A5082366990- Malaria Research and Control
- Mosquito-borne diseases and control
- Curcumin's Biomedical Applications
- Viral Infections and Vectors
- Travel-related health issues
- Marine Sponges and Natural Products
- Computational Drug Discovery Methods
- Bone health and treatments
- Research on Leishmaniasis Studies
- Click Chemistry and Applications
- Toxoplasma gondii Research Studies
- Invertebrate Immune Response Mechanisms
- RNA and protein synthesis mechanisms
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Synthesis and biological activity
- Drug-Induced Hepatotoxicity and Protection
- Synthesis and Characterization of Heterocyclic Compounds
- Trypanosoma species research and implications
University of Washington
2016-2024
Goa Medical College
2019-2024
Monash University
2013
Indian Institute of Technology Bombay
2013
IITB-Monash Research Academy
2013
Curcumin has been widely investigated for its myriad cellular effects resulting in reduced proliferation of various eukaryotic cells including cancer and the human malaria parasite Plasmodium falciparum. Studies with cell lines HT-29, Caco-2, MCF-7 suggest that curcumin can bind to tubulin induce alterations microtubule structure. Based on this finding, we whether any effect P. falciparum microtubules, considering mammalian are 83% identical. IC50 was found be 5 µM as compared 20 reported...
Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out Africa Southeast Asia to characterize examine determinants Plasmodium falciparum vivax malaria pathogenesis, fewer conducted India.A prospective study malaria-positive individuals was at Goa Medical College Hospital (GMC) from 2012 2015 identify demographic, diagnostic clinical indicators associated with P. infection on univariate analysis.Between 2015, 74,571...
The South Asia International Center of Excellence for Malaria Research, an NIH-funded collaborative program, investigated the epidemiology malaria in Indian state Goa through health facility-based data collected from Medical College and Hospital (GMC), state's largest tertiary healthcare facility, between 2012 2021. Our study region-specific spatial temporal patterns transmission factors driving such patterns. Over past decade, number cases, inpatients, deaths at GMC decreased significantly...
Artemisinin-based combination therapy (ACT) has been used to treat uncomplicated Plasmodium falciparum infections in India since 2004. Since 2008, a decrease artemisinin effectiveness seen throughout the Greater Mekong Subregion. The geographic proximity and ecological similarities of northeastern Southeast Asia may differentially affect long-term management sustainability ACT India.
ABSTRACT Due to the spread of resistance front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), secondary metabolite symbiotic bacterium marine bivalve mollusks, promising antimalarial because it inhibits growth sexual and asexual blood stages Plasmodium falciparum at sub-nanomolar levels. The potency TrtE warrants further investigation into its mechanism action, cytotoxicity, ease with which parasites may evolve it.
The genetic diversity within the circumsporozoite surface protein (PvCSP) of Plasmodium vivax, predominant malaria species in Thailand, is primarily observed northwestern region along Thailand–Myanmar border. However, as P. vivax cases shift to southern provinces, particularly Yala Province near Thailand–Malaysia border, PvCSP remains understudied. Between 2018 and 2020, 89 isolates were collected Province, a significant hotspot. Employing polymerase chain reaction amplification, restriction...
Background: Lead compounds that target tubulin are being developed as agents against the human malaria parasite, Plasmodium falciparum. It is important to define binding sites of these molecules on dimer: Taxol, Vinca domains or novel pockets; however, extraction native parasite difficult. Objective: This report aims develop assays allow rapid assessment dimer. Method: We have a simple growth assay, using combination two anti-microtubule drugs overlapping sites, study whether act in...
ABSTRACT. The Malaria Evolution in South Asia (MESA) International Center for Excellence Research (ICEMR) was established by the US National Institutes of Health (US NIH) as one 10 malaria research centers endemic countries. In years hospital-based and field-based work India, MESA-ICEMR has documented changing epidemiology transmission four different parts India. Asia-ICEMR activities, collaboration with Indian partners, are carried out broad thematic areas case surveillance, vector biology...
ABSTRACT. The Malaria Evolution in South Asia (MESA) International Center of Excellence for Research (ICEMR) conducted research studies at multiple sites India to record blood-slide positivity over time, but also study broader aspects the disease. From Southwest (Goa) Northeast (Assam), MESA-ICEMR invested equipment, operational capacity, and trained personnel observe frequencies Plasmodium falciparum vivax infections, clinical presentations, treatment effectiveness, vector transmission,...