A5102994302- HIV Research and Treatment
- Chronic Disease Management Strategies
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Heart Failure Treatment and Management
- Immune Cell Function and Interaction
- Diabetes Management and Education
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Function and Risk Factors
- Patient Satisfaction in Healthcare
- SARS-CoV-2 detection and testing
- Health Systems, Economic Evaluations, Quality of Life
- Air Quality and Health Impacts
- Hip and Femur Fractures
- Effects and risks of endocrine disrupting chemicals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Grief, Bereavement, and Mental Health
- Frailty in Older Adults
- Organizational Leadership and Management Strategies
- Central Venous Catheters and Hemodialysis
- Global Health Care Issues
Guru Nanak Dev University
2024
National Skin Centre
2024
National University Health System
2024
National University of Singapore
2021-2024
University of Delhi
2023
National Centre for Infectious Diseases
2013-2021
SingHealth
2018-2021
Hasselt University
2021
University of Antwerp
2021
Tan Tock Seng Hospital
2010-2017
Background. Artemisinin-based combination therapy is the first-line treatment for uncomplicated falciparum malaria. This study assessed antimalarial efficacy and safety of a 150 mg arterolane maleate 750 piperaquine phosphate (AM-PQP) in comparison to Coartem (artemether lumefantrine) patients with acute P. Methods. In this open-label, randomized, multicentric, parallel group clinical trial, 240 were randomized receive AM-PQP (160 patients) or (80 patients). Patients monoinfection initial...
Patients with nonmalignant end-stage organ diseases often incur healthcare costs in the last year of life that are disproportionately higher than period prior. Studies on expenditure (HCE) trends these patients have largely focused final life, and examining a longer-term trajectory could better support professionals to target timing methods care management. In this study, we aim describe HCE trajectories disease (ESOD) over 5 years compared against advanced cancer (AC). We conducted...
Recent studies suggest HIV-1 inter-subtype differences in co-receptor usage. We examined the correlation between subtype and usage among treatment-naïve subjects Singapore. Additionally, we investigated whether association was influenced by stage of infection. V3 sequences envelope protein gp120 were obtained from 110 HIV patients genotypic tropism determination performed using Geno2pheno. Two false-positive rate (FPR) cut-offs, 10% 5.75% selected for testing. Subtype assignment viral...
This study aims to quantify medical care utilisation, and describe the cost trajectories of individuals with advanced illnesses in last-year life, differentiated by cancer, end-stage organ failure progressive neurological disorders.This retrospective database included decedents who had previous inpatient or outpatient encounters at a public hospital Singapore. Patients diseases were identified based on diagnostic codes clinical criteria. Using look-back approach, amount healthcare services...
Introduction Measuring health activation in general population using valid instruments is needed to facilitate the evaluation of education and behavioral programs community. The 13-item Patient Activation Measure was well validated patients with different chronic diseases but rarely population. objective this study assess psychometric properties among community-dwelling adults Singapore. Methods Data participants having responses English-version measure (N = 824) were analyzed. assessed by...
Abstract Background Challenges in prognosticating patients diagnosed with advanced dementia (AD) hinders timely referrals to palliative care. We aim develop and validate a prognostic model predict one-year all-cause mortality (ACM) AD presenting at an acute care hospital. Methods This retrospective cohort study utilised administrative clinical data from Tan Tock Seng Hospital (TTSH). Patients admitted TTSH between 1st July 2016 31st October 2017 identified have were included. The primary...
Objectives HIV-1 viral quantitation is essential for treatment monitoring. An in-house assay would decrease financial barriers to access. Materials and Methods A real-time competitive RT-PCR in house (Sing-IH) was developed Singapore. Using HXB2 as reference, the assay's primers probes were designed generate a 183-bp product that overlaps portion of LTR region gag region. internal control (IC) included each monitor false negative results due inhibition or human error. Clinical evaluation...
Abstract Background Hearing aids (HA) is the primary medical intervention aimed to reduce hearing handicap. This study assessed cost-effectiveness of HA for older adults who were volunteered be screened loss in a community-based mobile clinic (MHC). Methods Participants with (1) at least moderate (≥40 dB HL) one ear, (2) no prior usage HA, (3) ear related complications, and (4) had Mini-Mental State Examination score ≥ 18 eligible this study. Using delayed-start design, participants...
emergency department interventions for frailty (EDIFY) delivers frailty-centric at the (ED). We evaluated effectiveness of a multicomponent intervention (MFI) in improving functional outcomes among older persons.a quasi-experimental study.a 30-bed ED observation unit within 1,700-bed acute tertiary hospital.patients aged ≥65 years, categorised as Clinical Frailty Scale 4-6, and planned discharge from unit.we compared patients receiving MFI versus usual-care. Data on demographics, function,...
Abstract We estimated the generation interval distribution for coronavirus disease on basis of serial intervals observed infector–infectee pairs from established clusters in Singapore. The short mean and consequent high prevalence presymptomatic transmission requires public health control measures to be responsive these characteristics epidemic.
Abstract The genotoxic activity of diesel exhaust emissions, particulate matter, and an organic extract the matter was evaluated in transplacentally exposed Syrian hamster fetal liver cells. frequency sister chromatid exchange (SCE) determined on day 13 gestation. caused a dose‐dependent increase SCE with doubling incidence above 320mg/kg. emissions did not alter SCE. cause decrease mitotic liver. utero analysis demonstrated to be sensitive assay for determination complex mixture fetuses.
Objective Multimorbidity in patients with heart failure (HF) results poor prognosis and is an increasing public health concern. We aim to examine the effect of multimorbidity focusing on type 2 diabetes mellitus (T2DM) chronic kidney disease (CKD) all-cause cardiovascular (CVD)-specific mortality among diagnosed HF Singapore. Design Retrospective cohort study. Setting Primary tertiary care three (out six) Regional Health Systems Participants Patients between 2003 2016 from restructured...
Objectives: High body mass index (BMI) has been associated with increased mortality, healthcare utilization and costs. This study investigates the one-year chronic disease progression risk of developing diabetes varying cardiovascular (CVD) risks based on Asian BMI categories. Methods: Patients information from 2008 to 2014 were included in analysis ( N=23,508). stratified into low, moderate, high very CVD To for patients risks, further segmented seven mutually exclusive states prevalence...
Human immunodeficiency virus type 1 (HIV-1) genotyping resistance test (GRT) is essential for monitoring HIV-1 drug mutations (DRMs). High cost and genetic variability are challenges to assay availability in Singapore. An in-house Sanger sequencing-based GRT method was developed at the Communicable Disease Centre (CDC), Singapore's HIV national treatment reference centre both subtype B non-subtype HIV-1.The sequenced fi rst 99 codons of protease (PR) 244 reverse transcriptase (RT) pol gene....
Patients with chronic lung diseases (CLDs), defined as progressive and life-limiting respiratory conditions, experience a heavy symptom burden the conditions become more advanced, but palliative referral rates are low late. Prognostic tools can help clinicians identify CLD patients at high risk of deterioration for needs assessments to care. As current prognostic may not generalize well across all we aim develop validate general model predict one-year mortality in presenting any CLD.
The current study provides a comprehensive quantitative analysis of the impact Global Value Chains (GVCs) on global presence, financial health, and competitiveness Chinese banks from 2000 to 2023. Econometric models are employed quantify how China’s integration into GVCs has shaped its banking sector, with particular focus expansion performance stage. Objectives include assessing influence GVC participation internationalization strategies banks, examining relationship between GVC-related...