950 on atherosclerotic lesion development apoE-/- mice.First, determined efficacy vitro. Bone marrow-derived macrophages dendritic cells were stimulated...
The role of interleukin (IL)-17 in cancer remains controversial. In view the growing interest targeting IL-17, knowing its cellular sources and clinical implications is crucial. present study, we unraveled phenotype IL-17 expressing cells cervical using immunohistochemical double immunofluorescent triple stainings. tumor stroma, was found to be predominantly expressed by neutrophils (66%), mast (23%), innate lymphoid (8%). Remarkably, T-helper 17 (Th17) were a minor population (4%). A...
T lymphocytes play an important role in atherosclerosis development, but the of CD8+ T-cell remains debated, especially clinically relevant advanced stages development. Here, we set out to determine T-cells atherosclerosis.Human endarterectomy samples analysed by flow cytometry showed a negative correlation between percentage and macrophages, suggesting possible protective for these cells lesion To further test this hypothesis, LDLr-/- mice were fed western-type diet (WTD) 10 weeks induce...
The immune checkpoint receptor lymphocyte-activation gene 3 (LAG3) is a new target for blockade (ICB), but the effects of LAG3 on atherosclerosis are not known.
During cortical development, coordination of proliferation and differentiation ensures the timely generation different neural progenitor lineages that will give rise to mature neurons glia. Geminin is an inhibitor DNA replication it has been proposed regulate cell fate determination during neurogenesis via interactions with transcription factors chromatin remodeling complexes. To investigate in vivo role maintenance progenitors, we have generated mice lack expression developing cortex. Our...
The presence of mast cells in human atherosclerotic plaques has been associated with adverse cardiovascular events. Mast cell activation, through the classical antigen sensitized-IgE binding to their characteristic Fcε-receptor, causes release cytoplasmic granules. These granules are filled neutral proteases such as tryptase, but also histamine and pro-inflammatory mediators. accumulate high numbers within tissue, particularly shoulder region plaque. findings largely based on...
Abstract Lysophosphatidic acid (LPA) is a natural lysophospholipid present at high concentrations within lipid-rich atherosclerotic plaques. Upon local accumulation in the damaged vessels, LPA can act as potent activator for various types of immune cells through its specific membrane receptors 1/3. elicits chemotactic, pro-inflammatory and apoptotic effects that lead to plaque progression. In this study we aimed inhibit signaling by means 1/3 antagonism using small molecule Ki16425. We show...
Mast cells (MCs) are potent innate immune that aggravate atherosclerosis through the release of proinflammatory mediators inside atherosclerotic plaques. Similarly, CD4+ T constituents adaptive response and accumulate within plaques following lipid-specific activation by APCs. Recently it has been proposed these two cell types can interact in a direct manner. However, no indication such an interaction investigated context atherosclerosis. In our study, we aimed to examine whether MCs act as...
Huntington's disease (HD) is caused by an expanded CAG trinucleotide repeat in exon 1 of the huntingtin (HTT) gene. We report design a series HTT pre-mRNA splicing modulators that lower protein, including toxic mutant (mHTT), promoting insertion pseudoexon containing premature termination codon at 49-50 junction. The resulting transcript undergoes nonsense-mediated decay, leading to reduction mRNA transcripts and protein levels. starting benzamide core was modified pyrazine amide further...
Meeting abstracts Cervical cancer is the second leading cause of death in young women worldwide. The aim current study was to identify which combination immunological and vascular factors tumor microenvironment cervical carcinoma most significant for survival. Using
Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) describes somatic mutations bone marrow derived blood cells in the absence overt hematological disease. CHIP correlates with aging and atherosclerotic cardiovascular diseases humans. Tet2 mutations, common CHIP, augment atherosclerosis. -deficient macrophages over-express Interleukin-(IL)1β mRNA response to LDL. IL-1β neutralization reduces recurrent events patients post myocardial infarction residual inflammatory risk.We...