A5076433018- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Plant Pathogens and Fungal Diseases
- COVID-19 Clinical Research Studies
- Advanced Chemical Sensor Technologies
- Cytomegalovirus and herpesvirus research
- Antimicrobial Peptides and Activities
- Metabolomics and Mass Spectrometry Studies
- Immune responses and vaccinations
- Yeasts and Rust Fungi Studies
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Nail Diseases and Treatments
- CRISPR and Genetic Engineering
- T-cell and Retrovirus Studies
- interferon and immune responses
- COVID-19 and Mental Health
- Receptor Mechanisms and Signaling
The University of Texas Southwestern Medical Center
2023-2024
Northern Arizona University
2019-2023
Texas Center for Infectious Disease
2017-2018
The University of Texas at San Antonio
2017-2018
Development of vaccines against opportunistic infections is difficult as patients most at risk developing disease are deficient in aspects the adaptive immune system. Here, we utilized an experimental immunization strategy to induce innate memory macrophages vivo. Unlike current trained immunity models, present memory-like phenotype that maintained for least 70 days post-immunization and results complete protection secondary challenge absence cells. RNA-seq analysis vivo IFN-γ primed...
Coccidioides immitis and C. posadasii are soil dwelling dimorphic fungi found in North South America. Inhalation of aerosolized asexual conidia can result asymptomatic, acute, or chronic respiratory infection. In the U.S. there approximately 350,000 new infections per year. The genus is only known fungal pathogen to make specialized parasitic spherules, which contain endospores that released into host upon spherule rupture. molecular determinants involved this key step infection remain...
Abstract Coccidioidomycosis (“Valley fever”) is caused by Coccidioides immitis and C. posadasii . These fungi are thermally dimorphic, cycling between mycelia arthroconidia in the environment converting into spherules endospores within a host. can cause broad spectrum of disease that be difficult to treat. There has been steady increase disease, with an estimated 350,000 new infections per year United States. With difficulty treatment, there unmet need research basic biology identify...
Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly C. neoformans (serotypes A and D) gattii B C). To date, there no clinically available vaccine to prevent cryptococcosis. Mice given an experimental pulmonary vaccination with serotype strain engineered produce IFN-γ, denoted H99γ, are protected against subsequent otherwise lethal infection A. Thus, we determined the efficacy of immunization H99γ elicit broad-spectrum protection in BALB/c mice disparate...
Coccidioides immitis and posadasii are soil-dwelling fungi of arid regions in North South America that responsible for Valley fever (coccidioidomycosis). Forty percent patients with exhibit symptoms ranging from mild, self-limiting respiratory infections to severe, life-threatening pneumonia requires treatment. Misdiagnosis as bacterial commonly occurs symptomatic cases, resulting inappropriate treatment antibiotics, increased medical costs, delay diagnosis. In this proof-of-concept study,...
The rapid evolution of SARS-CoV-2 variants highlights the need for new therapies to prevent disease spread. SARS-CoV-2, like SARS-CoV-1, uses human cell surface protein angiotensin-converting enzyme 2 (ACE2) as its native receptor. Here, we design and characterize a mutant ACE2 that enables affinity purification dimeric by altering active site autoproteolytic digestion C-terminal His
Abstract The rapid evolution of SARS-CoV-2 variants highlights the need for new therapies to prevent disease spread. SARS-CoV-2, like SARS-CoV-1, uses human cell surface protein angiotensin-converting enzyme 2 (ACE2) as its native receptor. Here, we design and characterize a mutant ACE2 that enables affinity purification dimeric by altering active site autoproteolytic digestion C-terminal His 10 epitope tag. In cultured cells, competitively inhibits lentiviral vectors pseudotyped with spike...
Abstract Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, is the causative agent of disease 2019, COVID-19, and current COVID-19 pandemic. Even as more vaccine candidates are released, treatment options critically needed. Here, we investigated use Minnelide, a water soluble pro-drug with anti-inflammatory properties, for COVID-19. To do this, k18-hACE2 mice were infected SARS-CoV-2 or given PBS control intranasally. The next day either treated daily low dose (0.0025mg/day) high...
ABSTRACT Coccidioides immitis and posadasii are soil-dwelling fungi of arid regions in North South America that responsible for Valley fever (coccidioidomycosis). Forty percent patients with exhibit symptoms ranging from mild, self-limiting respiratory infections, to severe, life-threatening pneumonia requires treatment. Misdiagnosis as bacterial commonly occurs symptomatic cases, resulting inappropriate treatment antibiotics, increased medical costs, delay diagnosis. In this study, we...