A5051972045- Malaria Research and Control
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Digital Imaging for Blood Diseases
- Child Nutrition and Water Access
- COVID-19 epidemiological studies
- Adolescent Sexual and Reproductive Health
- Syphilis Diagnosis and Treatment
- Vector-borne infectious diseases
- HIV/AIDS drug development and treatment
- Biosensors and Analytical Detection
- Viral Infections and Vectors
- Vibrio bacteria research studies
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Hemoglobinopathies and Related Disorders
- Zoonotic diseases and public health
- vaccines and immunoinformatics approaches
- Tuberculosis Research and Epidemiology
- Trypanosoma species research and implications
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Diverse Scientific Research Studies
National Institute of Malaria Research
2015-2025
Academy of Scientific and Innovative Research
2024-2025
Indian Council of Medical Research
2007-2024
National Institute of Health and Family Welfare
2023
Ministry of Health and Family Welfare
2023
National Dairy Research Institute
2023
National Institute for Research in Tribal Health
2007-2009
Malaria elimination will be possible only with serious attempts to address asymptomatic infection and chronic by both Plasmodium falciparum vivax. Currently available drugs that can completely clear a human of P. vivax (known as "radical cure"), reduce transmission malaria parasites, are those in the 8-aminoquinoline drug family, such primaquine. Unfortunately, people glucose-6-phosphate dehydrogenase (G6PD) deficiency risk having severe adverse reactions if exposed these at certain doses....
Introduction This highly contagious zoonotic corona virus (SARS-CoV-2) spread to most parts of the world (200 countries) and created a public health emergency. Due its novel nature indistinctness, different sources information suggestions were developed guide individuals about transmission prevent infection. Responses active intervention efforts have posed some relevant questions on population understanding attitudes toward COVID-19. The present study is aims assess COVID-19 related...
Abstract Background Despite the progress made in this decade towards malaria elimination, it remains a significant public health concern India and many other countries South Asia Pacific region. Understanding historical trends of incidence relation to various commodity policy interventions identifying factors associated with its occurrence can inform future intervention strategies for elimination goals. Methods This study analysed cases from 1990 2022 assess annual impact key anti-malarial...
The pediatric population, especially under-five children, is highly susceptible to malaria and accounts for 76 % of global deaths according the World Malaria Report 2022. purpose this manuscript discuss various factors involved in susceptibility population importance age group elimination.
Abstract Background India is committed to malaria elimination by the year 2030. According classification of endemicity, National Capital Territory Delhi falls under category 1, with an annual parasite incidence <1, and was targeted for 2022. Among others, population movement across states one key challenges control, as it can result in imported malaria, thus introducing local transmission area nearing elimination. Objective This descriptive study attempts assess contribution such...
Abstract Background Rapid diagnostic tests (RDTs) are vital for malaria diagnosis, especially in resource-limited areas. RDTs targeting histidine-rich protein 2 (PfHRP2) and its structural homologue PfHRP3 commonly used detecting Plasmodium falciparum. However, genetic deletions these proteins can affect test accuracy. This study aims to examine the gene sequence variation Pfhrp2 Pfhrp3 genes P. falciparum isolates from Chhattisgarh, India, assess their correlation with RDT reactivity....
India’s National Malaria Elimination Program, which achieved notable success in reducing cases, is now facing challenges because of the rise malaria cases 2023 and 2024. This increase linked to multiple factors, including disruptions healthcare priorities during coronavirus disease 2019 pandemic, drug insecticide resistance, under-detection asymptomatic carriers pfhrp2 -deleted parasites. The ultimate goal achieve sustainable reductions incidence transmission, paving way for a malaria-free...
Background. Artemisinin-based combination therapy is the first-line treatment for uncomplicated falciparum malaria. This study assessed antimalarial efficacy and safety of a 150 mg arterolane maleate 750 piperaquine phosphate (AM-PQP) in comparison to Coartem (artemether lumefantrine) patients with acute P. Methods. In this open-label, randomized, multicentric, parallel group clinical trial, 240 were randomized receive AM-PQP (160 patients) or (80 patients). Patients monoinfection initial...
To determine household factors associated with treatment seeking for malaria.The study was carried out in four districts of Madhya Pradesh different malaria endemicity. A total 1470 households were interviewed which at least one member suffered from microscopically confirmed the 3 months preceding survey. Socio-demographic, economic, cultural characteristics, their health beliefs, knowledge and practices regarding choice explored.A 764 high-endemic 706 low-endemic areas. More than half heads...
