A5083742888- Chemokine receptors and signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Mosquito-borne diseases and control
- Immune cells in cancer
- Extracellular vesicles in disease
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Effects of Radiation Exposure
- Bone Metabolism and Diseases
- Radiation Therapy and Dosimetry
- Circular RNAs in diseases
- Viral Infections and Outbreaks Research
- RNA Interference and Gene Delivery
- Protein Tyrosine Phosphatases
- Vibrio bacteria research studies
- interferon and immune responses
- Bacillus and Francisella bacterial research
- Veterinary medicine and infectious diseases
UConn Health
2019-2023
Cleveland Clinic
2019
Uniformed Services University of the Health Sciences
2012-2017
Jackson Foundation
2017
Henry M. Jackson Foundation
2017
Birla Institute of Technology and Science, Pilani
2012-2016
Neuroinflammation is a hallmark of several neurodegenerative diseases and disorders, including traumatic brain injury (TBI). results in the activation glial cells which exacerbates neuroinflammatory process by secretion pro-inflammatory cytokines disruption transmission networks. The cells, astrocytes, play critical role maintenance homeostasis brain. Activated astrocytes release factors as part inflammatory cytokines, proteins, microRNAs (miRNAs). MiRNAs are noncoding RNA molecules involved...
Neurofibrillary tangles likely cause neurodegeneration in Alzheimer's disease (AD). We demonstrate that the CX3CL1 C-terminal domain can upregulate neurogenesis, which may ameliorate neurodegeneration. Here we generated transgenic (Tg-CX3CL1) mice by overexpressing neurons. Tg-CX3CL1 exhibit enhanced neurogenesis both subgranular and subventricular zones. This correlates well with elevated expression of TGF-β2 TGF-β3, activation their downstream signaling molecule Smad2. Intriguingly, adult...
The membrane-anchored CX3CL1 is best known to exert its signaling function through binding receptor CX3CR1. This study demonstrates a novel that exerts. sequentially cleaved by α-, β-, and γ-secretase, the released intracellular domain (CX3CL1-ICD) would translocate into cell nucleus alter gene expression due this back-signaling function. Amyloid deposition neuronal loss were significantly reduced when C-terminal fragment (CX3CL1-ct) was overexpressed in Alzheimer’s 5xFAD mouse model....
The radioprotective capacity of a rationally-designed Mn2+-decapeptide complex (MDP), based on Mn antioxidants in the bacterium Deinococcus radiodurans, was investigated mouse model radiation injury. MDP previously reported to be extraordinarily proteins setting vaccine development. peptide-component (DEHGTAVMLK) applied here selected from group synthetic peptides screened vitro for their ability protect cultured human cells and purified enzymes extreme damage caused by ionizing (IR). We...
Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries Americas, making it emerging pathogen of great global health importance. Venezuelan equine encephalitis (VEEV), a New alphavirus, on other hand, been developed as bioweapon past due to its ease preparation, aerosol dispersion high lethality aerosolized form. Currently, there are no FDA approved vaccines against these viruses. In this study, we used novel...
CX3CL1, also known as fractalkine, is best for its signaling activity through interactions with cognate receptor CX3CR1. However, intrinsic function that independent of interaction CX3CR1 remains to be fully understood. We demonstrate the intracellular domain CX3CL1 (CX3CL1-ICD), generated upon sequential cleavages by α-/β-secretase and γ-secretase, initiates a back activity, which mediates direct signal transmission gene expression in nucleus. To study this, we fused synthetic peptide...
Owing to the increasing life expectancy, prevalence of age-dependent neurodegenerative diseases will exert an enormous toll on our aging population, their caregivers and healthcare system. It is anticipated that numbers patients suffering from such as Alzheimer’s disease (AD), Parkinson’s (PD), other are poised increase markedly over next few decades. Therefore, discovering treatments mitigate deleterious effects these imperative. The common feature loss neurons, due accumulation abnormal...