A5050237671- Malaria Research and Control
- Mosquito-borne diseases and control
- RNA and protein synthesis mechanisms
- COVID-19 epidemiological studies
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
- Enzyme Structure and Function
- Biochemical and Molecular Research
- Trypanosoma species research and implications
- HIV Research and Treatment
- Complement system in diseases
- Global Maternal and Child Health
- Drug-Induced Hepatotoxicity and Protection
- Viral Infections and Vectors
- HIV/AIDS drug development and treatment
- Antimicrobial Peptides and Activities
- COVID-19 Clinical Research Studies
- Protein Structure and Dynamics
- vaccines and immunoinformatics approaches
- Travel-related health issues
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Vector-borne infectious diseases
- Computational Drug Discovery Methods
International Centre for Genetic Engineering and Biotechnology
2016-2025
Centro de Ingeniería Genética y Biotecnología
2014-2025
Immunocore (United Kingdom)
2025
National Institute of Malaria Research
2010-2024
Virginia Commonwealth University
2020-2024
Indo Soviet Friendship College of Pharmacy
2023-2024
Jagannath University
2023-2024
All India Institute of Medical Sciences
2016-2024
Swami Rama Himalayan University
2024
Institute of Medical Sciences
2024
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, actively remodels transcriptome its hosting cells with profound and coupled impact on host immune response. We report secretes GRA24, novel dense granule protein which traffics from vacuole to cell nucleus. Once released into cell, GRA24 has unique ability trigger prolonged autophosphorylation nuclear translocation p38α MAP...
To assess national and regional trends causes-specific distribution of maternal mortality in India.Nationally representative cross-sectional surveys.All India from 1997 to 2020.About 10 000 deaths among 4.3 million live births over two decades.We analysed the ratio (MMR) through 2020, estimated absolute examined causes death using nationally data sources. We partitioned female (aged 15-49 years) birth totals, based on 2001-2014 Million Death Study United Nations (UN) demographic totals for...
Glioblastoma multiforme is a lethal cancer that responds poorly to therapy. cancer-initiating cells have been shown mediate resistance both chemotherapy and radiation; however, it unknown what extent these contribute the profound immunosuppression in glioblastoma patients if strategies alter their differentiation state can reduce this immunosuppression.We isolated subpopulation of from possessed capacity for self-renewal, formed neurospheres vitro, were capable pluripotent differentiation,...
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment malaria in particular, are high priority; however, there few chemically validated targets. The natural product cladosporin is active against blood- liver-stage Plasmodium falciparum Cryptosporidium parvum cell-culture studies. Target deconvolution P. has shown that inhibits lysyl-tRNA synthetase ( Pf KRS1). Here, we report identification a series...
Calcium-dependent protein kinases (CDPKs) play important roles in the life cycle of Plasmodium falciparum and other apicomplexan parasites. CDPKs commonly have an N-terminal kinase domain (KD) a C-terminal calmodulin-like (CamLD) with calcium-binding EF hands. The KD CamLD are separated by junction (JD). Previous studies on Toxoplasma suggest role for JD regulation activity. Here, we provide direct evidence binding P3 region (Leu356 to Thr370) presence calcium (Ca2+). Moreover, site-directed...
Bicyclic azetidines potently inhibit Cryptosporidium in vivo by targeting phenylalanyl-tRNA synthetase.
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from single B cells of the COVID-19–recovered individuals in India who experienced ancestral Wuhan strain (WA.1) SARS-CoV-2 during early stages pandemic, we found a receptor binding domain (RBD)–specific mAb 002-S21F2 that has rare gene usage and potently neutralized live viral isolates variants including Alpha, Beta, Gamma, Delta, Omicron sublineages (BA.1, BA.2, BA.2.12.1, BA.4, BA.5) with IC 50 ranging...
Surge of SARS CoV-2 infections ascribed to omicron variant began in December 2021 New Delhi. We determined the infection and reinfection density a cohort health care workers (HCWs) along with vaccine effectiveness (VE) against symptomatic within transmission period (considered from 01, February 25, 2022.This is an observational study All India Institute Medical Sciences, Data were collected telephonically. Person-time at risk was counted November 30, till date infection/ reinfection, or...
Plasmodium parasites are causative agents of malaria which affects >500 million people and claims approximately 2 lives annually. The completion genome sequencing availability PlasmoDB database has provided a platform for systematic study parasite genome. Aminoacyl-tRNA synthetases (aaRSs) pivotal enzymes protein translation other vital cellular processes. We report an extensive analysis the falciparum to identify classify aaRSs in this organism.Using various computational bioinformatics...