Abstract Dihydrofolate reductase (DHFR) is a ubiquitous enzyme that regulates the biosynthesis of tetrahydrofolate among various species Plasmodium parasite. It validated target antifolate drug pyrimethamine (Pyr) in falciparum ( Pf ), but its clinical efficacy has been hampered due to emergence resistance. This made attempt screen Food & Drug Administration‐approved drugs against wild‐ and mutant DHFR by employing an in‐silico pipeline identify potent candidates. The current study...
India contributed approximately 66% of the malaria cases in WHO South-East Asia region 2022. In India, 44% have been reported to be disproportionately by 27 districts. 1 A comparative analysis between January 2017 and December 2022 was performed Mandla district, which is site a model elimination demonstration project (MEDP) Madhya Pradesh (MP), India. Compared 2017, decrease from 2018 higher than MP rest country. The reduction significant 2018, 2019, 2021 ( p &lt; 0.01) (Mandla vs. MP)...
Abstract Chloroquine (CQ) resistance in Plasmodium falciparum is determined by the mutations chloroquine transporter ( Pfcrt ) gene. The point mutation at codon 76 (K76T), which has been observed more than 91% of P. isolates India, major determinant CQ resistance. To overcome limitations and challenges traditional methods, this investigation we developed an easy to use loop mediated isothermal amplification (LAMP) protocol for rapid detection K76T associated with naked eye visualization. In-...
We describe the epidemiological characteristics and associated risk factors of those presenting at a large testing centre for SARS-CoV-2 infection. This is retrospective record review individuals who underwent by reverse transcription-polymerase chain reaction (RT-PCR) high-throughput national-level government facility located in north India. Samples collected from 6 April to 31 December 2020 are included this work represent four highly populous regions. Additionally, there was prospective...
Plasmodium vivax is the most widely distributed human malaria parasite and accounts for approximately same number of cases as falciparum in India. Compared with P. falciparum, difficult to eradicate because its tendency cause relapses, which impacts treatment control strategies. The genetic diversity these parasites, particularly merozoite surface protein-3 alpha (msp-3α) gene, can be used help develop a potential vaccine. present study aimed investigate using highly polymorphic antigen gene...
Background & objectives: The in vitro assays for susceptibility of Plasmodium falciparum to antimalarial drugs are important tools monitoring drug resistance. During the present study, efforts were made establish long-term continuous culture Indian field isolates P. and determine their sensitivity standard antibiotics. Methods: Four (MZR-I, -II, -III -IV) obtained from four patients who showed artemisinin-based combination therapy (ACT) Mizoram, a north-eastern State India, characterized...
Sulphadoxine and pyrimethamine (SP) have been used as long-acting partner antimalarial drugs in artemisinin combination therapy (ACT) for falciparum malaria. The emergence increasing spread of SP resistance malaria-endemic areas become a challenge the control Therefore, regular monitoring mutation status is important better management drug policy. There are limitations with traditional molecular methods there an urgent need easy method diagnosis resistance. In this study we introduced...
HIGHLIGHTS Omicron and Delta have been found to be most dominant among all variants of SARS-CoV-2. SARS-CoV-2 cause various comorbidities. JAK/STAT3, MAPK1, mTOR PI3K pathways deregulated due infection caused by different
Although cercarial dermatitis is an emerging disease world-wide, cases of such may often go undiagnosed, especially in communities that are affected by various skin infections. Between August 2001 and July 2002, 1336 individuals from tribal villages central India were examined for dermatitis. Skin scrapings collected Sarcoptes scabiei each subject's response to antiscabies treatment was recorded. Freshwater snails the local ponds used bathing, cercariae. The recorded prevalence ranged...
Introduction: The diagnostic techniques for malaria are undergoing a change depending on the availability of newer diagnostics and annual parasite index infection in particular area. At country level, guidelines available selection tests; however, at local this decision is made based situation tests evaluated against gold standard, if that standard has limitations, it becomes difficult to compare other tests. Bayesian latent class analysis computes its internal rather than using conventional...
Malaria poses a major public health challenge in the Asia Pacific. Elimination Demonstration Project was conducted as public-private partnership initiative Mandla between State government, ICMR, and FDEC India. The project employed controls for efficient operational management decisions. IEC campaigns found crucial schools communities. Capacity building of local workers emphasized better diagnosis treatment. SOCH mobile app launched complete digitalization. Better supervision Indoor Residual...
ABSTRACT. Malaria elimination is one of the top health care priorities in India, necessitating accessible and accurate diagnosis for effective treatment. A malaria slide bank India a collection quality-controlled malaria-positive -negative slides considered vital asset quality diagnosis. The blood samples, preparation smears, staining, control, molecular characterizations, validation were carried out according to standard operating procedures accordance with WHO reference laboratory. true...