A5101574564- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Advanced Breast Cancer Therapies
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Myeloid Leukemia Treatments
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Colorectal Cancer Treatments and Studies
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Medicinal Plants and Neuroprotection
- Lung Cancer Treatments and Mutations
- Myasthenia Gravis and Thymoma
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- COVID-19 Clinical Research Studies
UConn Health
2023
Indraprastha Apollo Hospitals
2022
Cellworks Research (India)
2013-2018
King George's Medical University
2018
Dementia with Lewy bodies is the second most common neurodegenerative form of dementia following Alzheimer’s disease, affecting 0.4% people over age 65 every year. It more commonly diagnosed in men than women, and typically 50. a synucleinopathy, which alpha-synuclein inclusions accumulate neurons, similar to idiopathic Parkinson’s disease multiple system atrophy. Clinical features include cognitive decline, bradykinetic movements, visual hallucinations. Neuroimaging reveals occipital...
Following penetrating injury of the skin, a highly orchestrated and overlapping sequence events helps to facilitate wound resolution. Inflammation is hallmark that initiated early, but reciprocal relationship between cells matrix molecules triggers maintains inflammation poorly appreciated. Elastin enriched in deep dermis skin. We propose tissue encompasses elastin damage, yielding solubilized inflammation. As dermal fibroblasts dominate dermis, this means direct interaction sequences would...
Even with numerous studies the cause of Parkinson's disease (PD) remains elusive. It has been hypothesized that interactions between genetic and environmental factors may play an important role in pathogenesis PD.To examine gene-gene gene-environment interaction on PD risk respect to gene polymorphism cytochrome P450 2D6 (CYP2D6) glutathione S-transferases pi 1 (GSTP1), organochlorine pesticides (OCPs) metals.This study included 70 patients 100 age-matched controls. The restriction fragment...
Mucormycosis is almost always confined to the patients with altered host defenses amongst which diabetes considered as strongest risk factor. COVID-19 only been seen in severe cases but also mild and moderate of SARS-CoV-2 infections. After preliminary clinical radiological diagnosis, surgical management form endoscopic sinus surgery, debridement, orbital exenteration (8) was performed. Medical antifungal therapy (amphotericin-B, posaconazole, isavuconazole) initiated. In this case series,...
HIGHLIGHTS Omicron and Delta have been found to be most dominant among all variants of SARS-CoV-2. SARS-CoV-2 cause various comorbidities. JAK/STAT3, MAPK1, mTOR PI3K pathways deregulated due infection caused by different
// Sukhmani K. Padda 1 , Yesim Gökmen-Polar 2 Jessica A. Hellyer Sunil S. Badve Neeraj Singh 3 Sumanth M. Vasista Kabya Basu Ansu Kumar and Heather Wakelee Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA, USA Indiana Medicine, Indianapolis, IN, Cellworks Group, San Jose, Correspondence to: Padda, email: sukhmani.padda@cshs.org Keywords: thymic epithelial tumor; thymoma; genomics; clustering; computational analysis Received: April 02, 2021 Accepted: May 15,...
Abstract Background: The unique signature of a patient's tumor mandates the need to rationally design personalized therapies employing N=1 segmentation conceptually. By focusing on designed treatments, our strategy targets key pathways address clinical problem therapy resistance. To overcome bortezomib resistance, we have (1) employed predictive simulation modeling using patient genomic profiling specific combinatorial therapeutic regimens and (2) validated ex-vivo in patient-derived cell...
Abstract Ruxolitinib/Jakafi is a current front line therapy for JAK2-mediated myelofibrosis. Like other chemotherapy agents, prolonged use of the drug confers resistance. However, mechanisms that allow development Ruxolitinib resistance are poorly understood. Moreover, there paucity alternative treatment options these resistant patients. To address timely issues, we first took BaF3/JAK2-V617F cells and selected variant. After selection through increasing concentrations Ruxolitinib, grow...
e23169 Background: Most cancers follow a polygenic mode of progression to ensure their survival; not defined by single aberration but through multiple abnormalities acting in concert. Existing molecular profiling techniques are unable account for this; thus, the clinical benefit derived has been marginal. Advances parallel computing and machine learning algorithms may overcome limitations current tools. Here, we report on novel predictive technology capable constructing digital avatar, based...
Owing to the increasing life expectancy, prevalence of age-dependent neurodegenerative diseases will exert an enormous toll on our aging population, their caregivers and healthcare system. It is anticipated that numbers patients suffering from such as Alzheimer’s disease (AD), Parkinson’s (PD), other are poised increase markedly over next few decades. Therefore, discovering treatments mitigate deleterious effects these imperative. The common feature loss neurons, due accumulation abnormal...
Abstract Hypomethylating agents (HMA) and lenalidomide (LEN) are approved used in the treatment of patients (pts) with MDS, though these drugs fail most pts. No method exists to predict drug response beyond associating single actionable mutations a drug's response. We hypothesized that MDS pts can be clustered by similarities genomic/molecular profiles, & each cluster may assigned combos FDA-approved target their unique biomarker profile. Bone marrow cells from 88 MDS-L cell line were...