A5024702194- Atherosclerosis and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protease and Inhibitor Mechanisms
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Aortic Thrombus and Embolism
- Renal Transplantation Outcomes and Treatments
Dartmouth–Hitchcock Medical Center
2025
Brigham and Women's Hospital
2018-2024
Harvard University
2018-2019
Neutrophils likely contribute to the thrombotic complications of human atheromata. In particular, neutrophil extracellular traps (NETs) could exacerbate local inflammation and amplify propagate arterial intimal injury thrombosis. PAD4 (peptidyl arginine deiminase 4) participates in NET formation, but an understanding this enzyme's role atherothrombosis remains scant.This study tested hypothesis that NETs influence experimental atherogenesis processes implicated superficial erosion, a form...
Abstract Aims Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post-myocardial infarction with residual inflammatory risk. Yet, some mouse data have shown prominent role IL-1α rather than atherosclerosis, or even deleterious effect IL-1 on outward arterial remodelling atherosclerosis-susceptible mice. To shed light these disparate results, this study investigated neutralizing or/and...
Background: Clonal hematopoiesis of indeterminate potential (CHIP) refers to somatic mutations in hematopoietic cells with a minimum allele fraction ≥ 2% without hematological disease. CHIP depends on age and increases the risk coronary artery disease (CAD). In their 70s women’s prevalence cardiovascular catches up that men. Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) neutralizing interleukin-1β (IL-1β) chronic CAD, subjects TET2 showed greater reduction events. However,...
Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) describes somatic mutations bone marrow derived blood cells in the absence overt hematological disease. CHIP correlates with aging and atherosclerotic cardiovascular diseases humans. Tet2 mutations, common CHIP, augment atherosclerosis. -deficient macrophages over-express Interleukin-(IL)1β mRNA response to LDL. IL-1β neutralization reduces recurrent events patients post myocardial infarction residual inflammatory risk.We...